IMPACTO DEL COVID-19 EN PACIENTES COM CÁNCER: REVISIÓN DE ALCANCE

revisión del alcance, basada en el marco teórico del Instituto Joanna Briggs, registrado en el Open Science Framework (osf.io/64ems/). Se realizó una búsqueda en nueve bases de datos y bibliotecas virtuales, en los meses de junio y julio de 2020.

Resultados:

se seleccionaron 25 estudios que respondieron a la pregunta orientadora, demostrando que la neoplasia más afectada por la infección fue la pulmonar, y las principales manifestaciones clínicas fueron fiebre, tos, disnea, diarrea y fatiga. En cuanto al tratamiento, los antivirales y los antibióticos fueron los más mencionados. Todos los estudios citan la vulnerabilidad de los pacientes con cáncer diagnosticados con COVID-19, con una tasa de mortalidad del 21-30% en la mayoría de los estudios y un pronóstico de progresión a formas graves de la enfermedad. Aún así, la mayoría de los pacientes evolucionaron para curarse, aunque en los casos graves la evolución fue de peor pronóstico, en comparación con la población general.

Conclusión:

este estudio demostró inseguridad en el tratamiento de la enfermedad debido a la variedad de medicamentos utilizados y la incertidumbre sobre si continuar el tratamiento neoplásico durante este período.

DESCRIPTORES:
Infecciones por coronavirus; Pandemias; Oncología; Neoplasias; Signos y síntomas

PCC	MESH/DeCS		Keywords
Population	Medical Oncology/Oncologia	OR	Oncological patients
	AND
Concept	Signs and symptoms/Sinais e Sintomas
	OR
	Therapeutics/Terapêutica
	OR
	Prognosis/Prognóstico
	AND
Context	Coronavirus/Coronavírus
	OR
	Pandemics/Pandemias	OR	COVID-19

Data source	Syntax adopted
Web of Science	TS: (Medical Oncology OR Oncological patients) AND TS: (Signs and symptoms OR Therapeutics OR Prognosis) AND TS: (Coronavirus OR COVID-19 OR Pandemics)
LILACS*	Medical Oncology [Words] OR Oncological patients [Words] AND Signs and symptoms [Words] OR Therapeutics [Words] OR Prognosis [Words] AND Coronavirus [Words] OR COVID-19 [Words] or Pandemics [Words]
Scopus†	(TITLE-ABS-KEY (Medical Oncology OR Oncological patients) AND TITLE-ABS-KEY (Signs and symptoms OR Therapeutics OR Prognosis)) AND (TITLE-ABS-KEY (Coronavirus OR COVID-19 OR Pandemics))
MEDLINE‡	(“Medical Oncology” [All Fields] OR “Oncological patients” [All Fields]) AND (“Signs and symptoms” [All Fields] OR “Therapeutics” [All Fields] OR “Prognosis” [All Fields]) AND (“Coronavirus” [All Fields] OR “COVID-19” [All Fields] OR “Pandemics” [All Fields])
CINAHL§	(Medical Oncology OR Oncological patients) AND (Signs and symptoms OR Therapeutics OR Prognosis) AND (Coronavirus OR COVID-19 OR Pandemics)
Science Direct	(SU (Medical Oncology OR Oncological patients)) AND (SU (Signs and symptoms OR Therapeutics OR Prognosis)) AND (SU (Coronavirus OR COVID-19 OR Pandemics))
SciELO\|\|	(*”Medical Oncology” OR “Oncological patients”) AND (“Signs and symptoms” OR “Therapeutics” OR “Prognosis”) AND (“Coronavirus” OR “COVID-19” OR “Pandemics”)
Cochrane Library	(Medical Oncology OR (Oncological patients)) AND (Signs and symptoms OR (Therapeutics OR (Prognosis)) AND (Coronavirus OR (COVID-19) OR (Pandemics))
Wiley¶	(“Medical Oncology” OR “Oncological patients”) AND (“Signs and symptoms” OR “Therapeutics” OR “Prognosis”) AND (“Coronavirus” OR “COVID-19” OR “Pandemics”)
Catalog of Theses and Dissertations (CAPES)	(“Medical Oncology” OR “Oncological patients”) AND (“Signs and symptoms” OR “Therapeutics” OR “Prognosis”) AND (“Coronavirus” OR “COVID-19” OR “Pandemics”)
Google Scholar	(“Medical Oncology” OR “Oncological patients”) AND (“Signs and symptoms” OR “Therapeutics” OR “Prognosis”) AND (“Coronavirus” OR “COVID-19” OR “Pandemics”)

ID	Title	Country Year	Data source	Study sample	Level of evidence/Degree of recommendation
A1	High mortality rate in patients with cancer with symptoms of COVID-19 with or without detectable SARS-COV-2 on RT-PCR1313. Assaad S, Avrillon V, Fournier M-L, Mastroianni B, Russias B, Swalduz A, et al. High mortality rate in cancer patients with symptoms of COVID-19 with or without detectable SARS-COV-2 on RT-PCR. Eur J Cancer [Internet]. 2020 [cited 2020 Jul 01];135:251-9. Available from: https://doi.org/10.1016/j.ejca.2020.05.028 https://doi.org/10.1016/j.ejca.2020.05.0...	France 2020	Web of Science	302	Cohort study 2B/B
A2	Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak1414. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak. Cancer Discov [Internet]. 2020 [cited 2020 Jul 10];10(6):783-91. Available from: https://doi.org/10.1158/2159-8290.CD-20-0422 https://doi.org/10.1158/2159-8290.CD-20-...	China 2020	Web of Science	105	Cohort study 2B/B
A3	COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study1515. Garassino MC, Whisenant JG, Huang L-C, Trama A, Torri V, Agustoni F, et al. COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 11];21(7):914-22. Available from: https://doi.org/10.1016/S1470-2045(20)30314-4 https://doi.org/10.1016/S1470-2045(20)30...	Italy 2020	Web of Science	200	Cohort study 2B/B
A4	COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study1616. Lee LYW, Cazier JB, Starkey T, Turnbull CD, Kerr R, Middleton G. COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study. Lancet [Internet]. 2020 [cited 2020 Jul 11];395(10241):1919-26. Available from: https://doi.org/10.1016/S0140-6736(20)31173-9 https://doi.org/10.1016/S0140-6736(20)31...	United Kingdom 2020	Web of Science	800	Cohort study 2B/B
A5	Case Fatality Rate of Patients with cancer with COVID-19 in a New York Hospital System1717. Mehta V, Goel S, Kabarriti R, Cole D, Goldfinger M, Acuna-Villaorduna A, et al. Case fatality rate of cancer patients with COVID-19 in a New York hospital system. Cancer Discov [Internet]. 2020 [cited 2020 Jul 09];10:93541. Available from: doi: Available from: doi: https://doi.org/10.1158/2159-8290.cd-20-0516 https://doi.org/10.1158/2159-8290.cd-20-...	USA* 2020	Web of Science	218	Cohort study 2B/B
A6	Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study1818. Tian J, Yuan X, Xiao J, Zhong Q, Yang C, Liu B, et al. Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):893-903. Available from: https://doi.org/10.1016/S1470-2045(20)30309-0 https://doi.org/10.1016/S1470-2045(20)30...	China 2020	Web of Science	232	Cohort study 2B/B
A7	Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study1919. Yang K, Sheng Y, Huang C, Jin Y, Xiong N, Jiang K, et al. Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):904-13. Available from: https://doi.org/10.1016/S1470-2045(20)30310-7 https://doi.org/10.1016/S1470-2045(20)30...	China 2020	Web of Science	205	Cohort study 2B/B
A8	SARS-CoV-2 infection in patients with cancer undergoing active treatment: analysis of clinical features and predictive factors for severe respiratory failure and death2020. Yarza R, Bover M, Paredes D, López-López F, Jara-Casas D, Castelo-Loureiro A, et al. SARS-CoV-2 infection in cancer patients undergoing active treatment: analysis of clinical features and predictive factors for severe respiratory failure and death. Eur J Cancer [Internet]. 2020 [cited 2020 Jul 12];135:242-50. Available from: https://doi.org/10.1016/j.ejca.2020.06.001 https://doi.org/10.1016/j.ejca.2020.06.0...	Spain 2020	Web of Science	63	Cohort study 2B/B
A9	Clinical characteristics of COVID-19-infected patients with cancer: a retrospective case study in three hospitals within Wuhan, China 2121. Zhang L, Zhu F, Xie L, Wang C, Wang J, Chen R, et al. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Ann Oncol [Internet]. 2020 [cited 2020 Jul 13];31(7):894-901. Available from: https://doi.org/10.1016/j.annonc.2020.03.296 https://doi.org/10.1016/j.annonc.2020.03...	China 2020	Web of Science	28	Cohort study 2B/B
A10	COVID-19 in persons with haematological cancers2222. He W, Chen L, Chen L, Yuan G, Fang Y, Chen W, et al. COVID-19 in persons with haematological cancers. Leukemia [Internet]. 2020 [cited 2020 Jul 13];34(6):1637-45. Available from: https://doi.org/10.1038/s41375-020-0836-7 https://doi.org/10.1038/s41375-020-0836-...	China 2020	MEDLINE†	13	Cohort study 2B/B
A11	Mortalidad por covid-19 en pacientes con cáncer en un hospital de Madrid durante las primeras 3 semanas de epidemic 23 23. Álvarez LMA, Revuelta RJ, Portero OB, Méndez PC, Montero SG, Alfonso LA. Mortalidad por covid-19 en pacientes con cáncer en un hospital de Madrid durante las primeras 3 semanas de epidemia. Med Clin [Internet]. 2020 [cited 2020 Jul 13];155(5):202-4. Available from: https://doi.org/10.1016/j.medcli.2020.05.005 https://doi.org/10.1016/j.medcli.2020.05...	Spain 2020	Science Direct	15	Retrospective 3A/B
