Arsênico em nervos periféricos normais do homem

Anghinah, Abrão; Jorge, Francisco B. de; Forti, Francisco; Ferrari, Antonio F.

doi:10.1590/S0004-282X1973000400008

Resumo

As a contribution to the knowledge on inorganic arsenic concentration in peripheral nerves, a study was carried out in 20 nerve fragments (10 from N. ulnaris and 10 from N. tibialis) excised during necropsy from 20 corpses less than 24 hours after death and showing no apparent disease of the nervous system. The samples were ashed in an oven overnight at 550°C. The ashes were dissolved in a known volume of 2N-HC1. In this solution inorganic arsenic was determined by the Kingsley-Schaffert method. The results revealed no significant concentrations (vestiges) of inorganic arsenic in the peripheral nerves.

Arsênico em nervos periféricos normais do homem

Inorganic arsenic in normal human peripheral nerves

Abrão Anghinah^I; Francisco B. de Jorge^II; Francisco Forti^III; Antonio F. Ferrari^III

^IClínica Neurológica (Prof. H. M. Canelas) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo: Assistente

^IIClínica Neurológica (Prof. H. M. Canelas) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo: Chefe de Laboratório da Fac. Med. Mogi das Cruzes

^IIIClínica Neurológica (Prof. H. M. Canelas) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo: Residente

SUMMARY

As a contribution to the knowledge on inorganic arsenic concentration in peripheral nerves, a study was carried out in 20 nerve fragments (10 from N. ulnaris and 10 from N. tibialis) excised during necropsy from 20 corpses less than 24 hours after death and showing no apparent disease of the nervous system. The samples were ashed in an oven overnight at 550°C. The ashes were dissolved in a known volume of 2N-HC1. In this solution inorganic arsenic was determined by the Kingsley-Schaffert method. The results revealed no significant concentrations (vestiges) of inorganic arsenic in the peripheral nerves.

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Clínica Neurológica Hospital das Clínicas Faculdade de Medicina Caixa Postal 3461 01000 São Paulo. SP Brasil.

Nota dos autores Os autores agradecem ao Dr. Arnaldo Siqueira, Diretor do Instituto Médico-Legal de São Paulo, a permissão para retirada de fragmentos de nervos durante a necropsia dos casos incluídos neste estudo.

1. ALEXANDRE, L. & MYERSON, A. Minerals in normal and in pathologic brain tissue, studied by micro-incineration and spectroscopy. Arch. Neurol. Psychiat. (Chicago) 39:131, 1938.
2. ECKER, A. D. & KERNOHAN, S. W. Arsenic as a possible cause of subacute encephalomyelitis. Arch. Neurol. Psychiat. (Chicago) 45:24, 1945.
3. KINGSLEY, G. R. & SCHAFFERT, R. R. Microdetermination of arsenic and its application to biological material. Anal. Chem. 23:914, 1951.
4. LOWENTHAL, A. The metals of the human system. In Tedeschi, C. G. Neuropathology, Methods and Diagnosis. Little-Brown, Boston, 1970, pp. 769-778.
5. McILWAIN, H. Biochemistry and Central Nervous System. Churchill, London, ed. 3, 1966, p. 28.

Datas de Publicação

Publicação nesta coleção
15 Abr 2013
Data do Fascículo
Dez 1973

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. ALEXANDRE, L. & MYERSON, A. Minerals in normal and in pathologic brain tissue, studied by micro-incineration and spectroscopy. Arch. Neurol. Psychiat. (Chicago) 39:131, 1938.

[2] 2. ECKER, A. D. & KERNOHAN, S. W. Arsenic as a possible cause of subacute encephalomyelitis. Arch. Neurol. Psychiat. (Chicago) 45:24, 1945.

[3] 3. KINGSLEY, G. R. & SCHAFFERT, R. R. Microdetermination of arsenic and its application to biological material. Anal. Chem. 23:914, 1951.

[4] 4. LOWENTHAL, A. The metals of the human system. In Tedeschi, C. G. Neuropathology, Methods and Diagnosis. Little-Brown, Boston, 1970, pp. 769-778.

[5] 5. McILWAIN, H. Biochemistry and Central Nervous System. Churchill, London, ed. 3, 1966, p. 28.