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An invisible villain: high perceived stress, its associated factors, and possible consequences in a population-based survey in southern Brazil

Abstract

Introduction

Much of the evidence on the relationship between stress, lifestyle, and other physical and mental health outcomes comes from studies conducted in high-income countries. There is therefore a need for research among populations in low and middle-income settings.

Objectives

To measure stress levels and identify factors associated with a high stress level and its consequences for health.

Methods

This was a population-based cross-sectional study carried out in 2016 with adults aged 18 years or older in a municipality in southern Brazil. A two-stage sampling strategy based on census tracts was used. Stress levels were measured with the Perceived Stress Scale (PSS-14) and classified into quartiles. The impact of the highest stress levelon each outcome was assessed with etiologic fractions (EF).

Results

The most stressed groups were: females (PR = 1.51, 95%CI 1.25-1.81), younger people (PR = 1.76, 95%CI 1.26-2.46), middle-aged individuals (PR = 1.60, 95%CI 1.17-2.19), those with lower schooling (PR = 1.56, 95%CI 1.20-2.02), the physically inactive (PR = 1.51, 95%CI 1.20-1.91), people who spent three or more hours watching television per day (PR = 1.29, 95%CI 1.12-1.50), and those with food insecurity (PR = 1.44, 95%CI 1.19-175). Possible consequences of high stress level were regular or poor self-perception of health (EF = 29.6%), poor or very poor sleep quality (EF = 17.3%), lower quality of life (EF = 45.6%), sadness (EF = 24.2%), and depressive symptoms (EF = 35.8%).

Conclusions

Stress plays an important role in several domains of health. Both public policies that target reduction of inequalities and specific stress-management interventions can reduce stress levels in populations, thereby decreasing the burden of other negative physical and mental health outcomes related to stress.

Perceived stress; risk factors; consequences; etiologic fraction; epidemiology

Introduction

Stress can be defined as the body’s response pattern to external demands, regardless of the nature of the causative agent, and the implications of stress are of considerable interest in health research.11. Goldstein DS, Kopin IJ. Evolution of concepts of stress. Stress. 2007;10:109-20. While responses to acute stress are adaptive, chronic stress can predispose individuals to a lower quality of life and increased health problems.22. McEwen BS. Neurobiological and systemic effects of chronic stress. Chronic Stress. 2017;1:1-11. Evidence indicates that stress can hinder development of a healthy lifestyle. People under stress are more likely to adopt harmful health behaviors, such as physical inactivity, smoking, and drinking alcoholic beverages.33. Heikkilä K, Fransson EI, Nyberg ST, Zins M, Westerlund H, Westerholm P, et al. Job strain and health-related lifestyle: findings from an individual-participant meta-analysis of 118 000 working adults. Am J Public Health. 2013;103:2090-7. Stress seems to have a complex and bidirectional relationship with mental disorders, especially depression.44. Liu RT, Alloy LB. Stress generation in depression: a systematic review of the empirical literature and recommendations for future study. Clin Psychol Rev. 2010;30:582-93.

Much of the available evidence on the relationship between stress, lifestyle, and other physical and mental health outcomes comes from studies conducted in high-income countries.55. Gasperin D, Netuveli G, Dias-da-Costa JS, Pattussi MP. Effect of psychological stress on blood pressure increase: A meta-analysis of cohort studies. Cad Saude Publica. 2009;25:715-26.

6. Keller A, Litzelman K, Wisk LE, Maddox T, Cheng ER, Creswell PD, et al. Does the perception that stress affects health matter? The association with health and mortality. Heal Psychol. 2012;31:677-84.
- 77. Richardson S, Shaffer JA, Falzon L, Krupka D, Davidson KW, Edmondson D. Meta-analysis of perceived stress and its association with incident coronary heart disease. Am J Cardiol. 2012;110:1711-6. There is therefore a need for research among populations in low and middle-income settings. There are also complex interrelations between individual (gender, education, occupation, income, behaviors) and contextual factors (structure, culture, and values of the region or country in which one lives) that predispose a person to be more stressed. Failure to account for these mechanisms may lead to incomplete interpretations of possible adverse outcomes resulting from stress.