A12	Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study2424. Kuderer NM, Choueiri TK, Shah DP, Shyr Y, Rubinstein SM, Rivera DR, et al. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study. Lancet [Internet]. 2020 [cited 2020 Jul 04];395(10241):1907-18. Available from: https://doi.org/10.1016/S0140-6736(20)31187-9 https://doi.org/10.1016/S0140-6736(20)31...	USA* 2020	Science Direct	928	Cohort study 2B/B
A13	COVID-19 in patients with lung cancer2525. Luo J, Rizvi H, Preeshagul IR, Egger JV, Hoyos D, Bandlamudi C, et al. COVID-19 in patients with lung cancer. Ann Oncol [Internet]. 2020 [cited 2020 Jul 10];31(10):P1386-96 Available from: https://doi.org/10.1016/j.annonc.2020.06.007 https://doi.org/10.1016/j.annonc.2020.06...	USA* 2020	Science Direct	102	Retrospective 3A/B
A14	Determinants of COVID-19 disease severity in patients with cancer2626. Robilotti EV, Babady NE, Mead PA, Rolling T, Perez-Johnston R, Bernardes M, et al. Determinants of COVID-19 disease severity in patients with cancer. Nat Med [Internet]. 2020 [cited 2020 Jul 12];26:1218-23. Available from: https://doi.org/10.1038/s41591-020-0979-0 https://doi.org/10.1038/s41591-020-0979-...	USA* 2020	Science Direct	423	Cohort study 2B/B
A15	Covid-19 and lung cancer: A greater fatality rate 2727. Rogado J, Pangua C, Serrano-Montero G, Obispo B, Marino AM, Pérez-Pérez M, et al. Covid-19 and lung cancer: A greater fatality rate? Lung Cancer [Internet]. 2020 [cited 2020 Jul 12];146:19-22. Available from: https://doi.org/10.1016/j.lungcan.2020.05.034 https://doi.org/10.1016/j.lungcan.2020.0...	Spain 2020	Science Direct	17	Cohort study 2B/B
A16	Outcomes of Novel Coronavirus Disease 2019 (COVID-19) Infection in 107 Patients with Cancer from Wuhan, China2828. Hang H, Wang L, Chen Y, Wu Q, Chen G, Shen X, et al. Outcomes of novel coronavirus disease 2019 (COVID-19) infection in 107 patients with cancer from Wuhan, China. Cancer [Internet]. 2020 [cited 2020 Jul 12];126(17):4023-31. Available from: https://doi.org/10.1002/cncr.33042 https://doi.org/10.1002/cncr.33042...	China 2020	Wiley Online Library	107	Retrospective 3A/B
A17	Clinical characteristics and outcomes of patients with cancer with COVID-192929. Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X. Clinical characteristics and outcomes of cancer patients with COVID-19. J Med Virol [Internet]. 2020 [cited 2020 Jul 12];92(10):2067-73. Available from: https://doi.org/10.1002/jmv.25972 https://doi.org/10.1002/jmv.25972...	China 2020	Wiley Online Library	52	Retrospective 3A/B
A18	Characteristics and outcome of SARS-CoV-2 infection in patients with cancer3030. Basse C, Diakite S, Servois V, Frelaut M, Noret A, Bellesoeur A, et al. Characteristics and outcome of SARS-CoV-2 infection in cancer patients. medRxiv [Internet]. 2020 [cited 2020 Jul 12];2020.05.14.20101576. Available from: https://doi.org/10.1101/2020.05.14.20101576 https://doi.org/10.1101/2020.05.14.20101...	China 2020	Google Chrome Scholar	141	Cohort study 2B/B
A19	Infection rate and clinical management of patients with cancer during the COVID-19 pandemic: experience from a tertiary care hospital in northern Italy3131. Fong D, Rauch S, Petter C, Haspinger E, Alber M, Mitterer M. Infection rate and clinical management of cancer patients during the COVID-19 pandemic: experience from a tertiary care hospital in northern Italy. ESMO Open [Internet]. 2020 [cited 2020 Jul 13];5(3):e000810. Available from: https://doi.org/10.1136/esmoopen-2020-000810 https://doi.org/10.1136/esmoopen-2020-00...	Italy 2020	Google Chrome Scholar	81	Retrospective 3A/B
A20	Characteristics and outcomes of coronavirus disease 2019 (COVID-19) patients with cancer: A single-center retrospective observational study in Tokyo, Japan3232. Nakamura S, Kanemasa Y, Atsuta Y, Fujiwara S, Tanaka M, Fukushima K, et al. Characteristics and outcomes of coronavirus disease 2019 (COVID-19) patients with cancer: a single-center retrospective observational study in Tokyo, Japan. Research Square [Internet]. 2020 [cited 2020 Jul 13] Available from: https://doi.org/10.21203/rs.3.rs-39157/v1 https://doi.org/10.21203/rs.3.rs-39157/v...	Japan 2020	Google Chrome Scholar	32	Cohort study 2B/B
A21	Presenting Features and Early Mortality from SARS-CoV-2 Infection in Patients with cancer during the Initial Stage of the COVID-19 Pandemic in EuropA333. Brito SBP, Braga IO, Cunha CC, Palácio MAV, Takenami I. Pandemia da COVID-19: o maior desafio do século XXI. Vigil Sanit Debate [Internet]. 2020 [cited 2020 Jul 03];8(2):54-63. Available from: https://doi.org/10.22239/2317-269x.01531 https://doi.org/10.22239/2317-269x.01531...	Italy Spain 2020	Google Chrome Scholar	204	Cohort study 2B/B
A22	Covid-19 transmission, outcome and associated risk factors in patients with cancer at the first month of the pandemic in a Spanish hospital in Madrid3434. Rogado J, Obispo B, Pangua C, Serrano-Montero G, Martín Marino A, Pérez-Pérez M, et al. Covid-19 transmission, outcome and associated risk factors in cancer patients at the first month of the pandemic in a Spanish hospital in Madrid. Clin Transl Oncol [Internet]. 2020 [cited 2020 Jul 13];22:2364-68. Available from: https://doi.org/10.1007/s12094-020-02381-z https://doi.org/10.1007/s12094-020-02381...	Spain 2020	Google Chrome Scholar	45	Cohort study 2B/B
A23	Coronavirus disease-2019 in patients with cancer. A report of the first 25 patients with cancer in a western country (Italy)3535. Stroppa EM, Toscani I, Citterio C, Anselmi E, Zaffignani E, Codeluppi M, et al. Coronavirus disease-2019 in cancer patients. A report of the first 25 cancer patients in a western country (Italy). Future Oncol [Internet]. 2020 [cited 2020 Jul 09];16(20):1425-32. Available from: https://doi.org/10.2217/fon-2020-0369 https://doi.org/10.2217/fon-2020-0369...	Italy 2020	Google Chrome Scholar	25	Cohort study 2B/B
A24	Systematic investigations of COVID-19 in 283 patients with cancer3636. Wang J, Song Q, Chen Y, Wang Z, Chu Q, Gong H, et al. Systematic investigations of COVID-19 in 283 cancer patients [Internet]. medRxiv [Internet]. 2020 [cited 2020 Jul 09];2020.04.28.20083246. Available from: https://doi.org/10.1101/2020.04.28.20083246 https://doi.org/10.1101/2020.04.28.20083...	China 2020	Google Chrome Scholar	283	Retrospective 3A/B
A25	A Multicenter Study of Coronavirus Disease 2019 Outcomes of Patients with cancer in Wuhan, China3737. Zhang H-Y, Wang L-W, Chen Y-Y, Shen X-K, Wang Q, Yan Y-Q, et al. A multicentre study of 2019 novel Coronavirus disease outcomes of cancer patients in Wuhan, China. medRxiv [Internet]. 2020 [cited 2020 Jul 09];2020.03.21.20037127. Available from: https://doi.org/10.1101/2020.03.21.20037127 https://doi.org/10.1101/2020.03.21.20037...	China 2020	Google Chrome Scholar	67	Retrospective 3A/B

Type of cancer	ID of articles	N (%)
Lung	A11313. Assaad S, Avrillon V, Fournier M-L, Mastroianni B, Russias B, Swalduz A, et al. High mortality rate in cancer patients with symptoms of COVID-19 with or without detectable SARS-COV-2 on RT-PCR. Eur J Cancer [Internet]. 2020 [cited 2020 Jul 01];135:251-9. Available from: https://doi.org/10.1016/j.ejca.2020.05.028 https://doi.org/10.1016/j.ejca.2020.05.0... , A21414. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak. Cancer Discov [Internet]. 2020 [cited 2020 Jul 10];10(6):783-91. Available from: https://doi.org/10.1158/2159-8290.CD-20-0422 https://doi.org/10.1158/2159-8290.CD-20-... , A31515. Garassino MC, Whisenant JG, Huang L-C, Trama A, Torri V, Agustoni F, et al. COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 11];21(7):914-22. Available from: https://doi.org/10.1016/S1470-2045(20)30314-4 https://doi.org/10.1016/S1470-2045(20)30... , A41616. Lee LYW, Cazier JB, Starkey T, Turnbull CD, Kerr R, Middleton G. COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study. Lancet [Internet]. 2020 [cited 2020 Jul 11];395(10241):1919-26. Available from: https://doi.org/10.1016/S0140-6736(20)31173-9 https://doi.org/10.1016/S0140-6736(20)31... , A51717. Mehta V, Goel S, Kabarriti R, Cole D, Goldfinger M, Acuna-Villaorduna A, et al. Case fatality rate of cancer patients with COVID-19 in a New York hospital system. Cancer Discov [Internet]. 2020 [cited 2020 Jul 09];10:93541. Available from: doi: Available from: doi: https://doi.org/10.1158/2159-8290.cd-20-0516 https://doi.org/10.1158/2159-8290.cd-20-... , A71919. Yang K, Sheng Y, Huang C, Jin Y, Xiong N, Jiang K, et al. Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):904-13. Available from: https://doi.org/10.1016/S1470-2045(20)30310-7 https://doi.org/10.1016/S1470-2045(20)30... , A82020. Yarza R, Bover M, Paredes D, López-López F, Jara-Casas D, Castelo-Loureiro A, et al. SARS-CoV-2 infection in cancer patients undergoing active treatment: analysis of clinical features and predictive factors for severe respiratory failure and death. Eur J Cancer [Internet]. 2020 [cited 2020 Jul 12];135:242-50. Available from: https://doi.org/10.1016/j.ejca.2020.06.001 https://doi.org/10.1016/j.ejca.2020.06.0... , A92121. Zhang L, Zhu F, Xie L, Wang C, Wang J, Chen R, et al. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Ann Oncol [Internet]. 2020 [cited 2020 Jul 13];31(7):894-901. Available from: https://doi.org/10.1016/j.annonc.2020.03.296 https://doi.org/10.1016/j.annonc.2020.03... , A112323. Álvarez LMA, Revuelta RJ, Portero OB, Méndez PC, Montero SG, Alfonso LA. Mortalidad por covid-19 en pacientes con cáncer en un hospital de Madrid durante las primeras 3 semanas de epidemia. Med Clin [Internet]. 2020 [cited 2020 Jul 13];155(5):202-4. Available from: https://doi.org/10.1016/j.medcli.2020.05.005 https://doi.org/10.1016/j.medcli.2020.05... , A122424. Kuderer NM, Choueiri TK, Shah DP, Shyr Y, Rubinstein SM, Rivera DR, et al. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study. Lancet [Internet]. 2020 [cited 2020 Jul 04];395(10241):1907-18. Available from: https://doi.org/10.1016/S0140-6736(20)31187-9 https://doi.org/10.1016/S0140-6736(20)31... , A132525. Luo J, Rizvi H, Preeshagul IR, Egger JV, Hoyos D, Bandlamudi C, et al. COVID-19 in patients with lung cancer. Ann Oncol [Internet]. 2020 [cited 2020 Jul 10];31(10):P1386-96 Available from: https://doi.org/10.1016/j.annonc.2020.06.007 https://doi.org/10.1016/j.annonc.2020.06... , A142626. Robilotti EV, Babady NE, Mead PA, Rolling T, Perez-Johnston R, Bernardes M, et al. Determinants of COVID-19 disease severity in patients with cancer. Nat Med [Internet]. 2020 [cited 2020 Jul 12];26:1218-23. Available from: https://doi.org/10.1038/s41591-020-0979-0 https://doi.org/10.1038/s41591-020-0979-... , A152727. Rogado J, Pangua C, Serrano-Montero G, Obispo B, Marino AM, Pérez-Pérez M, et al. Covid-19 and lung cancer: A greater fatality rate? Lung Cancer [Internet]. 2020 [cited 2020 Jul 12];146:19-22. Available from: https://doi.org/10.1016/j.lungcan.2020.05.034 https://doi.org/10.1016/j.lungcan.2020.0... , A162828. Hang H, Wang L, Chen Y, Wu Q, Chen G, Shen X, et al. Outcomes of novel coronavirus disease 2019 (COVID-19) infection in 107 patients with cancer from Wuhan, China. Cancer [Internet]. 2020 [cited 2020 Jul 12];126(17):4023-31. Available from: https://doi.org/10.1002/cncr.33042 https://doi.org/10.1002/cncr.33042... , A172929. Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X. Clinical characteristics and outcomes of cancer patients with COVID-19. J Med Virol [Internet]. 2020 [cited 2020 Jul 12];92(10):2067-73. Available from: https://doi.org/10.1002/jmv.25972 https://doi.org/10.1002/jmv.25972... , A183030. Basse C, Diakite S, Servois V, Frelaut M, Noret A, Bellesoeur A, et al. Characteristics and outcome of SARS-CoV-2 infection in cancer patients. medRxiv [Internet]. 2020 [cited 2020 Jul 12];2020.05.14.20101576. Available from: https://doi.org/10.1101/2020.05.14.20101576 https://doi.org/10.1101/2020.05.14.20101... , A193131. Fong D, Rauch S, Petter C, Haspinger E, Alber M, Mitterer M. Infection rate and clinical management of cancer patients during the COVID-19 pandemic: experience from a tertiary care hospital in northern Italy. ESMO Open [Internet]. 2020 [cited 2020 Jul 13];5(3):e000810. Available from: https://doi.org/10.1136/esmoopen-2020-000810 https://doi.org/10.1136/esmoopen-2020-00... , A203232. Nakamura S, Kanemasa Y, Atsuta Y, Fujiwara S, Tanaka M, Fukushima K, et al. Characteristics and outcomes of coronavirus disease 2019 (COVID-19) patients with cancer: a single-center retrospective observational study in Tokyo, Japan. Research Square [Internet]. 2020 [cited 2020 Jul 13] Available from: https://doi.org/10.21203/rs.3.rs-39157/v1 https://doi.org/10.21203/rs.3.rs-39157/v... , A213333. Pinato DJ, Lee AJX, Biello F, Seguí E, Aguilar-Company J, Carbó A, et al. Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe. Cancers [Internet]. 2020 [cited 2020 Jul 13];12(7):1841. Available from: https://doi.org/10.3390/cancers12071841 https://doi.org/10.3390/cancers12071841... , A223434. Rogado J, Obispo B, Pangua C, Serrano-Montero G, Martín Marino A, Pérez-Pérez M, et al. Covid-19 transmission, outcome and associated risk factors in cancer patients at the first month of the pandemic in a Spanish hospital in Madrid. Clin Transl Oncol [Internet]. 2020 [cited 2020 Jul 13];22:2364-68. Available from: https://doi.org/10.1007/s12094-020-02381-z https://doi.org/10.1007/s12094-020-02381... , A233535. Stroppa EM, Toscani I, Citterio C, Anselmi E, Zaffignani E, Codeluppi M, et al. Coronavirus disease-2019 in cancer patients. A report of the first 25 cancer patients in a western country (Italy). Future Oncol [Internet]. 2020 [cited 2020 Jul 09];16(20):1425-32. Available from: https://doi.org/10.2217/fon-2020-0369 https://doi.org/10.2217/fon-2020-0369... , A243636. Wang J, Song Q, Chen Y, Wang Z, Chu Q, Gong H, et al. Systematic investigations of COVID-19 in 283 cancer patients [Internet]. medRxiv [Internet]. 2020 [cited 2020 Jul 09];2020.04.28.20083246. 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Head and neck	A51717. Mehta V, Goel S, Kabarriti R, Cole D, Goldfinger M, Acuna-Villaorduna A, et al. Case fatality rate of cancer patients with COVID-19 in a New York hospital system. Cancer Discov [Internet]. 2020 [cited 2020 Jul 09];10:93541. Available from: doi: Available from: doi: https://doi.org/10.1158/2159-8290.cd-20-0516 https://doi.org/10.1158/2159-8290.cd-20-... , A71919. Yang K, Sheng Y, Huang C, Jin Y, Xiong N, Jiang K, et al. Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):904-13. Available from: https://doi.org/10.1016/S1470-2045(20)30310-7 https://doi.org/10.1016/S1470-2045(20)30... , A82020. Yarza R, Bover M, Paredes D, López-López F, Jara-Casas D, Castelo-Loureiro A, et al. SARS-CoV-2 infection in cancer patients undergoing active treatment: analysis of clinical features and predictive factors for severe respiratory failure and death. Eur J Cancer [Internet]. 2020 [cited 2020 Jul 12];135:242-50. Available from: https://doi.org/10.1016/j.ejca.2020.06.001 https://doi.org/10.1016/j.ejca.2020.06.0... , A92121. Zhang L, Zhu F, Xie L, Wang C, Wang J, Chen R, et al. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Ann Oncol [Internet]. 2020 [cited 2020 Jul 13];31(7):894-901. Available from: https://doi.org/10.1016/j.annonc.2020.03.296 https://doi.org/10.1016/j.annonc.2020.03... , A162828. Hang H, Wang L, Chen Y, Wu Q, Chen G, Shen X, et al. Outcomes of novel coronavirus disease 2019 (COVID-19) infection in 107 patients with cancer from Wuhan, China. Cancer [Internet]. 2020 [cited 2020 Jul 12];126(17):4023-31. Available from: https://doi.org/10.1002/cncr.33042 https://doi.org/10.1002/cncr.33042... , A172929. Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X. Clinical characteristics and outcomes of cancer patients with COVID-19. J Med Virol [Internet]. 2020 [cited 2020 Jul 12];92(10):2067-73. Available from: https://doi.org/10.1002/jmv.25972 https://doi.org/10.1002/jmv.25972... , A183030. Basse C, Diakite S, Servois V, Frelaut M, Noret A, Bellesoeur A, et al. Characteristics and outcome of SARS-CoV-2 infection in cancer patients. medRxiv [Internet]. 2020 [cited 2020 Jul 12];2020.05.14.20101576. Available from: https://doi.org/10.1101/2020.05.14.20101576 https://doi.org/10.1101/2020.05.14.20101... , A213333. Pinato DJ, Lee AJX, Biello F, Seguí E, Aguilar-Company J, Carbó A, et al. Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe. Cancers [Internet]. 2020 [cited 2020 Jul 13];12(7):1841. Available from: https://doi.org/10.3390/cancers12071841 https://doi.org/10.3390/cancers12071841...	8 (32)
