Imunização de camundongos com «vacina» viva avirulenta de Trypanosoma cruzi

Menezes, Humberto

doi:10.1590/S0037-86821969000600001

Resumos

O Autor procura verificar qual o menor número de Trypanosoma cruzi, da cepa Y avirulenta, capaz de conferir a camundongos imunidade eficiente contra uma ulterior infecção com a cepa Y virulenta do mesmo parasita. Considerações gerais sôbre o possível mecanismo da imunização são esboçadas.

After having demonstrated that the cultivated Y strain of Trypanosoma cruzi became avirulent to laboratory animais without losing its protective activity against a further virulent infection, the Author concludes that a very small dose of live trypanosomes (about 3 metaciclic forms per gram of body weight) is able to afford good immunity to mice. General considerations about the probable mechanism of the immunity are made.

Imunização de camundongos com «vacina» viva avirulenta de Trypanosoma cruzi

Humberto Menezes

U.S.P. Departamento de Patologia. Faculdade de Medicina de Ribeirão Prêto, São Paulo, Brasil

RESUMO

O Autor procura verificar qual o menor número de Trypanosoma cruzi, da cepa Y avirulenta, capaz de conferir a camundongos imunidade eficiente contra uma ulterior infecção com a cepa Y virulenta do mesmo parasita.

Considerações gerais sôbre o possível mecanismo da imunização são esboçadas.

ABSTRACT

After having demonstrated that the cultivated Y strain of Trypanosoma cruzi became avirulent to laboratory animais without losing its protective activity against a further virulent infection, the Author concludes that a very small dose of live trypanosomes (about 3 metaciclic forms per gram of body weight) is able to afford good immunity to mice. General considerations about the probable mechanism of the immunity are made.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

BIBLIOGRAFIA

1. BRENER, Z. - Contribuição ao estudo da terapêutica experimental da Doença de Chagas. Tese. Fac. Farm. Odont. Univ. Minas Gerais, Belo Horizonte, 1961.
2. CAPPA, S.M.G.; SCHMUNIS, G.A.; TRAVERSA, O. C.; YAVANOVSKY, J.F. & PARODI, A.S. - Complement fixation tests skin test and experimental immunization with antigens of T. cruzi prepared under pressure. Am. J. Trop. Med. & Hyg. 17: .... 709-715, 1968.
3. COLLIER, W. - Über Immunität bei du Chagas Krankheit du Weissen mans. Z. Hyg. Infektionskr. 112: .. 88-92, 1931.
4. GOBLE, F.C. - Experimental immunology 8.^th Int. Cong. Trop. Med. & Malaria. Teheran. 1968. Abstracts & Reviews. Pág. 366.
5. LUMSDEN, W.H.R. - Trends in Research on the Immunology of Trypanosomias. Bull. Wld. Hlth. Org. 37: 167-175, 1967.
6. MENEZES, H. - The effect of phenolated "vaccines" against experimental infection in mice. Rev. Inst. Med. Trop. São Paulo, 2:59-66 1968.
7. MENEZES, H. - Protective effect of on avirulent (Oultivated) strain of Trypanosoma cruzi against experimental infection in mice. Rev. Inst. Med. Trop. São Paulo, 10: 1-4, 1968.
8. MENEZES, H. - Lesões histológicas em camundongos "vacinados" com uma cepa avirulenta do Trypanosoma cruzi, Rev. Brasil. Med. 25: 160-165, 1968.
9. MENEZES, H. - I - The avirulence of the cultivated Y strain of Trypanosoma cruzi Rev. Int. Med. trop. São Paulo. No prelo.
10. MENEZES, H. - II - The avirulence of the cultivated Y strain of Trypanosoma cruzi Em preparo.
11. MENEZES, H. - Active immunization of mice with the avirulent Y strain of Trypanosoma cruzi against heterologous virulent strains of the same parasite. Rev. Inst. Med. trop. São Paulo. No prelo.
12. MENEZES, H. - Lesões histológicas do coração em cães "vacinados" com uma cepa avirulenta do Trypanosoma cruzi Rev. Bras. Med. No prelo.
13. MENEZES, H. - Active immunization of dogs with a non virulent strain of Trypanosoma cruzi Rev. Inst. Med. trop. São Paulo. No prelo.
14. SENECA, H. - Current status of immunization of laboratory animais with T. cruzi lipopolysacharide. 8.^th Int. Cong. Trop. Med. & Malaria. Teheran. 1968. Abstracts & Reviews. Pag. 367.

Datas de Publicação

Publicação nesta coleção
01 Ago 2013
Data do Fascículo
Dez 1969

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. BRENER, Z. - Contribuição ao estudo da terapêutica experimental da Doença de Chagas. Tese. Fac. Farm. Odont. Univ. Minas Gerais, Belo Horizonte, 1961.

[2] 2. CAPPA, S.M.G.; SCHMUNIS, G.A.; TRAVERSA, O. C.; YAVANOVSKY, J.F. & PARODI, A.S. - Complement fixation tests skin test and experimental immunization with antigens of T. cruzi prepared under pressure. Am. J. Trop. Med. & Hyg. 17: .... 709-715, 1968.

[3] 3. COLLIER, W. - Über Immunität bei du Chagas Krankheit du Weissen mans. Z. Hyg. Infektionskr. 112: .. 88-92, 1931.

[4] 4. GOBLE, F.C. - Experimental immunology 8.^th Int. Cong. Trop. Med. & Malaria. Teheran. 1968. Abstracts & Reviews. Pág. 366.

[5] 5. LUMSDEN, W.H.R. - Trends in Research on the Immunology of Trypanosomias. Bull. Wld. Hlth. Org. 37: 167-175, 1967.

[6] 6. MENEZES, H. - The effect of phenolated "vaccines" against experimental infection in mice. Rev. Inst. Med. Trop. São Paulo, 2:59-66 1968.

[7] 7. MENEZES, H. - Protective effect of on avirulent (Oultivated) strain of Trypanosoma cruzi against experimental infection in mice. Rev. Inst. Med. Trop. São Paulo, 10: 1-4, 1968.

[8] 8. MENEZES, H. - Lesões histológicas em camundongos "vacinados" com uma cepa avirulenta do Trypanosoma cruzi, Rev. Brasil. Med. 25: 160-165, 1968.

[9] 9. MENEZES, H. - I - The avirulence of the cultivated Y strain of Trypanosoma cruzi Rev. Int. Med. trop. São Paulo. No prelo.

[10] 10. MENEZES, H. - II - The avirulence of the cultivated Y strain of Trypanosoma cruzi Em preparo.

[11] 11. MENEZES, H. - Active immunization of mice with the avirulent Y strain of Trypanosoma cruzi against heterologous virulent strains of the same parasite. Rev. Inst. Med. trop. São Paulo. No prelo.

[12] 12. MENEZES, H. - Lesões histológicas do coração em cães "vacinados" com uma cepa avirulenta do Trypanosoma cruzi Rev. Bras. Med. No prelo.

[13] 13. MENEZES, H. - Active immunization of dogs with a non virulent strain of Trypanosoma cruzi Rev. Inst. Med. trop. São Paulo. No prelo.

[14] 14. SENECA, H. - Current status of immunization of laboratory animais with T. cruzi lipopolysacharide. 8.^th Int. Cong. Trop. Med. & Malaria. Teheran. 1968. Abstracts & Reviews. Pag. 367.