High levels of perceived stress have been associated with poorer overall physical and mental health, in addition to increased risk of premature death.66. Keller A, Litzelman K, Wisk LE, Maddox T, Cheng ER, Creswell PD, et al. Does the perception that stress affects health matter? The association with health and mortality. Heal Psychol. 2012;31:677-84. Investigating the association between psychological stress and health-related outcomes is of foremost relevance. Mapping how stress can be shaped according to individuals’ characteristics and to modifiable lifestyle behaviors, as well as its effects, can provide health professionals and key stakeholders with helpful insights and information for development of better health plans, policies, and practices.

Therefore, the objective of the present study was to identify the social, economic, demographic, and behavioral factors that are associated with perceived stress and to investigate the possible consequences of stress for the physical and mental health of the population of a municipality in southern Brazil.

Materials and methods

Study design

This cross-sectional study is part of a population-based study, titled “Health of the Population of Rio Grande” (Saúde da População Rio-Grandina]. The aim of this research was to evaluate the health of adults and the elderly in the city of Rio Grande in southern Brazil.

The project was approved by the Research Ethics Committee at the Universidade Federal do Rio Grande (protocol 20/2016; CAAE: 52939016.0.0000.5324).

Sampling plan

The sample size estimate was calculated by considering the different outcomes evaluated in the research project. The parameters considered were as follows: significance level of 5%, power of 80%, prevalence of outcome of 10%, frequency of exposure between 20 and 60%, and prevalence ratio of 2.0. Then, 50% was added to the sample size estimate to account for the sampling design effect (because sampling units were households, resulting in a cluster effect by which members of the same household tend to have more similar characteristics and responses), 15% was added to account for possible confounders, and 10% was added to account for attrition and refusals. The final sample size consisted of 1,423 individuals.

The sampling process was conducted in two stages based on the 2010 Demographic Census Data.88. Instituto Brasileiro De Geografia E Estatística (IBGE). Censo Brasileiro de 2010 [Internet]. 2012 [cited 2021 Dec 7]. censo2010.ibge.gov.br/
censo2010.ibge.gov.br/...
First, 70 of the 293 census tracts in the municipality (approximately 25%) were systematically selected. Considering that it was expected that there would be an average of two individuals aged 18 years or over per household,88. Instituto Brasileiro De Geografia E Estatística (IBGE). Censo Brasileiro de 2010 [Internet]. 2012 [cited 2021 Dec 7]. censo2010.ibge.gov.br/
censo2010.ibge.gov.br/...
711 households (1,423 ÷ 2) were selected, with a probability proportional to the size of the census tract. All individuals aged 18 years or older in each of the households selected were invited to take part in the study.

Procedures

First, the study was publicized via interviews on local radio stations, publications in local newspapers, and television newscasts, and on a social media page on the internet. Second, preliminary visits were made to selected households by study supervisors, in order to verify household characteristics (whether it was a residential address and to determine number of residents eligible for the study), to inform residents about the study, and to schedule interviews. Data collection was conducted between April and July 2016 using a precoded and standardized questionnaire that had been tested previously and was administered by trained interviewers. People who agreed to participate signed a consent form. Data on sex and age were collected from those who did not agree to participate. Data were input twice by different supervisors using EpiData 3.1 software. More details regarding the sample size calculation, sampling plan, and fieldwork logistics can be found elsewhere.99. Dumith SC, Paulitsch RG, Carpena MX, Muraro MF, Simões MO, Machado KP, et al. Planning and execution of a population health survey by means of a multidisciplinary research consortium. Sci Med (Porto Alegre). 2018;28:1-8.