Prostate	A82020. Yarza R, Bover M, Paredes D, López-López F, Jara-Casas D, Castelo-Loureiro A, et al. SARS-CoV-2 infection in cancer patients undergoing active treatment: analysis of clinical features and predictive factors for severe respiratory failure and death. Eur J Cancer [Internet]. 2020 [cited 2020 Jul 12];135:242-50. Available from: https://doi.org/10.1016/j.ejca.2020.06.001 https://doi.org/10.1016/j.ejca.2020.06.0... , A92121. Zhang L, Zhu F, Xie L, Wang C, Wang J, Chen R, et al. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Ann Oncol [Internet]. 2020 [cited 2020 Jul 13];31(7):894-901. Available from: https://doi.org/10.1016/j.annonc.2020.03.296 https://doi.org/10.1016/j.annonc.2020.03... A112323. Álvarez LMA, Revuelta RJ, Portero OB, Méndez PC, Montero SG, Alfonso LA. Mortalidad por covid-19 en pacientes con cáncer en un hospital de Madrid durante las primeras 3 semanas de epidemia. Med Clin [Internet]. 2020 [cited 2020 Jul 13];155(5):202-4. Available from: https://doi.org/10.1016/j.medcli.2020.05.005 https://doi.org/10.1016/j.medcli.2020.05... , A122424. Kuderer NM, Choueiri TK, Shah DP, Shyr Y, Rubinstein SM, Rivera DR, et al. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study. Lancet [Internet]. 2020 [cited 2020 Jul 04];395(10241):1907-18. Available from: https://doi.org/10.1016/S0140-6736(20)31187-9 https://doi.org/10.1016/S0140-6736(20)31... , A142626. Robilotti EV, Babady NE, Mead PA, Rolling T, Perez-Johnston R, Bernardes M, et al. Determinants of COVID-19 disease severity in patients with cancer. Nat Med [Internet]. 2020 [cited 2020 Jul 12];26:1218-23. Available from: https://doi.org/10.1038/s41591-020-0979-0 https://doi.org/10.1038/s41591-020-0979-... , A172929. Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X. Clinical characteristics and outcomes of cancer patients with COVID-19. J Med Virol [Internet]. 2020 [cited 2020 Jul 12];92(10):2067-73. Available from: https://doi.org/10.1002/jmv.25972 https://doi.org/10.1002/jmv.25972... , A203232. Nakamura S, Kanemasa Y, Atsuta Y, Fujiwara S, Tanaka M, Fukushima K, et al. Characteristics and outcomes of coronavirus disease 2019 (COVID-19) patients with cancer: a single-center retrospective observational study in Tokyo, Japan. Research Square [Internet]. 2020 [cited 2020 Jul 13] Available from: https://doi.org/10.21203/rs.3.rs-39157/v1 https://doi.org/10.21203/rs.3.rs-39157/v... , A223434. Rogado J, Obispo B, Pangua C, Serrano-Montero G, Martín Marino A, Pérez-Pérez M, et al. Covid-19 transmission, outcome and associated risk factors in cancer patients at the first month of the pandemic in a Spanish hospital in Madrid. Clin Transl Oncol [Internet]. 2020 [cited 2020 Jul 13];22:2364-68. Available from: https://doi.org/10.1007/s12094-020-02381-z https://doi.org/10.1007/s12094-020-02381...	8 (32)
Thyroid	A21414. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak. Cancer Discov [Internet]. 2020 [cited 2020 Jul 10];10(6):783-91. Available from: https://doi.org/10.1158/2159-8290.CD-20-0422 https://doi.org/10.1158/2159-8290.CD-20-... , A71919. Yang K, Sheng Y, Huang C, Jin Y, Xiong N, Jiang K, et al. Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):904-13. Available from: https://doi.org/10.1016/S1470-2045(20)30310-7 https://doi.org/10.1016/S1470-2045(20)30... , A243636. Wang J, Song Q, Chen Y, Wang Z, Chu Q, Gong H, et al. Systematic investigations of COVID-19 in 283 cancer patients [Internet]. medRxiv [Internet]. 2020 [cited 2020 Jul 09];2020.04.28.20083246. Available from: https://doi.org/10.1101/2020.04.28.20083246 https://doi.org/10.1101/2020.04.28.20083...	3 (12)
Comorbidities
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Álvarez LMA, Revuelta RJ, Portero OB, Méndez PC, Montero SG, Alfonso LA. Mortalidad por covid-19 en pacientes con cáncer en un hospital de Madrid durante las primeras 3 semanas de epidemia. Med Clin [Internet]. 2020 [cited 2020 Jul 13];155(5):202-4. Available from: https://doi.org/10.1016/j.medcli.2020.05.005 https://doi.org/10.1016/j.medcli.2020.05... , A132525. Luo J, Rizvi H, Preeshagul IR, Egger JV, Hoyos D, Bandlamudi C, et al. COVID-19 in patients with lung cancer. Ann Oncol [Internet]. 2020 [cited 2020 Jul 10];31(10):P1386-96 Available from: https://doi.org/10.1016/j.annonc.2020.06.007 https://doi.org/10.1016/j.annonc.2020.06... , A142626. Robilotti EV, Babady NE, Mead PA, Rolling T, Perez-Johnston R, Bernardes M, et al. Determinants of COVID-19 disease severity in patients with cancer. Nat Med [Internet]. 2020 [cited 2020 Jul 12];26:1218-23. Available from: https://doi.org/10.1038/s41591-020-0979-0 https://doi.org/10.1038/s41591-020-0979-... , A152727. 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Myalgia	A21414. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak. Cancer Discov [Internet]. 2020 [cited 2020 Jul 10];10(6):783-91. Available from: https://doi.org/10.1158/2159-8290.CD-20-0422 https://doi.org/10.1158/2159-8290.CD-20-... , A31515. Garassino MC, Whisenant JG, Huang L-C, Trama A, Torri V, Agustoni F, et al. COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 11];21(7):914-22. Available from: https://doi.org/10.1016/S1470-2045(20)30314-4 https://doi.org/10.1016/S1470-2045(20)30... , A102222. He W, Chen L, Chen L, Yuan G, Fang Y, Chen W, et al. COVID-19 in persons with haematological cancers. Leukemia [Internet]. 2020 [cited 2020 Jul 13];34(6):1637-45. Available from: https://doi.org/10.1038/s41375-020-0836-7 https://doi.org/10.1038/s41375-020-0836-... , A112323. Álvarez LMA, Revuelta RJ, Portero OB, Méndez PC, Montero SG, Alfonso LA. Mortalidad por covid-19 en pacientes con cáncer en un hospital de Madrid durante las primeras 3 semanas de epidemia. Med Clin [Internet]. 2020 [cited 2020 Jul 13];155(5):202-4. Available from: https://doi.org/10.1016/j.medcli.2020.05.005 https://doi.org/10.1016/j.medcli.2020.05... , A152727. Rogado J, Pangua C, Serrano-Montero G, Obispo B, Marino AM, Pérez-Pérez M, et al. Covid-19 and lung cancer: A greater fatality rate? Lung Cancer [Internet]. 2020 [cited 2020 Jul 12];146:19-22. Available from: https://doi.org/10.1016/j.lungcan.2020.05.034 https://doi.org/10.1016/j.lungcan.2020.0... , A162828. Hang H, Wang L, Chen Y, Wu Q, Chen G, Shen X, et al. Outcomes of novel coronavirus disease 2019 (COVID-19) infection in 107 patients with cancer from Wuhan, China. Cancer [Internet]. 2020 [cited 2020 Jul 12];126(17):4023-31. Available from: https://doi.org/10.1002/cncr.33042 https://doi.org/10.1002/cncr.33042... , A172929. Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X. Clinical characteristics and outcomes of cancer patients with COVID-19. J Med Virol [Internet]. 2020 [cited 2020 Jul 12];92(10):2067-73. Available from: https://doi.org/10.1002/jmv.25972 https://doi.org/10.1002/jmv.25972... , A213333. Pinato DJ, Lee AJX, Biello F, Seguí E, Aguilar-Company J, Carbó A, et al. Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe. Cancers [Internet]. 2020 [cited 2020 Jul 13];12(7):1841. Available from: https://doi.org/10.3390/cancers12071841 https://doi.org/10.3390/cancers12071841... , A223434. Rogado J, Obispo B, Pangua C, Serrano-Montero G, Martín Marino A, Pérez-Pérez M, et al. Covid-19 transmission, outcome and associated risk factors in cancer patients at the first month of the pandemic in a Spanish hospital in Madrid. Clin Transl Oncol [Internet]. 2020 [cited 2020 Jul 13];22:2364-68. Available from: https://doi.org/10.1007/s12094-020-02381-z https://doi.org/10.1007/s12094-020-02381... , A253737. Zhang H-Y, Wang L-W, Chen Y-Y, Shen X-K, Wang Q, Yan Y-Q, et al. A multicentre study of 2019 novel Coronavirus disease outcomes of cancer patients in Wuhan, China. medRxiv [Internet]. 2020 [cited 2020 Jul 09];2020.03.21.20037127. Available from: https://doi.org/10.1101/2020.03.21.20037127 https://doi.org/10.1101/2020.03.21.20037...	10 (40)
Nausea and vomiting	A21414. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak. Cancer Discov [Internet]. 2020 [cited 2020 Jul 10];10(6):783-91. Available from: https://doi.org/10.1158/2159-8290.CD-20-0422 https://doi.org/10.1158/2159-8290.CD-20-... , A41616. Lee LYW, Cazier JB, Starkey T, Turnbull CD, Kerr R, Middleton G. COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study. Lancet [Internet]. 2020 [cited 2020 Jul 11];395(10241):1919-26. Available from: https://doi.org/10.1016/S0140-6736(20)31173-9 https://doi.org/10.1016/S0140-6736(20)31... , A61818. Tian J, Yuan X, Xiao J, Zhong Q, Yang C, Liu B, et al. Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):893-903. Available from: https://doi.org/10.1016/S1470-2045(20)30309-0 https://doi.org/10.1016/S1470-2045(20)30... , A71919. Yang K, Sheng Y, Huang C, Jin Y, Xiong N, Jiang K, et al. Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):904-13. Available from: https://doi.org/10.1016/S1470-2045(20)30310-7 https://doi.org/10.1016/S1470-2045(20)30... , A132525. Luo J, Rizvi H, Preeshagul IR, Egger JV, Hoyos D, Bandlamudi C, et al. COVID-19 in patients with lung cancer. Ann Oncol [Internet]. 2020 [cited 2020 Jul 10];31(10):P1386-96 Available from: https://doi.org/10.1016/j.annonc.2020.06.007 https://doi.org/10.1016/j.annonc.2020.06... , A213333. Pinato DJ, Lee AJX, Biello F, Seguí E, Aguilar-Company J, Carbó A, et al. Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe. Cancers [Internet]. 2020 [cited 2020 Jul 13];12(7):1841. Available from: https://doi.org/10.3390/cancers12071841 https://doi.org/10.3390/cancers12071841... , A253737. Zhang H-Y, Wang L-W, Chen Y-Y, Shen X-K, Wang Q, Yan Y-Q, et al. A multicentre study of 2019 novel Coronavirus disease outcomes of cancer patients in Wuhan, China. medRxiv [Internet]. 2020 [cited 2020 Jul 09];2020.03.21.20037127. Available from: https://doi.org/10.1101/2020.03.21.20037127 https://doi.org/10.1101/2020.03.21.20037...	7 (28)
