The vaccination of human beings with a live avirulent strain of Trypanosoma cruzi: a new series of volunteers

Menezes, Humberto

doi:10.1590/S0037-86821973000200002

Abstracts

Five human volunteers were vaccinated with a live avirulent strain of Trypanosoma cruzi and followed-up for one year. Except for a few cases of questionable results presented by only one Laboratory, ali the other clinicai, parasitological and serological tests remained negative during that period.

Cinco voluntários humanos foram vacinados com tripanosomas vivos de uma cepa avirulenta de T. cruzi e seguidos durante um ano. Exceto alguns poucos resultados serológicos conflitantes apresentados por um mesmo Laboratório, exames idênticos realizados simultâneamente em outros Laboratórios deram resultados negativos. Os exames clínicos e parasitológicos se mantiveram uniformemente negativos no decorrer de toda a experimentação.

The vaccination of human beings with a live avirulent strain of Trypanosoma cruzi. A new series of volunteers

Humberto Menezes

Associate Professor, Departamento de Genética e Matemática Aplicada à Biologia, Faculdade de Medicina. USP. 14100 Ribeirão Preto, Est. S. Paulo, Brasil

ABSTRACT

Five human volunteers were vaccinated with a live avirulent strain of Trypanosoma cruzi and followed-up for one year. Except for a few cases of questionable results presented by only one Laboratory, ali the other clinicai, parasitological and serological tests remained negative during that period.

RESUMO

Cinco voluntários humanos foram vacinados com tripanosomas vivos de uma cepa avirulenta de T. cruzi e seguidos durante um ano.

Exceto alguns poucos resultados serológicos conflitantes apresentados por um mesmo Laboratório, exames idênticos realizados simultâneamente em outros Laboratórios deram resultados negativos.

Os exames clínicos e parasitológicos se mantiveram uniformemente negativos no decorrer de toda a experimentação.

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Submitted to publication on 11.22.1972.

1. HUNGERER, K. D. - The immunology of experimental Chaga's disease. Conference at The Depat. Doenças Infect. Fac. Med. USP. Feb. 12, 1972.
2. MENEZES, H. - Protective effect of an avirulent (cultivated) strain of Trypanosoma cruzi against experimental infection in mice. Rev. Inst. Med. Trop. S. Paulo 10: 1-4, 1968.
3. Active immunization of dogs with a non virulent strain of T. cruzi. Rev. Inst. Med. Trop. S. Paulo, 11: 258-263, 1969.
4. ____ I. The avirulence of the cultivated Y strain of Trypanosoma cruzi. Rev. Inst. Med. Trop. S. Paulo, 12: 64- 68, 1970.
5. ____ II. The avirulence of the cultivated Y strain of Trypanosoma cruzi. Rev. Inst. Med. Trop. S. Paulo, 12: 129-135, 1970.
6. ____ III. The avirulence of the cultivated Y strain of Trypanosoma cruzi. Rev. Inst. Med. Trop. S. Paulo, 13: 14-17, 1971.
7. IV. The avirulence of the cultivated Y strain of Trypanosoma cruzi. Rev. Soc. Bras. Med. Trop. 5: 214-233, 1971.
8. MENEZES, H. & RIBEIRO, R. - V. The avirulence of the cultivated PF strain of T. cruzi. The evaluation of parasitologic tests after vaccination of different animal species. Rev. Soc. Bras. Med. Trop. 6: 41-48, 1972.
9. MENEZES H. - VI. The avirulence of the cultivated PF strain of Trypanosoma cruzi. Induced immunotolerance in mice by a very high inoculum. Rev. Soc. Bras. Med. Trop. 6: 79-84, 1972.
10. MENEZES, H. & ALBUQUERQUE, R. D. R. - Imunização de camundongos com vacina viva avirulenta de Trypanosoma cruzi. III. Vacinação do meio de cultura. Rev.-Soc. Bras. Med. Trop., 4: 69-74, 1970.
11. MENEZES, H. - Aplicação de vacina viva avirulenta do Trypanosoma cruzi em seres humanos. Nota prévia. Rev. Inst. Med. Trop. S. Paulo, 13: 144-154, 1971.
12. MENEZES, H. - The vaccination of human beings with live avirulent vaccine of Trypanoroma cruzi. A two year follow-up of the first two cases. Rev. Soc. Bras. Med. Trop. In press.
13. RIBEIRO DOS SANTOS, R. - Personal communication. 1972.
14. RIBEIRO DOS SANTOS, R. - Imunização passiva de camundongos isogênicos por linfócitos sensibilizados com a cepa PF de Trypanosoma cruzi. Meeting at the Dept. Trop. Dis. USP. S. Paulo, June 16, 1972.