Variables and instruments

The outcome was perceived stress, measured using the Perceived Stress Scale,1010. Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983;24:385-96. which is a 14-item instrument that assesses the frequency with which an individual has experienced certain feelings and situations. This scale has been translated and validated for use in the Brazilian setting.1111. Di Bernardi Luft C, de Oliveira Sanches S, Mazo GZ, Andrade A. Brazilian version of the Perceived Stress Scale: translation and validation for the elderly. Rev Saude Publica. 2007;41:606-15. A Likert scale was used, with response options ranging from 0 (never) to 4 (always) points. A total score ranging from 0 to 56 points is generated by summing the scores for all questions. The variable perceived stress was operationalized in quartiles based on the total score. The top quartile was considered the group with the highest stress levels (the most stressed individuals).

Independent variables included in the analyses were sex, age, skin color, marital status, living alone, schooling level, wealth index (generated through a principal component analysis with 11 items of home assets or house characteristics and then categorized into tertiles), smoking, excessive alcohol consumption (five or more drinks for men and four or more drinks for women on a single occasion in the previous 30 days1212. Wechsle H, Nelson T. Binge drinking and the American college student: what’s five drinks? Psychol Addict Behav. 2001;15:287-91. ), physical activity during leisure time (some or none), hours per day watching television, food insecurity (defined as any score above zero on the Brazilian Scale of Food Insecurity1313. Segall-Corrêa AM, Marin-León L, Melgar-Quiñonez H, Pérez-Escamilla R. Refinement of the Brazilian household food insecurity measurement scale: recommendation for a 14-item EBIA. Rev Nutr. 2014;27:241-51. ), and whether the respondent had visited a physician in the previous month.

The possible physical and psychological consequences of stress evaluated herein were back pain in the previous 12 months (self-reported, no/yes), obesity (self-reported body mass index ≥ 30 kg/m22. McEwen BS. Neurobiological and systemic effects of chronic stress. Chronic Stress. 2017;1:1-11. ), self-perception of health (excellent, very good or good/regular or poor), quality of sleep (very good, good or regular/poor or very poor), quality of life as measured by the World Health Organization instrument validated in Brazil (total score operationalized into quintiles),1414. Fleck MP, Louzada S, Xavier M, Chachamovich E, Vieira G, Santos L, et al. Application of the Portuguese version of the abbreviated instrument of quality life WHOQOL-bref. Rev Saude Publica. 2000;34:178-83. sadness as measured by the Andrews and Whitney face scale (defined as those who reported feeling unhappy or very unhappy),1515. McDowell I. Measuring Health: a guide to rating scales and questionnaires. Oxford: Oxford University Press; 2009. depressive symptoms (absent/present) as measured by the Patient Health Questionnaire (PHQ-9) validated in the Brazilian population,1616. Santos IS, Tavares BF, Munhoz TN, de Almeida LS, da Silva NT, Tams BD, et al. [Sensitivity and specificity of the Patient Health Questionnaire-9 (PHQ-9) among adults from the general population]. Cad Saude Publica. 2013;29:1533-43. and self-reported medical diagnosis of hypertension, diabetes or cardiopathy (no/yes). It is worth noting that the term “possible consequences” refers to outcomes that are theoretically believed to have increased probability of occurrence when levels of stress are high, but causality cannot be determined within the constraints of the design of this study.

Data analysis

The statistical analyses were conducted in Stata 15.1. First, a descriptive analysis of sample characteristics was performed. After this step, bivariate analyses were performed to calculate the proportions of highly stressed individuals (top quartile) according to each of the independent variables. Then, a multivariate analysis was carried out with Poisson regression with robust adjustment of variance to identify the factors associated with the highest stress level or the consequences of the highest stress level.1717. Barros AJ, Hirakata VN. Alternatives for logistic regression in cross-sectional studies: An empirical comparison of models that directly estimate the prevalence ratio. BMC Med Res Methodol. 2003;3:1-13. The conceptual model for these analyses is illustrated in Figure 1 .

Figure 1
Conceptual model of analysis of associated factors and possible consequences of high stress levels. Rio Grande, Brazil, 2016 (N = 1,295).