Headache	A21414. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak. Cancer Discov [Internet]. 2020 [cited 2020 Jul 10];10(6):783-91. Available from: https://doi.org/10.1158/2159-8290.CD-20-0422 https://doi.org/10.1158/2159-8290.CD-20-... , A31515. Garassino MC, Whisenant JG, Huang L-C, Trama A, Torri V, Agustoni F, et al. COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 11];21(7):914-22. Available from: https://doi.org/10.1016/S1470-2045(20)30314-4 https://doi.org/10.1016/S1470-2045(20)30... , A61818. Tian J, Yuan X, Xiao J, Zhong Q, Yang C, Liu B, et al. Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):893-903. Available from: https://doi.org/10.1016/S1470-2045(20)30309-0 https://doi.org/10.1016/S1470-2045(20)30... , A102222. He W, Chen L, Chen L, Yuan G, Fang Y, Chen W, et al. COVID-19 in persons with haematological cancers. Leukemia [Internet]. 2020 [cited 2020 Jul 13];34(6):1637-45. Available from: https://doi.org/10.1038/s41375-020-0836-7 https://doi.org/10.1038/s41375-020-0836-... , A172929. Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X. Clinical characteristics and outcomes of cancer patients with COVID-19. J Med Virol [Internet]. 2020 [cited 2020 Jul 12];92(10):2067-73. Available from: https://doi.org/10.1002/jmv.25972 https://doi.org/10.1002/jmv.25972... , A183030. Basse C, Diakite S, Servois V, Frelaut M, Noret A, Bellesoeur A, et al. Characteristics and outcome of SARS-CoV-2 infection in cancer patients. medRxiv [Internet]. 2020 [cited 2020 Jul 12];2020.05.14.20101576. Available from: https://doi.org/10.1101/2020.05.14.20101576 https://doi.org/10.1101/2020.05.14.20101... , A213333. Pinato DJ, Lee AJX, Biello F, Seguí E, Aguilar-Company J, Carbó A, et al. Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe. Cancers [Internet]. 2020 [cited 2020 Jul 13];12(7):1841. Available from: https://doi.org/10.3390/cancers12071841 https://doi.org/10.3390/cancers12071841...	7 (28)
Anosmia and ageusia	A11313. Assaad S, Avrillon V, Fournier M-L, Mastroianni B, Russias B, Swalduz A, et al. High mortality rate in cancer patients with symptoms of COVID-19 with or without detectable SARS-COV-2 on RT-PCR. Eur J Cancer [Internet]. 2020 [cited 2020 Jul 01];135:251-9. Available from: https://doi.org/10.1016/j.ejca.2020.05.028 https://doi.org/10.1016/j.ejca.2020.05.0... , A31515. Garassino MC, Whisenant JG, Huang L-C, Trama A, Torri V, Agustoni F, et al. COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 11];21(7):914-22. Available from: https://doi.org/10.1016/S1470-2045(20)30314-4 https://doi.org/10.1016/S1470-2045(20)30... , A41616. Lee LYW, Cazier JB, Starkey T, Turnbull CD, Kerr R, Middleton G. COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study. Lancet [Internet]. 2020 [cited 2020 Jul 11];395(10241):1919-26. Available from: https://doi.org/10.1016/S0140-6736(20)31173-9 https://doi.org/10.1016/S0140-6736(20)31... , A183030. Basse C, Diakite S, Servois V, Frelaut M, Noret A, Bellesoeur A, et al. Characteristics and outcome of SARS-CoV-2 infection in cancer patients. medRxiv [Internet]. 2020 [cited 2020 Jul 12];2020.05.14.20101576. Available from: https://doi.org/10.1101/2020.05.14.20101576 https://doi.org/10.1101/2020.05.14.20101... , A213333. Pinato DJ, Lee AJX, Biello F, Seguí E, Aguilar-Company J, Carbó A, et al. Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe. Cancers [Internet]. 2020 [cited 2020 Jul 13];12(7):1841. Available from: https://doi.org/10.3390/cancers12071841 https://doi.org/10.3390/cancers12071841...	5 (20)
Treatment
Antivirals	A21414. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak. Cancer Discov [Internet]. 2020 [cited 2020 Jul 10];10(6):783-91. Available from: https://doi.org/10.1158/2159-8290.CD-20-0422 https://doi.org/10.1158/2159-8290.CD-20-... , A61818. Tian J, Yuan X, Xiao J, Zhong Q, Yang C, Liu B, et al. Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):893-903. Available from: https://doi.org/10.1016/S1470-2045(20)30309-0 https://doi.org/10.1016/S1470-2045(20)30... , A71919. Yang K, Sheng Y, Huang C, Jin Y, Xiong N, Jiang K, et al. Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):904-13. Available from: https://doi.org/10.1016/S1470-2045(20)30310-7 https://doi.org/10.1016/S1470-2045(20)30... , A82020. Yarza R, Bover M, Paredes D, López-López F, Jara-Casas D, Castelo-Loureiro A, et al. SARS-CoV-2 infection in cancer patients undergoing active treatment: analysis of clinical features and predictive factors for severe respiratory failure and death. Eur J Cancer [Internet]. 2020 [cited 2020 Jul 12];135:242-50. Available from: https://doi.org/10.1016/j.ejca.2020.06.001 https://doi.org/10.1016/j.ejca.2020.06.0... , A92121. Zhang L, Zhu F, Xie L, Wang C, Wang J, Chen R, et al. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Ann Oncol [Internet]. 2020 [cited 2020 Jul 13];31(7):894-901. Available from: https://doi.org/10.1016/j.annonc.2020.03.296 https://doi.org/10.1016/j.annonc.2020.03... , A102222. He W, Chen L, Chen L, Yuan G, Fang Y, Chen W, et al. COVID-19 in persons with haematological cancers. Leukemia [Internet]. 2020 [cited 2020 Jul 13];34(6):1637-45. Available from: https://doi.org/10.1038/s41375-020-0836-7 https://doi.org/10.1038/s41375-020-0836-... , A112323. Álvarez LMA, Revuelta RJ, Portero OB, Méndez PC, Montero SG, Alfonso LA. Mortalidad por covid-19 en pacientes con cáncer en un hospital de Madrid durante las primeras 3 semanas de epidemia. Med Clin [Internet]. 2020 [cited 2020 Jul 13];155(5):202-4. Available from: https://doi.org/10.1016/j.medcli.2020.05.005 https://doi.org/10.1016/j.medcli.2020.05... , A152727. Rogado J, Pangua C, Serrano-Montero G, Obispo B, Marino AM, Pérez-Pérez M, et al. Covid-19 and lung cancer: A greater fatality rate? Lung Cancer [Internet]. 2020 [cited 2020 Jul 12];146:19-22. Available from: https://doi.org/10.1016/j.lungcan.2020.05.034 https://doi.org/10.1016/j.lungcan.2020.0... , A162828. Hang H, Wang L, Chen Y, Wu Q, Chen G, Shen X, et al. Outcomes of novel coronavirus disease 2019 (COVID-19) infection in 107 patients with cancer from Wuhan, China. Cancer [Internet]. 2020 [cited 2020 Jul 12];126(17):4023-31. Available from: https://doi.org/10.1002/cncr.33042 https://doi.org/10.1002/cncr.33042... , A172929. Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X. Clinical characteristics and outcomes of cancer patients with COVID-19. J Med Virol [Internet]. 2020 [cited 2020 Jul 12];92(10):2067-73. Available from: https://doi.org/10.1002/jmv.25972 https://doi.org/10.1002/jmv.25972... , A183030. Basse C, Diakite S, Servois V, Frelaut M, Noret A, Bellesoeur A, et al. Characteristics and outcome of SARS-CoV-2 infection in cancer patients. medRxiv [Internet]. 2020 [cited 2020 Jul 12];2020.05.14.20101576. Available from: https://doi.org/10.1101/2020.05.14.20101576 https://doi.org/10.1101/2020.05.14.20101... , A213333. Pinato DJ, Lee AJX, Biello F, Seguí E, Aguilar-Company J, Carbó A, et al. Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe. Cancers [Internet]. 2020 [cited 2020 Jul 13];12(7):1841. Available from: https://doi.org/10.3390/cancers12071841 https://doi.org/10.3390/cancers12071841... , A223434. Rogado J, Obispo B, Pangua C, Serrano-Montero G, Martín Marino A, Pérez-Pérez M, et al. Covid-19 transmission, outcome and associated risk factors in cancer patients at the first month of the pandemic in a Spanish hospital in Madrid. Clin Transl Oncol [Internet]. 2020 [cited 2020 Jul 13];22:2364-68. Available from: https://doi.org/10.1007/s12094-020-02381-z https://doi.org/10.1007/s12094-020-02381... , A233535. Stroppa EM, Toscani I, Citterio C, Anselmi E, Zaffignani E, Codeluppi M, et al. Coronavirus disease-2019 in cancer patients. A report of the first 25 cancer patients in a western country (Italy). 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Antibiotics	A21414. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak. Cancer Discov [Internet]. 2020 [cited 2020 Jul 10];10(6):783-91. Available from: https://doi.org/10.1158/2159-8290.CD-20-0422 https://doi.org/10.1158/2159-8290.CD-20-... , A61818. Tian J, Yuan X, Xiao J, Zhong Q, Yang C, Liu B, et al. Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):893-903. Available from: https://doi.org/10.1016/S1470-2045(20)30309-0 https://doi.org/10.1016/S1470-2045(20)30... , A71919. Yang K, Sheng Y, Huang C, Jin Y, Xiong N, Jiang K, et al. Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study. 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He W, Chen L, Chen L, Yuan G, Fang Y, Chen W, et al. COVID-19 in persons with haematological cancers. Leukemia [Internet]. 2020 [cited 2020 Jul 13];34(6):1637-45. Available from: https://doi.org/10.1038/s41375-020-0836-7 https://doi.org/10.1038/s41375-020-0836-... , A112323. Álvarez LMA, Revuelta RJ, Portero OB, Méndez PC, Montero SG, Alfonso LA. Mortalidad por covid-19 en pacientes con cáncer en un hospital de Madrid durante las primeras 3 semanas de epidemia. Med Clin [Internet]. 2020 [cited 2020 Jul 13];155(5):202-4. Available from: https://doi.org/10.1016/j.medcli.2020.05.005 https://doi.org/10.1016/j.medcli.2020.05... , A122424. Kuderer NM, Choueiri TK, Shah DP, Shyr Y, Rubinstein SM, Rivera DR, et al. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study. Lancet [Internet]. 2020 [cited 2020 Jul 04];395(10241):1907-18. Available from: https://doi.org/10.1016/S0140-6736(20)31187-9 https://doi.org/10.1016/S0140-6736(20)31... , A152727. Rogado J, Pangua C, Serrano-Montero G, Obispo B, Marino AM, Pérez-Pérez M, et al. Covid-19 and lung cancer: A greater fatality rate? Lung Cancer [Internet]. 2020 [cited 2020 Jul 12];146:19-22. Available from: https://doi.org/10.1016/j.lungcan.2020.05.034 https://doi.org/10.1016/j.lungcan.2020.0... , A162828. Hang H, Wang L, Chen Y, Wu Q, Chen G, Shen X, et al. Outcomes of novel coronavirus disease 2019 (COVID-19) infection in 107 patients with cancer from Wuhan, China. Cancer [Internet]. 2020 [cited 2020 Jul 12];126(17):4023-31. Available from: https://doi.org/10.1002/cncr.33042 https://doi.org/10.1002/cncr.33042... , A172929. Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X. Clinical characteristics and outcomes of cancer patients with COVID-19. J Med Virol [Internet]. 2020 [cited 2020 Jul 12];92(10):2067-73. Available from: https://doi.org/10.1002/jmv.25972 https://doi.org/10.1002/jmv.25972... , A183030. Basse C, Diakite S, Servois V, Frelaut M, Noret A, Bellesoeur A, et al. Characteristics and outcome of SARS-CoV-2 infection in cancer patients. medRxiv [Internet]. 2020 [cited 2020 Jul 12];2020.05.14.20101576. Available from: https://doi.org/10.1101/2020.05.14.20101576 https://doi.org/10.1101/2020.05.14.20101... , A213333. Pinato DJ, Lee AJX, Biello F, Seguí E, Aguilar-Company J, Carbó A, et al. Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe. Cancers [Internet]. 2020 [cited 2020 Jul 13];12(7):1841. Available from: https://doi.org/10.3390/cancers12071841 https://doi.org/10.3390/cancers12071841... , A223434. Rogado J, Obispo B, Pangua C, Serrano-Montero G, Martín Marino A, Pérez-Pérez M, et al. Covid-19 transmission, outcome and associated risk factors in cancer patients at the first month of the pandemic in a Spanish hospital in Madrid. Clin Transl Oncol [Internet]. 2020 [cited 2020 Jul 13];22:2364-68. 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IMV \|\|	A31515. Garassino MC, Whisenant JG, Huang L-C, Trama A, Torri V, Agustoni F, et al. COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 11];21(7):914-22. Available from: https://doi.org/10.1016/S1470-2045(20)30314-4 https://doi.org/10.1016/S1470-2045(20)30... , A51717. Mehta V, Goel S, Kabarriti R, Cole D, Goldfinger M, Acuna-Villaorduna A, et al. Case fatality rate of cancer patients with COVID-19 in a New York hospital system. Cancer Discov [Internet]. 2020 [cited 2020 Jul 09];10:93541. Available from: doi: Available from: doi: https://doi.org/10.1158/2159-8290.cd-20-0516 https://doi.org/10.1158/2159-8290.cd-20-... , A61616. Lee LYW, Cazier JB, Starkey T, Turnbull CD, Kerr R, Middleton G. COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study. Lancet [Internet]. 2020 [cited 2020 Jul 11];395(10241):1919-26. Available from: https://doi.org/10.1016/S0140-6736(20)31173-9 https://doi.org/10.1016/S0140-6736(20)31... , A71818. Tian J, Yuan X, Xiao J, Zhong Q, Yang C, Liu B, et al. Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):893-903. Available from: https://doi.org/10.1016/S1470-2045(20)30309-0 https://doi.org/10.1016/S1470-2045(20)30... , A92121. Zhang L, Zhu F, Xie L, Wang C, Wang J, Chen R, et al. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Ann Oncol [Internet]. 2020 [cited 2020 Jul 13];31(7):894-901. Available from: https://doi.org/10.1016/j.annonc.2020.03.296 https://doi.org/10.1016/j.annonc.2020.03... , A102222. He W, Chen L, Chen L, Yuan G, Fang Y, Chen W, et al. COVID-19 in persons with haematological cancers. Leukemia [Internet]. 2020 [cited 2020 Jul 13];34(6):1637-45. Available from: https://doi.org/10.1038/s41375-020-0836-7 https://doi.org/10.1038/s41375-020-0836-... , A122424. Kuderer NM, Choueiri TK, Shah DP, Shyr Y, Rubinstein SM, Rivera DR, et al. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study. Lancet [Internet]. 2020 [cited 2020 Jul 04];395(10241):1907-18. Available from: https://doi.org/10.1016/S0140-6736(20)31187-9 https://doi.org/10.1016/S0140-6736(20)31... , A132525. Luo J, Rizvi H, Preeshagul IR, Egger JV, Hoyos D, Bandlamudi C, et al. COVID-19 in patients with lung cancer. Ann Oncol [Internet]. 2020 [cited 2020 Jul 10];31(10):P1386-96 Available from: https://doi.org/10.1016/j.annonc.2020.06.007 https://doi.org/10.1016/j.annonc.2020.06... , A142626. Robilotti EV, Babady NE, Mead PA, Rolling T, Perez-Johnston R, Bernardes M, et al. Determinants of COVID-19 disease severity in patients with cancer. Nat Med [Internet]. 2020 [cited 2020 Jul 12];26:1218-23. Available from: https://doi.org/10.1038/s41591-020-0979-0 https://doi.org/10.1038/s41591-020-0979-... , A162828. Hang H, Wang L, Chen Y, Wu Q, Chen G, Shen X, et al. Outcomes of novel coronavirus disease 2019 (COVID-19) infection in 107 patients with cancer from Wuhan, China. Cancer [Internet]. 2020 [cited 2020 Jul 12];126(17):4023-31. Available from: https://doi.org/10.1002/cncr.33042 https://doi.org/10.1002/cncr.33042... , A213333. Pinato DJ, Lee AJX, Biello F, Seguí E, Aguilar-Company J, Carbó A, et al. Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe. Cancers [Internet]. 2020 [cited 2020 Jul 13];12(7):1841. Available from: https://doi.org/10.3390/cancers12071841 https://doi.org/10.3390/cancers12071841... , A243636. Wang J, Song Q, Chen Y, Wang Z, Chu Q, Gong H, et al. Systematic investigations of COVID-19 in 283 cancer patients [Internet]. medRxiv [Internet]. 2020 [cited 2020 Jul 09];2020.04.28.20083246. Available from: https://doi.org/10.1101/2020.04.28.20083246 https://doi.org/10.1101/2020.04.28.20083... , A253737. Zhang H-Y, Wang L-W, Chen Y-Y, Shen X-K, Wang Q, Yan Y-Q, et al. A multicentre study of 2019 novel Coronavirus disease outcomes of cancer patients in Wuhan, China. medRxiv [Internet]. 2020 [cited 2020 Jul 09];2020.03.21.20037127. Available from: https://doi.org/10.1101/2020.03.21.20037127 https://doi.org/10.1101/2020.03.21.20037...	13 (52)
