Age-related episodic memory decline and the role of amyloid-β: a systematic review

Souto, Jandirlly Julianna; Silva, Gabriella Medeiros; Almeida, Natalia Leandro; Shoshina, Irina Ivanovna; Santos, Natanael Antonio; Fernandes, Thiago Paiva

doi:10.1590/1980-57642021dn15-030002

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Brasil

Dementia & Neuropsychologia

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Brasil

Español English

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Original Article • Dement. neuropsychol. 15 (03) • Jul-Sep 2021 • https://doi.org/10.1590/1980-57642021dn15-030002 copy

Age-related episodic memory decline and the role of amyloid-β: a systematic review

Declínio da memória episódica relacionado à idade e o papel da beta-amiloide: uma revisão sistemática

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Aging has been associated with the functional decline of episodic memory (EM). Unanswered questions are whether the decline of EM occurs even during healthy aging and whether this decline is related to amyloid-β (Aβ) deposition in the hippocampus.

Objective:

The main purpose of this study was to investigate data on the relationship between the age-related EM decline and Aβ deposition.

Methods:

We searched the Cochrane, MEDLINE, Scopus, and Web of Science databases and reference lists of retrieved articles that were published in the past 10 years. The initial literature search identified 517 studies. After screening the title, abstract, key words, and reference lists, 56 studies met the inclusion criteria.

Results:

The overall results revealed that increases in Aβ are related to lower hippocampal volume and worse performance on EM tests. The results of this systematic review revealed that high levels of Aβ may be related to EM deficits and the progression to Alzheimer’s disease.

Conclusions:

We discussed the strengths and pitfalls of various tests and techniques used for investigating EM and Aβ deposition, methodological issues, and potential directions for future research.

Keywords:
memory; episodic; aging; healthy aging; beta amyloid; systematic review

Authors	Sample	Aβ technique	Others techniques	Regions of interest	EM task	Main findings	PEDro	AXIS
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Rahayel et al.¹⁰³103. Rahayel S, Bocti C, Sévigny Dupont P, Joannette M, Lavallée MM, Nikelski J, et al. Subcortical amyloid relates to cortical morphology in cognitively normal individuals. Eur J Nucl Med Mol Imaging. 2019;46(11):2358-69. https://doi.org/10.1007/s00259-019-04446-w https://doi.org/https://doi.org/10.1007/...	104	PiB-PET	MRI	–	WMS - III and RAVLT	Higher Aβ had worse episodic memory	5	17
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6-TSRT: 6-Trial Selective Reminding Test; Aβ: amyloid-β; AD: Alzheimer’s disease; ADAS-Cog: Alzheimer’s Disease Assessment Scale–Cognitive Subscale; APOE: apolipoprotein E; AVF: Animal Verbal Fluency Test; AVLT: Auditory Verbal Learning Test; BDNF: brain-derived neurotrophic factor; BNT: Boston Naming Test; BVRT: Benton Visual Retention Test; CAA: cerebral amyloid angiopathy; CANTAB: Cambridge Neuropsychological Test Automated Battery; CSF: cerebrospinal fluid; COBT: Cogstate One Back Task; COCLT: Cogstate One Card Learning task; CVLT-II: California Verbal Learning Test, second edition; DMST: Delayed Matching-to-Sample Task; DTI: diffusion tensor imaging; EEG: electroencephalogram; ELISA: enzyme-linked immunosorbent assay; EM: episodic memory; FCSRT: Free and Cued Selective Reminding Test; FDG: fluorodeoxyglucose; FLAIR: fluid attenuation inversion recovery; fMRI: functional magnetic resonance imaging; FNAME: Face–Name Associative Memory Exam; FNET: Face–Name Experimental Task; FSRT: Free and Selective Reminding Test; HVLIR: Hopkins Verbal Learning Immediate Recall; HVLT: Hopkins Verbal Leaning Task; PiB-PET: Pittsburgh compound B positron emission tomography; IA: immunosorbent assay; LMT-II: Logical Memory Test, second edition; LMR: Logical Memory Recall; LMIR: Logical Memory Immediate Recall and Delayed Recall; MAC-Q: Memory Complaint Questionnaire; MAS: Memory Assessment Scale; MBT: Memory Binding Test; MMSE: Mini Mental State Examination; MPRAGE: magnetization-prepared rapid gradient echo; MRI: magnetic resonance imaging; MCT: Memory Capacity Test; mPFC: medial prefrontal cortex; MR: magnetic resonance; MTL: medial temporal lobe; N/A: no data available; OCL: One Card Learning; PAL: paired-associate learning; P-tau: tau pathology; RAVLT: Rey Auditory Verbal Learning Test; RCFT: Rey Complex Figure Test; ROCF: Rey-Osterrieth complex figure; RPM: Raven’s Progressive Matrices; SCC: subjective cognitive concerns; SCPT: Short Cognitive Performance Test; SENAS: Spanish and English Neuropsychological Assessment Scale; SMD: subjective memory decline; SRM: selected reaction monitoring; SRT: Selective Reminding Test; STSRT: Six-Trial Selective Reminding Test; SUVR: neocortical standardized uptake value ratio; TMADA: TaqMan allelic discrimination assay; TWPT: the word-pairs task; VPATS: Visual Paired Associates Total Score; VL: vascular load; VRM: verbal recognition memory; VRT: Visual Reproduction test; VWLT: Verbal Word Learning Test; WAIS: Wechsler Adult Intelligence Scale; WLM-V: Wechsler Logical Memory–Delayed Recall; WM: working memory; WMS-RLM: Wechsler Memory Scale-Revised Logical Memory; WMS-RVR II: Wechsler Memory Scale-Revised Visual Reproductions II; WLIRD: Word List Immediate Recall and Delayed Recall; WLM-I: Wechsler Logical Memory I and II Story A Immediate; WMH: white matter hyperintensities.

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E-mail: revistadementia@abneuro.org.br | demneuropsy@uol.com.br

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[1] Thiago Paiva Fernandes. Cidade Universitária, S/N – Castelo Branco – 58051-900 João Pessoa PB – Brazil. E-mail: thiagompfernandes@gmail.com