For the multivariate analysis, a hierarchical model was constructed on two levels by the backward method ( Figure 1 ).1818. Victora CG, Huttly SR, Fuchs SC, Olinto MT. The role of conceptual frameworks in epidemiological analysis: a hierarchical approach. Int J Epidemiol. 1997;26:224-7. Variables with a p-value < 0.20 were retained in the final model. The remaining variables were used for adjustment purposes to verify the effects of the highest stress level on the different outcomes (Model 1). The analysis of the consequences of stress was also adjusted for all other outcomes (Model 2) to verify the effect of stress on each outcome independently of the other outcomes. The results of crude and multivariate analyses are presented as prevalence ratios (PR) and 95% confidence intervals (95%CI).

Finally, we calculated the etiologic fraction (EF) of the stress on the physical and psychological outcomes using the formula . The EF is interpreted as the proportion of the outcome that might be reduced if the group with the highest stress level were omitted from the population. All analyses were performed considering the sample design effect and a significance level of 5% for two-tailed tests.

Data availability statement

We declare that the data used in this manuscript is available upon request from the corresponding author.

Results

The sample comprised 1,295 individuals, which corresponds to a response rate of 91.0%. Among non-respondents (9%), 6.9% were refusals and 2.1% were losses. The proportion of males was significantly higher among non-respondents than among participants (p < 0.001), with no significant difference in age (p = 0.64). Majorities of the sample were female (56.6%), had white skin color (82.9%), and were not living alone (90.4%). Almost half of the sample (41.8%) had eight years or less of schooling, 39.3% were aged between 18 and 39 years, 11.7% reported excessive alcohol consumption, 17.9% were current smokers, 31.8% watched television for three or more hours per day, and 33.3% engaged in some physical activity. Approximately one-third of the sample reported food insecurity and had visited a doctor in the previous month ( Table 1 ). The mean perceived stress score was 23.6 points (standard deviation [SD] = 7.4), and scores ranged from 3 to 50 points. The cutoff for the quartile with the highest stress level was ≥ 29 points.

Table 1
Description of the characteristics of the sample of adults aged 18 years or older from Rio Grande, Brazil, 2016 (N = 1,295).

Table 2 shows the distribution of individuals with the highest stress level, grouped by the independent variables. Individuals with food insecurity had the greatest proportion of highly stressed individuals (35%), whereas individuals who were physically active had the lowest proportion of highly stressed individuals (16%). In the crude analyses, the variables age, marital status, schooling, wealth index, physical activity, time watching television, food insecurity, and having visited a doctor were significantly associated with the highest level of stress. In the adjusted analysis, the following variables remained significant: female sex (PR = 1.51, 95%CI 1.25-1.81), age between 18 and 39 years old (PR = 1.76, 95%CI 1.26-2.46) or between 40 to 59 years old (PR = 1.60, 95%CI 1.17-2.19), schooling less than or equal to eight years (PR = 1.56, 95%CI 1.20-2.02), physical inactivity (PR = 1.51, 95%CI 1.20-1.91), watching television for three hours or more per day (PR = 1.29, 95%CI 1.12-1.50), and food insecurity (PR = 1.44, 95%CI 1.19-175).

Table 2
Crude and adjusted prevalence ratios for associations between the highest stress level and independent variables. Multivariate analysis conducted with two hierarchical levels, through Poisson regression with robust adjust for variance, accounting for design effect. Sample of adults aged 18 years or older in Rio Grande, Brazil, 2016 (N = 1,295).

Table 3 shows the prevalence of physical and psychological outcomes and their associations with the highest stress level. The most frequent outcomes were regular or poor self-rated health (33.7%), hypertension (28.1%), and obesity (23.7%). In the crude analysis, the highest stress level was significantly associated with back pain, cardiopathy, regular or poor self-rated health, poor or very poor quality of sleep, lower quality of life, sadness, and depressive symptoms. In the adjusted analysis, controlling for possible confounders (Model 1), the highest stress level was still significantly associated with these variables in addition to being associated with hypertension. In Model 2 (also adjusting for other outcomes), the highest stress level remained associated with regular or poor self-perception of health (PR = 1.53, 95%CI 1.29-1.81), poor or very poor quality of sleep (PR = 1.62, 95%CI 1.09-2.40), lower quality of life (PR = 2.70, 95%CI 2.05-3.05), sadness (PR = 2.27, 95%CI 1.43-3.57), and depressive symptoms (PR = 3.02, 95%CI 1.95-4.68). The highest stress level stress levels showed a protective effect against obesity (PR = 0.75, 95%CI 0.58-0.97).