Oxygen therapy	A21414. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak. Cancer Discov [Internet]. 2020 [cited 2020 Jul 10];10(6):783-91. Available from: https://doi.org/10.1158/2159-8290.CD-20-0422 https://doi.org/10.1158/2159-8290.CD-20-... , A41616. Lee LYW, Cazier JB, Starkey T, Turnbull CD, Kerr R, Middleton G. COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study. Lancet [Internet]. 2020 [cited 2020 Jul 11];395(10241):1919-26. Available from: https://doi.org/10.1016/S0140-6736(20)31173-9 https://doi.org/10.1016/S0140-6736(20)31... , A61818. Tian J, Yuan X, Xiao J, Zhong Q, Yang C, Liu B, et al. Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):893-903. Available from: https://doi.org/10.1016/S1470-2045(20)30309-0 https://doi.org/10.1016/S1470-2045(20)30... , A71919. Yang K, Sheng Y, Huang C, Jin Y, Xiong N, Jiang K, et al. Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):904-13. Available from: https://doi.org/10.1016/S1470-2045(20)30310-7 https://doi.org/10.1016/S1470-2045(20)30... , A92121. Zhang L, Zhu F, Xie L, Wang C, Wang J, Chen R, et al. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Ann Oncol [Internet]. 2020 [cited 2020 Jul 13];31(7):894-901. Available from: https://doi.org/10.1016/j.annonc.2020.03.296 https://doi.org/10.1016/j.annonc.2020.03... , A102222. He W, Chen L, Chen L, Yuan G, Fang Y, Chen W, et al. COVID-19 in persons with haematological cancers. Leukemia [Internet]. 2020 [cited 2020 Jul 13];34(6):1637-45. Available from: https://doi.org/10.1038/s41375-020-0836-7 https://doi.org/10.1038/s41375-020-0836-... , A132525. Luo J, Rizvi H, Preeshagul IR, Egger JV, Hoyos D, Bandlamudi C, et al. COVID-19 in patients with lung cancer. Ann Oncol [Internet]. 2020 [cited 2020 Jul 10];31(10):P1386-96 Available from: https://doi.org/10.1016/j.annonc.2020.06.007 https://doi.org/10.1016/j.annonc.2020.06... , A142626. Robilotti EV, Babady NE, Mead PA, Rolling T, Perez-Johnston R, Bernardes M, et al. Determinants of COVID-19 disease severity in patients with cancer. Nat Med [Internet]. 2020 [cited 2020 Jul 12];26:1218-23. Available from: https://doi.org/10.1038/s41591-020-0979-0 https://doi.org/10.1038/s41591-020-0979-... , A172929. Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X. Clinical characteristics and outcomes of cancer patients with COVID-19. J Med Virol [Internet]. 2020 [cited 2020 Jul 12];92(10):2067-73. Available from: https://doi.org/10.1002/jmv.25972 https://doi.org/10.1002/jmv.25972... , A213333. Pinato DJ, Lee AJX, Biello F, Seguí E, Aguilar-Company J, Carbó A, et al. Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe. Cancers [Internet]. 2020 [cited 2020 Jul 13];12(7):1841. Available from: https://doi.org/10.3390/cancers12071841 https://doi.org/10.3390/cancers12071841... , A233535. Stroppa EM, Toscani I, Citterio C, Anselmi E, Zaffignani E, Codeluppi M, et al. Coronavirus disease-2019 in cancer patients. A report of the first 25 cancer patients in a western country (Italy). Future Oncol [Internet]. 2020 [cited 2020 Jul 09];16(20):1425-32. Available from: https://doi.org/10.2217/fon-2020-0369 https://doi.org/10.2217/fon-2020-0369... , A253737. Zhang H-Y, Wang L-W, Chen Y-Y, Shen X-K, Wang Q, Yan Y-Q, et al. A multicentre study of 2019 novel Coronavirus disease outcomes of cancer patients in Wuhan, China. medRxiv [Internet]. 2020 [cited 2020 Jul 09];2020.03.21.20037127. Available from: https://doi.org/10.1101/2020.03.21.20037127 https://doi.org/10.1101/2020.03.21.20037...	12 (48)
Non-Invasive	A21414. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak. Cancer Discov [Internet]. 2020 [cited 2020 Jul 10];10(6):783-91. Available from: https://doi.org/10.1158/2159-8290.CD-20-0422 https://doi.org/10.1158/2159-8290.CD-20-... , A31515. Garassino MC, Whisenant JG, Huang L-C, Trama A, Torri V, Agustoni F, et al. COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 11];21(7):914-22. Available from: https://doi.org/10.1016/S1470-2045(20)30314-4 https://doi.org/10.1016/S1470-2045(20)30... , A71919. Yang K, Sheng Y, Huang C, Jin Y, Xiong N, Jiang K, et al. Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):904-13. Available from: https://doi.org/10.1016/S1470-2045(20)30310-7 https://doi.org/10.1016/S1470-2045(20)30... , A92121. Zhang L, Zhu F, Xie L, Wang C, Wang J, Chen R, et al. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Ann Oncol [Internet]. 2020 [cited 2020 Jul 13];31(7):894-901. Available from: https://doi.org/10.1016/j.annonc.2020.03.296 https://doi.org/10.1016/j.annonc.2020.03... , A102222. He W, Chen L, Chen L, Yuan G, Fang Y, Chen W, et al. COVID-19 in persons with haematological cancers. Leukemia [Internet]. 2020 [cited 2020 Jul 13];34(6):1637-45. Available from: https://doi.org/10.1038/s41375-020-0836-7 https://doi.org/10.1038/s41375-020-0836-... , A172929. Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X. Clinical characteristics and outcomes of cancer patients with COVID-19. J Med Virol [Internet]. 2020 [cited 2020 Jul 12];92(10):2067-73. Available from: https://doi.org/10.1002/jmv.25972 https://doi.org/10.1002/jmv.25972... , A183030. Basse C, Diakite S, Servois V, Frelaut M, Noret A, Bellesoeur A, et al. Characteristics and outcome of SARS-CoV-2 infection in cancer patients. medRxiv [Internet]. 2020 [cited 2020 Jul 12];2020.05.14.20101576. Available from: https://doi.org/10.1101/2020.05.14.20101576 https://doi.org/10.1101/2020.05.14.20101... , A213333. Pinato DJ, Lee AJX, Biello F, Seguí E, Aguilar-Company J, Carbó A, et al. Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe. Cancers [Internet]. 2020 [cited 2020 Jul 13];12(7):1841. Available from: https://doi.org/10.3390/cancers12071841 https://doi.org/10.3390/cancers12071841... , A223434. Rogado J, Obispo B, Pangua C, Serrano-Montero G, Martín Marino A, Pérez-Pérez M, et al. Covid-19 transmission, outcome and associated risk factors in cancer patients at the first month of the pandemic in a Spanish hospital in Madrid. Clin Transl Oncol [Internet]. 2020 [cited 2020 Jul 13];22:2364-68. Available from: https://doi.org/10.1007/s12094-020-02381-z https://doi.org/10.1007/s12094-020-02381... , A253737. Zhang H-Y, Wang L-W, Chen Y-Y, Shen X-K, Wang Q, Yan Y-Q, et al. A multicentre study of 2019 novel Coronavirus disease outcomes of cancer patients in Wuhan, China. medRxiv [Internet]. 2020 [cited 2020 Jul 09];2020.03.21.20037127. Available from: https://doi.org/10.1101/2020.03.21.20037127 https://doi.org/10.1101/2020.03.21.20037...	10 (40)
Glucocorticoids	A82020. Yarza R, Bover M, Paredes D, López-López F, Jara-Casas D, Castelo-Loureiro A, et al. SARS-CoV-2 infection in cancer patients undergoing active treatment: analysis of clinical features and predictive factors for severe respiratory failure and death. Eur J Cancer [Internet]. 2020 [cited 2020 Jul 12];135:242-50. Available from: https://doi.org/10.1016/j.ejca.2020.06.001 https://doi.org/10.1016/j.ejca.2020.06.0... , A112323. Álvarez LMA, Revuelta RJ, Portero OB, Méndez PC, Montero SG, Alfonso LA. Mortalidad por covid-19 en pacientes con cáncer en un hospital de Madrid durante las primeras 3 semanas de epidemia. Med Clin [Internet]. 2020 [cited 2020 Jul 13];155(5):202-4. Available from: https://doi.org/10.1016/j.medcli.2020.05.005 https://doi.org/10.1016/j.medcli.2020.05... , A122424. Kuderer NM, Choueiri TK, Shah DP, Shyr Y, Rubinstein SM, Rivera DR, et al. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study. Lancet [Internet]. 2020 [cited 2020 Jul 04];395(10241):1907-18. Available from: https://doi.org/10.1016/S0140-6736(20)31187-9 https://doi.org/10.1016/S0140-6736(20)31... , A132525. Luo J, Rizvi H, Preeshagul IR, Egger JV, Hoyos D, Bandlamudi C, et al. COVID-19 in patients with lung cancer. Ann Oncol [Internet]. 2020 [cited 2020 Jul 10];31(10):P1386-96 Available from: https://doi.org/10.1016/j.annonc.2020.06.007 https://doi.org/10.1016/j.annonc.2020.06... , A152727. Rogado J, Pangua C, Serrano-Montero G, Obispo B, Marino AM, Pérez-Pérez M, et al. Covid-19 and lung cancer: A greater fatality rate? Lung Cancer [Internet]. 2020 [cited 2020 Jul 12];146:19-22. Available from: https://doi.org/10.1016/j.lungcan.2020.05.034 https://doi.org/10.1016/j.lungcan.2020.0... , A162828. Hang H, Wang L, Chen Y, Wu Q, Chen G, Shen X, et al. Outcomes of novel coronavirus disease 2019 (COVID-19) infection in 107 patients with cancer from Wuhan, China. Cancer [Internet]. 2020 [cited 2020 Jul 12];126(17):4023-31. Available from: https://doi.org/10.1002/cncr.33042 https://doi.org/10.1002/cncr.33042... , A213333. Pinato DJ, Lee AJX, Biello F, Seguí E, Aguilar-Company J, Carbó A, et al. Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe. Cancers [Internet]. 2020 [cited 2020 Jul 13];12(7):1841. Available from: https://doi.org/10.3390/cancers12071841 https://doi.org/10.3390/cancers12071841... , A223434. Rogado J, Obispo B, Pangua C, Serrano-Montero G, Martín Marino A, Pérez-Pérez M, et al. Covid-19 transmission, outcome and associated risk factors in cancer patients at the first month of the pandemic in a Spanish hospital in Madrid. Clin Transl Oncol [Internet]. 2020 [cited 2020 Jul 13];22:2364-68. Available from: https://doi.org/10.1007/s12094-020-02381-z https://doi.org/10.1007/s12094-020-02381... , A233535. Stroppa EM, Toscani I, Citterio C, Anselmi E, Zaffignani E, Codeluppi M, et al. Coronavirus disease-2019 in cancer patients. A report of the first 25 cancer patients in a western country (Italy). Future Oncol [Internet]. 2020 [cited 2020 Jul 09];16(20):1425-32. Available from: https://doi.org/10.2217/fon-2020-0369 https://doi.org/10.2217/fon-2020-0369...	9 (36)
