Declínio da memória episódica relacionado à idade e o papel da beta-amiloide: uma revisão sistemática

Souto, Jandirlly Julianna; Silva, Gabriella Medeiros; Almeida, Natalia Leandro; Shoshina, Irina Ivanovna; Santos, Natanael Antonio; Fernandes, Thiago Paiva

doi:10.1590/1980-57642021dn15-030002

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Brasil

Dementia & Neuropsychologia

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Brasil

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Sumário

Original Article • Dement. neuropsychol. 15 (03) • Jul-Sep 2021 • https://doi.org/10.1590/1980-57642021dn15-030002 copiar

Declínio da memória episódica relacionado à idade e o papel da beta-amiloide: uma revisão sistemática

Autoria SCIMAGO INSTITUTIONS RANKINGS

RESUMO

O envelhecimento tem sido associado a um declínio funcional da memória episódica (ME). Algo ainda sem resposta é se o declínio da ME ocorre mesmo no envelhecimento saudável e se esse declínio pode estar relacionado à deposição de Aβ no hipocampo.

Objetivo:

Nosso objetivo principal foi investigar os dados sobre a relação entre a memória episódica e a deposição de Aβ no envelhecimento saudável.

Métodos:

Nós buscamos nas bases de dados Cochrane, MEDLINE, Scopus, Web of Science e nas listas de referências dos estudos dos últimos 10 anos. A busca inicial nas bases de dados identificou 517 estudos. Após a triagem de título, resumos, palavras-chave e referências, 56 estudos atenderam aos critérios de inclusão.

Resultados:

O resultado geral revelou que o aumento de Aβ estava relacionado ao menor volume do hipocampo e pior desempenho em testes de ME. Em resumo, os resultados da presente revisão sistemática revelaram que altos níveis de Aβ podem estar relacionados ao declínio de ME e conversão progressiva para a Doença de Alzheimer.

Conclusões:

Aqui, discutimos os pontos fortes e as limitações dos testes e técnicas para investigar a deposição ME e Aβ, bem como questões metodológicas e direções futuras.

Palavra-chave:
memória; memória episódica; envelhecimento; envelhecimento saudável; peptídeos beta-amiloides; revisão sistemática

Authors	Sample	Aβ technique	Others techniques	Regions of interest	EM task	Main findings	PEDro	AXIS
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Rahayel et al.¹⁰³103. Rahayel S, Bocti C, Sévigny Dupont P, Joannette M, Lavallée MM, Nikelski J, et al. Subcortical amyloid relates to cortical morphology in cognitively normal individuals. Eur J Nucl Med Mol Imaging. 2019;46(11):2358-69. https://doi.org/10.1007/s00259-019-04446-w https://doi.org/https://doi.org/10.1007/...	104	PiB-PET	MRI	–	WMS - III and RAVLT	Higher Aβ had worse episodic memory	5	17
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6-TSRT: 6-Trial Selective Reminding Test; Aβ: amyloid-β; AD: Alzheimer’s disease; ADAS-Cog: Alzheimer’s Disease Assessment Scale–Cognitive Subscale; APOE: apolipoprotein E; AVF: Animal Verbal Fluency Test; AVLT: Auditory Verbal Learning Test; BDNF: brain-derived neurotrophic factor; BNT: Boston Naming Test; BVRT: Benton Visual Retention Test; CAA: cerebral amyloid angiopathy; CANTAB: Cambridge Neuropsychological Test Automated Battery; CSF: cerebrospinal fluid; COBT: Cogstate One Back Task; COCLT: Cogstate One Card Learning task; CVLT-II: California Verbal Learning Test, second edition; DMST: Delayed Matching-to-Sample Task; DTI: diffusion tensor imaging; EEG: electroencephalogram; ELISA: enzyme-linked immunosorbent assay; EM: episodic memory; FCSRT: Free and Cued Selective Reminding Test; FDG: fluorodeoxyglucose; FLAIR: fluid attenuation inversion recovery; fMRI: functional magnetic resonance imaging; FNAME: Face–Name Associative Memory Exam; FNET: Face–Name Experimental Task; FSRT: Free and Selective Reminding Test; HVLIR: Hopkins Verbal Learning Immediate Recall; HVLT: Hopkins Verbal Leaning Task; PiB-PET: Pittsburgh compound B positron emission tomography; IA: immunosorbent assay; LMT-II: Logical Memory Test, second edition; LMR: Logical Memory Recall; LMIR: Logical Memory Immediate Recall and Delayed Recall; MAC-Q: Memory Complaint Questionnaire; MAS: Memory Assessment Scale; MBT: Memory Binding Test; MMSE: Mini Mental State Examination; MPRAGE: magnetization-prepared rapid gradient echo; MRI: magnetic resonance imaging; MCT: Memory Capacity Test; mPFC: medial prefrontal cortex; MR: magnetic resonance; MTL: medial temporal lobe; N/A: no data available; OCL: One Card Learning; PAL: paired-associate learning; P-tau: tau pathology; RAVLT: Rey Auditory Verbal Learning Test; RCFT: Rey Complex Figure Test; ROCF: Rey-Osterrieth complex figure; RPM: Raven’s Progressive Matrices; SCC: subjective cognitive concerns; SCPT: Short Cognitive Performance Test; SENAS: Spanish and English Neuropsychological Assessment Scale; SMD: subjective memory decline; SRM: selected reaction monitoring; SRT: Selective Reminding Test; STSRT: Six-Trial Selective Reminding Test; SUVR: neocortical standardized uptake value ratio; TMADA: TaqMan allelic discrimination assay; TWPT: the word-pairs task; VPATS: Visual Paired Associates Total Score; VL: vascular load; VRM: verbal recognition memory; VRT: Visual Reproduction test; VWLT: Verbal Word Learning Test; WAIS: Wechsler Adult Intelligence Scale; WLM-V: Wechsler Logical Memory–Delayed Recall; WM: working memory; WMS-RLM: Wechsler Memory Scale-Revised Logical Memory; WMS-RVR II: Wechsler Memory Scale-Revised Visual Reproductions II; WLIRD: Word List Immediate Recall and Delayed Recall; WLM-I: Wechsler Logical Memory I and II Story A Immediate; WMH: white matter hyperintensities.

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E-mail: revistadementia@abneuro.org.br | demneuropsy@uol.com.br

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[1] Thiago Paiva Fernandes. Cidade Universitária, S/N – Castelo Branco – 58051-900 João Pessoa PB – Brazil. E-mail: thiagompfernandes@gmail.com