Table 3
Crude and adjusted analysis of possible consequences of high levels of stress. Sample of adults aged 18 years or older in Rio Grande, Brazil, 2016 (N = 1,295).

Regarding the EF, the highest stress level made a substantial contribution to most outcomes ( Table 3 ). The EF was 45.6% for lower quality of life, 35.8% for depressive symptoms, 29.6% for regular or poor self-rated health, 24.2% for sadness, and 17.3% for poor or very poor quality of sleep. The results showed that stress made a low, but still significant, contribution to occurrence of obesity (EF = 2.5%).

Discussion

Main finding of this study

This study evaluated perceived stress levels of the population of a municipality in southern Brazil and attempted to identify the possible risk factors for and the consequences of high levels of stress. The mean perceived stress score in this sample was 23.6 (SD = 7.4). It was shown that female, younger, and less educated individuals had a higher probability of being more stressed. Participants who were physically inactive, watched more television, and reported food insecurity had a higher probability of being more stressed.

One of the possible consequences of high levels of stress was self-rated regular or poor health. In addition to a modest association (PR = 1.53), stress explained 29.6% of the variation in this outcome. An unexpected result was that participants with the highest stress level had a lower probability of being obese, although stress levels explained a low proportion of the variance in this outcome (only 2.5%). One of the main consequences of high levels of stress in this study was a reduction in quality of life. The most stressed participants had a 170% greater probability of having a lower quality of life, and stress alone accounted for 45.6% of the variance in this outcome. In this study, the highest stress level was significantly associated with and explained 17.3% of the variance in poor or very poor sleep quality. The most stressed individuals were two and three times more likely to present symptoms of sadness and depression, respectively, than their less stressed counterparts. In addition, the highest stress level explained a high proportion of the variance in these outcomes (24.2% for sadness and 35.8% for depression).

What is already known on this topic?

The stress scores reported in studies conducted in low and middle-income countries, such as Jordan (17.7)1919. Hattar-Pollara M, Dawani H. Cognitive appraisal of stress and health status of wage working and nonwage working women in Jordan. J Transcult Nurs. 2006;17:349-56. and India (19.3)2020. Pangtey R, Basu S, Meena G, Banerjee B. Perceived stress and its epidemiological and behavioral correlates in an urban area of Delhi, India: a community-based cross-sectional study. Indian J Psychol Med. 2020;42:80-6. were lower than that those found in this study. However, the scores reported in high-income countries, such as Italy (15.2), Germany (14.9), France (15.0), and Poland (17.6) were higher than that found in our study.2121. Marcellini F, Giuli C, Papa R, Gagliardi C, Dedoussis G, Herbein G, et al. Zinc status, psychological and nutritional assessment in old people recruited in five European countries: Zincage study. Biogerontology. 2006;7:339-45. In addition, the mean score for perceived stress in our investigation was similar to the score reported in a study conducted in Greece (25.4),2121. Marcellini F, Giuli C, Papa R, Gagliardi C, Dedoussis G, Herbein G, et al. Zinc status, psychological and nutritional assessment in old people recruited in five European countries: Zincage study. Biogerontology. 2006;7:339-45. but it should be noted that Greece was about to enter into a profound social and economic crisis when that study was conducted. Thus, it is plausible that population stress levels are closely related to the degree of social and economic development of the community, possibly due to the direct and indirect benefits of these resources on the general quality of life. In low and middle-income settings, income inequality, unequal distribution of job opportunities, and low-quality working conditions can erode the social cohesion that allows people to live and work together. This process may decrease social resources, trust, and civic participation, and increase crime and deterioration of public structures and institutions, increasing overall levels of stress in populations.