Publication Dates

Publication in this collection
21 June 2013
Date of issue
Apr 1973

History

Accepted
22 Nov 1972
Received
22 Nov 1972

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. HUNGERER, K. D. - The immunology of experimental Chaga's disease. Conference at The Depat. Doenças Infect. Fac. Med. USP. Feb. 12, 1972.

[2] 2. MENEZES, H. - Protective effect of an avirulent (cultivated) strain of Trypanosoma cruzi against experimental infection in mice. Rev. Inst. Med. Trop. S. Paulo 10: 1-4, 1968.

[3] 3. Active immunization of dogs with a non virulent strain of T. cruzi. Rev. Inst. Med. Trop. S. Paulo, 11: 258-263, 1969.

[4] 4. ____ I. The avirulence of the cultivated Y strain of Trypanosoma cruzi. Rev. Inst. Med. Trop. S. Paulo, 12: 64- 68, 1970.

[5] 5. ____ II. The avirulence of the cultivated Y strain of Trypanosoma cruzi. Rev. Inst. Med. Trop. S. Paulo, 12: 129-135, 1970.

[6] 6. ____ III. The avirulence of the cultivated Y strain of Trypanosoma cruzi. Rev. Inst. Med. Trop. S. Paulo, 13: 14-17, 1971.

[7] 7. IV. The avirulence of the cultivated Y strain of Trypanosoma cruzi. Rev. Soc. Bras. Med. Trop. 5: 214-233, 1971.

[8] 8. MENEZES, H. & RIBEIRO, R. - V. The avirulence of the cultivated PF strain of T. cruzi. The evaluation of parasitologic tests after vaccination of different animal species. Rev. Soc. Bras. Med. Trop. 6: 41-48, 1972.

[9] 9. MENEZES H. - VI. The avirulence of the cultivated PF strain of Trypanosoma cruzi. Induced immunotolerance in mice by a very high inoculum. Rev. Soc. Bras. Med. Trop. 6: 79-84, 1972.

[10] 10. MENEZES, H. & ALBUQUERQUE, R. D. R. - Imunização de camundongos com vacina viva avirulenta de Trypanosoma cruzi. III. Vacinação do meio de cultura. Rev.-Soc. Bras. Med. Trop., 4: 69-74, 1970.

[11] 11. MENEZES, H. - Aplicação de vacina viva avirulenta do Trypanosoma cruzi em seres humanos. Nota prévia. Rev. Inst. Med. Trop. S. Paulo, 13: 144-154, 1971.

[12] 12. MENEZES, H. - The vaccination of human beings with live avirulent vaccine of Trypanoroma cruzi. A two year follow-up of the first two cases. Rev. Soc. Bras. Med. Trop. In press.

[13] 13. RIBEIRO DOS SANTOS, R. - Personal communication. 1972.

[14] 14. RIBEIRO DOS SANTOS, R. - Imunização passiva de camundongos isogênicos por linfócitos sensibilizados com a cepa PF de Trypanosoma cruzi. Meeting at the Dept. Trop. Dis. USP. S. Paulo, June 16, 1972.