Chloroquines	A61818. Tian J, Yuan X, Xiao J, Zhong Q, Yang C, Liu B, et al. Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):893-903. Available from: https://doi.org/10.1016/S1470-2045(20)30309-0 https://doi.org/10.1016/S1470-2045(20)30... , A71919. Yang K, Sheng Y, Huang C, Jin Y, Xiong N, Jiang K, et al. Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):904-13. Available from: https://doi.org/10.1016/S1470-2045(20)30310-7 https://doi.org/10.1016/S1470-2045(20)30... , A162828. Hang H, Wang L, Chen Y, Wu Q, Chen G, Shen X, et al. Outcomes of novel coronavirus disease 2019 (COVID-19) infection in 107 patients with cancer from Wuhan, China. Cancer [Internet]. 2020 [cited 2020 Jul 12];126(17):4023-31. Available from: https://doi.org/10.1002/cncr.33042 https://doi.org/10.1002/cncr.33042... , A172929. Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X. Clinical characteristics and outcomes of cancer patients with COVID-19. J Med Virol [Internet]. 2020 [cited 2020 Jul 12];92(10):2067-73. Available from: https://doi.org/10.1002/jmv.25972 https://doi.org/10.1002/jmv.25972... , A253737. Zhang H-Y, Wang L-W, Chen Y-Y, Shen X-K, Wang Q, Yan Y-Q, et al. A multicentre study of 2019 novel Coronavirus disease outcomes of cancer patients in Wuhan, China. medRxiv [Internet]. 2020 [cited 2020 Jul 09];2020.03.21.20037127. Available from: https://doi.org/10.1101/2020.03.21.20037127 https://doi.org/10.1101/2020.03.21.20037...	5 (20)
Mortality rate
Between 11 - 20 %	A21414. Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak. Cancer Discov [Internet]. 2020 [cited 2020 Jul 10];10(6):783-91. Available from: https://doi.org/10.1158/2159-8290.CD-20-0422 https://doi.org/10.1158/2159-8290.CD-20-... , A71919. Yang K, Sheng Y, Huang C, Jin Y, Xiong N, Jiang K, et al. Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):904-13. Available from: https://doi.org/10.1016/S1470-2045(20)30310-7 https://doi.org/10.1016/S1470-2045(20)30... , A122424. Kuderer NM, Choueiri TK, Shah DP, Shyr Y, Rubinstein SM, Rivera DR, et al. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study. Lancet [Internet]. 2020 [cited 2020 Jul 04];395(10241):1907-18. Available from: https://doi.org/10.1016/S0140-6736(20)31187-9 https://doi.org/10.1016/S0140-6736(20)31... , A142626. Robilotti EV, Babady NE, Mead PA, Rolling T, Perez-Johnston R, Bernardes M, et al. Determinants of COVID-19 disease severity in patients with cancer. Nat Med [Internet]. 2020 [cited 2020 Jul 12];26:1218-23. Available from: https://doi.org/10.1038/s41591-020-0979-0 https://doi.org/10.1038/s41591-020-0979-... , A183030. Basse C, Diakite S, Servois V, Frelaut M, Noret A, Bellesoeur A, et al. Characteristics and outcome of SARS-CoV-2 infection in cancer patients. medRxiv [Internet]. 2020 [cited 2020 Jul 12];2020.05.14.20101576. Available from: https://doi.org/10.1101/2020.05.14.20101576 https://doi.org/10.1101/2020.05.14.20101... , A253737. Zhang H-Y, Wang L-W, Chen Y-Y, Shen X-K, Wang Q, Yan Y-Q, et al. A multicentre study of 2019 novel Coronavirus disease outcomes of cancer patients in Wuhan, China. medRxiv [Internet]. 2020 [cited 2020 Jul 09];2020.03.21.20037127. Available from: https://doi.org/10.1101/2020.03.21.20037127 https://doi.org/10.1101/2020.03.21.20037...	6 (24)
Between 21- 30 %	A11313. Assaad S, Avrillon V, Fournier M-L, Mastroianni B, Russias B, Swalduz A, et al. High mortality rate in cancer patients with symptoms of COVID-19 with or without detectable SARS-COV-2 on RT-PCR. Eur J Cancer [Internet]. 2020 [cited 2020 Jul 01];135:251-9. Available from: https://doi.org/10.1016/j.ejca.2020.05.028 https://doi.org/10.1016/j.ejca.2020.05.0... , A41616. Lee LYW, Cazier JB, Starkey T, Turnbull CD, Kerr R, Middleton G. COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study. Lancet [Internet]. 2020 [cited 2020 Jul 11];395(10241):1919-26. Available from: https://doi.org/10.1016/S0140-6736(20)31173-9 https://doi.org/10.1016/S0140-6736(20)31... , A51717. Mehta V, Goel S, Kabarriti R, Cole D, Goldfinger M, Acuna-Villaorduna A, et al. Case fatality rate of cancer patients with COVID-19 in a New York hospital system. Cancer Discov [Internet]. 2020 [cited 2020 Jul 09];10:93541. Available from: doi: Available from: doi: https://doi.org/10.1158/2159-8290.cd-20-0516 https://doi.org/10.1158/2159-8290.cd-20-... , A61818. Tian J, Yuan X, Xiao J, Zhong Q, Yang C, Liu B, et al. Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 12];21(7):893-903. Available from: https://doi.org/10.1016/S1470-2045(20)30309-0 https://doi.org/10.1016/S1470-2045(20)30... , A92121. Zhang L, Zhu F, Xie L, Wang C, Wang J, Chen R, et al. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Ann Oncol [Internet]. 2020 [cited 2020 Jul 13];31(7):894-901. Available from: https://doi.org/10.1016/j.annonc.2020.03.296 https://doi.org/10.1016/j.annonc.2020.03... , A132525. Luo J, Rizvi H, Preeshagul IR, Egger JV, Hoyos D, Bandlamudi C, et al. COVID-19 in patients with lung cancer. Ann Oncol [Internet]. 2020 [cited 2020 Jul 10];31(10):P1386-96 Available from: https://doi.org/10.1016/j.annonc.2020.06.007 https://doi.org/10.1016/j.annonc.2020.06... , A172929. Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X. Clinical characteristics and outcomes of cancer patients with COVID-19. J Med Virol [Internet]. 2020 [cited 2020 Jul 12];92(10):2067-73. Available from: https://doi.org/10.1002/jmv.25972 https://doi.org/10.1002/jmv.25972... , A193131. Fong D, Rauch S, Petter C, Haspinger E, Alber M, Mitterer M. Infection rate and clinical management of cancer patients during the COVID-19 pandemic: experience from a tertiary care hospital in northern Italy. ESMO Open [Internet]. 2020 [cited 2020 Jul 13];5(3):e000810. Available from: https://doi.org/10.1136/esmoopen-2020-000810 https://doi.org/10.1136/esmoopen-2020-00... , A213333. Pinato DJ, Lee AJX, Biello F, Seguí E, Aguilar-Company J, Carbó A, et al. Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe. Cancers [Internet]. 2020 [cited 2020 Jul 13];12(7):1841. Available from: https://doi.org/10.3390/cancers12071841 https://doi.org/10.3390/cancers12071841...	9 (36)
Between 31 - 40%	A31515. Garassino MC, Whisenant JG, Huang L-C, Trama A, Torri V, Agustoni F, et al. COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study. Lancet Oncol [Internet]. 2020 [cited 2020 Jul 11];21(7):914-22. Available from: https://doi.org/10.1016/S1470-2045(20)30314-4 https://doi.org/10.1016/S1470-2045(20)30... , A203232. Nakamura S, Kanemasa Y, Atsuta Y, Fujiwara S, Tanaka M, Fukushima K, et al. Characteristics and outcomes of coronavirus disease 2019 (COVID-19) patients with cancer: a single-center retrospective observational study in Tokyo, Japan. Research Square [Internet]. 2020 [cited 2020 Jul 13] Available from: https://doi.org/10.21203/rs.3.rs-39157/v1 https://doi.org/10.21203/rs.3.rs-39157/v... , A243636. Wang J, Song Q, Chen Y, Wang Z, Chu Q, Gong H, et al. Systematic investigations of COVID-19 in 283 cancer patients [Internet]. medRxiv [Internet]. 2020 [cited 2020 Jul 09];2020.04.28.20083246. Available from: https://doi.org/10.1101/2020.04.28.20083246 https://doi.org/10.1101/2020.04.28.20083...	3 (12)
Between 41% - 50%	A112323. Álvarez LMA, Revuelta RJ, Portero OB, Méndez PC, Montero SG, Alfonso LA. Mortalidad por covid-19 en pacientes con cáncer en un hospital de Madrid durante las primeras 3 semanas de epidemia. Med Clin [Internet]. 2020 [cited 2020 Jul 13];155(5):202-4. Available from: https://doi.org/10.1016/j.medcli.2020.05.005 https://doi.org/10.1016/j.medcli.2020.05... , A223434. Rogado J, Obispo B, Pangua C, Serrano-Montero G, Martín Marino A, Pérez-Pérez M, et al. Covid-19 transmission, outcome and associated risk factors in cancer patients at the first month of the pandemic in a Spanish hospital in Madrid. Clin Transl Oncol [Internet]. 2020 [cited 2020 Jul 13];22:2364-68. Available from: https://doi.org/10.1007/s12094-020-02381-z https://doi.org/10.1007/s12094-020-02381...	2 (8)
Higher than 50%	A102222. He W, Chen L, Chen L, Yuan G, Fang Y, Chen W, et al. COVID-19 in persons with haematological cancers. Leukemia [Internet]. 2020 [cited 2020 Jul 13];34(6):1637-45. Available from: https://doi.org/10.1038/s41375-020-0836-7 https://doi.org/10.1038/s41375-020-0836-... , A152727. Rogado J, Pangua C, Serrano-Montero G, Obispo B, Marino AM, Pérez-Pérez M, et al. Covid-19 and lung cancer: A greater fatality rate? Lung Cancer [Internet]. 2020 [cited 2020 Jul 12];146:19-22. Available from: https://doi.org/10.1016/j.lungcan.2020.05.034 https://doi.org/10.1016/j.lungcan.2020.0...	2 (8)

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