There is evidence that women report being more stressed than men,2222. Anderson NB, Belar CD, Breckler SJ, Nordal KC, Ballard D, Bufka LF, et al. Stress in America: our health at risk [Internet]. 2012 [cited 2021 Dec 7]. www.apa.org/news/press/releases/stress/2011/final-2011.pdf
www.apa.org/news/press/releases/stress/2...
possibly due to hormonal influences and social issues,2323. Altemus M. Sex differences in depression and anxiety disorders: potential biological determinants. Horm Behav. 2006;50:534-8. such as the devaluation of their work, the need for more working hours, and the objectification of their bodies.2424. Sen G, Östlin P. Gender inequity in health: why it exists and how we can change it. Glob Public Health. 2008;3 Suppl 1:1-12. Studies indicate that older people have lower levels of anxiety, depression and stress, as well as higher levels of happiness, satisfaction, and well-being,2525. Hamarat E, Thompson D, Zabrucky KM, Steele D, Matheny KB, Aysan F. Perceived stress and coping resource availability as predictors of life satisfaction in young, middle-aged, and older adults. Exp Aging Res. 2001;27:181-96. , 2626. Thomas ML, Kaufmann CN, Palmer BW, Depp CA, Martin AS, Glorioso DK, et al. Paradoxical trend for improvement in mental health with aging: a community-based study of 1,546 adults aged 21-100 years. J Clin Psychiatry. 2016;77:1019-25. which can be explained by an increase in wisdom and an increased ability to deal with daily life stressors.2727. Jeste DV, Oswald AJ. Individual and societal wisdom: explaining the paradox of human aging and high well-being. Psychiatry Interpers Biol Process. 2014;77:317-30. Finally, individuals with less education may have greater difficulty finding optimal occupations and attaining higher socioeconomic status, which may expose them to greater and more persistent psychosocial stressors.2828. Solar O, Irwin A. Conceptual framework of health determinants. In: World Health Organization (WHO). A conceptual framework for action on the social determinants of health. Geneve: WHO; 2007. p. 43-136.

Physical activity has a bidirectional relationship with stress, since physically active individuals tend to be less stressed and, consequently, are more likely to remain active.2929. Schultchen D, Reichenberger J, Mittl T, Weh TRM, Smyth JM, Blechert J, et al. Bidirectional relationship of stress and affect with physical activity and healthy eating. Br J Health Psychol. 2019;24:315-33. Individuals who spend more time in front of television tend to have higher levels of sedentary behavior (i.e., sitting and/or lying down),3030. Clark BK, Healy GN, Winkler EA, Gardiner PA, Sugiyama T, Dunstan DW, et al. Relationship of television time with accelerometer-derived sedentary time: NHANES. Med Sci Sports Exerc. 2011;43:822-8. which has also been strongly associated with high levels of stress.3131. Lee E, Kim Y. Effect of university students’ sedentary behavior on stress, anxiety, and depression. Perspect Psychiatr Care. 2019;55:164. Respondents with food insecurity may experience higher levels of prolonged and toxic stress, as they lack basic resources for survival and citizenship.3232. Whittle HJ, Sheira LA, Wolfe WR, Frongillo EA, Palar K, Merenstein D, et al. Food insecurity is associated with anxiety, stress, and symptoms of posttraumatic stress disorder in a cohort of women with or at risk of HIV in the United States. J Nutr. 2019;149:1393-403. Furthermore, food insecurity may result in insufficient intake of nutrients, generating physiological sequelae that may predispose individuals to psychological suffering.3232. Whittle HJ, Sheira LA, Wolfe WR, Frongillo EA, Palar K, Merenstein D, et al. Food insecurity is associated with anxiety, stress, and symptoms of posttraumatic stress disorder in a cohort of women with or at risk of HIV in the United States. J Nutr. 2019;149:1393-403. , 3333. Hanson KL, Connor LM. Food insecurity and dietary quality in US adults and children: A systematic review. Am J Clin Nutr. 2014;100:684-92.

With respect to the finding about obesity, the initial hypothesis was that individuals with high levels of stress would be more prone to obesity, since stress plays a role in its development and maintenance.3434. Tomiyama AJ. Stress and obesity. Annu Rev Psychol. 2019;70:703-18. Notwithstanding, the results found in this study may have occurred due to two phenomena. First, individuals who eat for comfort seem to achieve lower levels of perceived stress, which could result in people with higher BMI having lower perceived stress scores.3535. Finch LE, Tomiyama AJ. Comfort eating, psychological stress, and depressive symptoms in young adult women. Appetite. 2015;95:239-44. Second, the results may be due to a negative confounding effect, because obese people tend to have a worse perception of health,3636. Porto DB, de Arruda GA, Altimari LR, Cardoso Júnior CG. Self-perceived health among workers at a university hospital and associations with indicators of adiposity, arterial blood pressure and physical activity habits. Cienc e Saude Colet. 2016;21:1113-22. are sadder and more depressed,3737. Pereira-Miranda E, Costa PR, Queiroz VA, Pereira-Santos M, Santana ML. Overweight and obesity associated with higher depression prevalence in adults: a systematic review and meta-analysis. J Am Coll Nutr. 2017;36:223-33. and have worse quality of sleep3838. Beccuti G, Pannain S. Sleep and obesity. Curr Opin Clin Nutr Metab Care. 2011;14:402-12. and quality of life.3939. Giuli C, Papa R, Bevilacqua R, Felici E, Gagliardi C, Marcellini F, et al. Correlates of perceived health related quality of life in obese, overweight and normal weight older adults: An observational study. BMC Public Health. 2014;14:1-8. It is therefore plausible that when we control for these variables in multivariate analysis, obese people can, in fact, be less stressed.

The association between stress level and poorer self-perceived health corroborates the literature that emphasizes that self-perceived health can be referred to as a health indicator.4040. Reichert FF, Loch MR, Capilheira MF. Self-reported health status in adolescents, adults and the elderly. Cienc Saude Colet. 2012;17:3353-62. , 4141. Wilson IB. Linking clinical variables with health-related quality of life: a conceptual model of patient outcomes. JAMA. 1995;273:59-65. Regarding quality of life, both acute and chronic stress have effects that compromise health, which can affect people’s quality of life.4242. Ribeiro ÍJS, Pereira R, Freire I V., de Oliveira BG, Casotti CA, Boery EN. Stress and quality of life among university students: a systematic literature review. Health Prof Educ. 2018;4:70-7. Although low quality of life is not considered a morbidity, it is associated with a wide range of physical and mental health outcomes with corresponding implications for public health.4343. Caron J, Cargo M, Daniel M, Liu A. Predictors of quality of life in Montreal, Canada: a longitudinal study. Community Ment Health J. 2019;55:189-201.

It is important to state that sleep and stress can have a bidirectional relationship. Poor sleep quality can cause impairments such as chronic stress and multimorbidities,4444. Reis C, Dias S, Rodrigues AM, Sousa RD, Gregório MJ, Branco J, et al. Sleep duration, lifestyles and chronic diseases: a cross-sectional population-based study. Sleep Sci. 2018;11:217-30. which, in turn, can increase sleep-related problems, increasing stress. Concerning mental health, stress increases the risk of developing physical and mental disorders4545. Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE, et al. Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet. 2013;382:1575-86. and is strongly associated with depression44. Liu RT, Alloy LB. Stress generation in depression: a systematic review of the empirical literature and recommendations for future study. Clin Psychol Rev. 2010;30:582-93. , 4646. Gold PW, Machado-Vieira R, Pavlatou MG. Clinical and biochemical manifestations of depression: relation to the neurobiology of stress. Neural Plast. 2015;2015:1-11. , 4747. Jesulola E, Micalos P, Baguley IJ. Understanding the pathophysiology of depression: From monoamines to the neurogenesis hypothesis model - are we there yet? Behav Brain Res. 2018;341:79-90. and suicidal thoughts.4848. Dumith SC, Demenech LM, Carpena MX, Nomiyama S, Neiva-Silva L, Loret de Mola C. Suicidal thought in southern Brazil: who are the most susceptible? J Affect Disord. 2020;1:610-6. There is a biological mechanism for these effects, since stress causes neurochemical, immunological, and autonomic changes related to emotional and cognitive regulation, which may lead to manifestations of depressive symptoms.4949. Beck a. T, Bredemeier K. A unified model of depression: integrating clinical, cognitive, biological, and evolutionary perspectives. Clin Psychol Sci. 2016;4:596-619.

What does this study add?

It should be highlighted that this is the first study of the risk factors for and consequences of perceived stress to be conducted in a representative sample of a Brazilian municipality. Etiologic factor estimates of the possible consequences associated with high levels of stress can also be especially interesting because they enable us to forecast the proportion of each outcome that would be reduced if we were able to eliminate high levels of stress.

This sample had a high mean perceived stress score, especially when compared to samples from high-income countries. Individuals who were female, younger, less educated, physically inactive, and subject to food insecurity, and people who watched more television per day had a higher probability of being more stressed. Consequences related to the highest stress level were regular or poor self-perceived health, poor or very poor sleep quality, lower quality of life, sadness, and depression. Stress alone explained a large proportion of the variability in these outcomes. An unexpected result was that the highest stress level was associated with a lower probability of being obese, even though this association was weak and poorly explained by stress.

This article sought to present the importance that stress plays throughout several domains of health and relate it to a wide range of individual characteristics and consequences. Results of this investigation can have at least three implications: First, strengthening public policies that promote gender equality, education and occupation opportunities for younger individuals, and access to healthy food, physical activities, and diverse leisure options may reduce stress levels in the population. These may be interpreted as broad recommendations, but without these basic actions, targeted interventions are likely to be less effective (or ineffective). Second, stress seems to play an important role in the development of several negative health outcomes. It can therefore be used as a proxy to screen for psychological and physical comorbidities by health professionals, considering that more stressed people were more likely to report poor health, poor quality of sleep, lower quality of life, and sadness and depression. Third, specific interventions targeting reductions in stress (at the individual and collective levels) can reduce the burden of physical and psychological suffering, considering that stress alone contributed to a significant proportion of the abovementioned consequences. Including psychologists in the family health strategy could facilitate community access to mental health assessment, prevention, and treatment, improving people’s overall quality of life.

Limitations of this study

The findings of this investigation should be interpreted in light of its limitations. First, all variables were measured through self-report, which might produce less precise results. However, most large-scale epidemiological studies collect data using self-report measures, enabling us to compare our results with existing findings. Second, work-related characteristics were not assessed in this investigation, and considering its possible impacts on stress, this should be considered as a limitation. Future research conducted within the same (or a similar) context should address this topic in the investigation. Work conditions may influence key factors significantly associated with stress identified in this study. Job opportunities can be unequally distributed according to gender, age, and educational level, especially in low and middle-income countries2828. Solar O, Irwin A. Conceptual framework of health determinants. In: World Health Organization (WHO). A conceptual framework for action on the social determinants of health. Geneve: WHO; 2007. p. 43-136. such as Brazil. It can therefore result in better (or worse) material conditions (access to household assets and availability of healthy food), and in higher (or lower) opportunities to engage in physical activities and in leisure activities (other than watching television). Finally, the data were collected in 2016. Despite possible concerns regarding timeliness, this study is still relevant because, apart from shedding light on an important issue, it registers stress levels in a population in the pre covid-19 pandemic setting, allowing future comparisons of scenarios.

Acknowledgments

This study was funded by the Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS; grant 16/2551-0000359-9). SCD is a research productivity fellow at the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

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Publication Dates

  • Publication in this collection
    23 Sept 2022
  • Date of issue
    2022

History

  • Received
    19 Feb 2021
  • Accepted
    26 Apr 2021
Associação de Psiquiatria do Rio Grande do Sul Av. Ipiranga, 5311/202, 90610-001 Porto Alegre RS/ Brasil, Tel./Fax: (55 51) 3024 4846 - Porto Alegre - RS - Brazil
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