Baldwin et al.1515. Baldwin C, Nolan VG, Wyszynski DF, Ma QL, Sebastiani P, Embury SH, et al. Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis. Blood. 2005;106:372-5. http://doi.org/10.1182/blood-2005-02-0548 http://doi.org/10.1182/blood-2005-02-054...
|
BMP6, KL and ANXA2 |
Multiple logistic regression; OR |
For KL, ten polymorphisms were associated with osteonecrosis, for BMP6 five, and, for ANXA2, 6 had the same association (p<0.050) |
Chaouch et al.1818. Chaouch L, Kalai M, Jbara MB, Chaabene AB, Darragi I, Chaouachi D, et al. Association between rs267196 and rs267201 of BMP6 gene and osteonecrosis among sickle cell aneamia patients. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015;159:145-9. http://doi.org/10.5507/bp.2013.080 http://doi.org/10.5507/bp.2013.080...
|
BMP6 |
Fisher’s exact test, chi-square test, logistic regression, RR |
rs267196 and rs267201 (RR of 1.31) of BMP6 can be considered biomarkers for AVN in SCD. |
Kutlar et al.2323. Kutlar A, Kutlar F, Turker I, Tural C. The methylene tetrahydrofolate reductase (C677T) mutation as a potential risk factor for avascular necrosis in sickle cell disease. Hemoglobin. 2001;25:213-7. http://doi.org/10.1081/hem-100104029 http://doi.org/10.1081/hem-100104029...
|
MTHFR |
chi-square test |
MTHFR may be associated with AVN in SCD (p=0.006) |
Pandey et al.2727. Pandey S, Ranjan R, Pandey S, Mishra RM, Seth T, Saxena R. Effect of ANXA2 gene single nucleotide polymorphism (SNP) on the development of osteonecrosis in Indian sickle cell patient: a PCR-RFLP approach. Indian J Exp Biol. 2012;50(7):455-8. |
ANXA2 |
chi-square test |
The polymorphism in the ANXA2 rs7170178 gene was more frequent in patients with osteonecrosis |
Hatzlhofer et al.1414. Hatzlhofer BL, Bezerra MA, Santos MN, Albuquerque DM, Freitas EM, Costa FF, et al. MTHFR polymorphic variant C677T is associated to vascular complications in sickle-cell disease. Genet Test Mol Biomarkers. 2012;16:1038-43. http://doi.org/10.1089/gtmb.2011.0361 http://doi.org/10.1089/gtmb.2011.0361...
|
MTHFR |
Fisher’s exact test, chi-square test, OR |
No association (p=0,170) |
Nebor et al., 2010. |
Duffy antigen/chemokine receptor (DARC) |
Pearson, Student’s t-test or non-parametric Mann-Whitney test |
No association (p=1,000) |
Moreira Neto et al.2525. Moreira Neto F, Lourenço DM, Noguti MA, Morelli VM, Gil IC, Beltrão AC, et al. The clinical impact of MTHFR polymorphism on the vascular complications of sickle cell disease. Braz J Med Biol Res. 2006;39:1291-5. |
MTHFR, factor V and prothrombin |
Mann-Whitney nonparametric test and Fisher test |
No association |
Farawela et al.1616. Farawela HM, El-Ghamrawy M, Farhan MS, Soliman R, Yousry SM, AbdelRahman HA. Association between Duffy antigen receptorexpression and disease severity in sickle cell disease patients. Hematology. 2016;8:474-9. http://doi.org/10.1080/10245332.2015.1111643 http://doi.org/10.1080/10245332.2015.111...
|
Duffy antigen/chemokine receptor (DARC) |
Fisher’s test, Kruskal-Wallis test and Student’s t test |
No association (p=1,000) |
Kalai et al.2828. Kalai M, Dridi M, Chaouch L, Moumni I, Ouragini H, Darragi I, et al. The role of rs1984112_G at CD36 gene in increasing reticulocyte level among sickle cell disease patients. Hematology. 2017;22(3):178-82. http://doi.org/10.1080/10245332.2016.1253253 http://doi.org/10.1080/10245332.2016.125...
|
CD36-rs1984112 |
Mann-Whitney nonparametric test and Student’s t test |
No association (p=1,000). |
Zimmerman et al.2929. Zimmerman SA, Howard TA, Whorton MR, Rosse WF, James AH, Ware RE. Thrombophilic DNA mutations as independent risk factors for stroke and avascular necrosis in sickle cell anemia. Hematology. 2001;6(5):347-53. http://doi.org/10.1080/10245332.2001.11746590 http://doi.org/10.1080/10245332.2001.117...
|
Thrombolytic mutations* |
Chi-square test, standard error and CART analysis |
No association (p>0,050). |
Zimmerman et al.3030. Zimmerman SA, Ware RE. Inherited DNA mutations contributing to thrombotic complications in patients with sickle cell disease. Am J Hematol. 1998;59(4):267-72. http://doi.org/10.1002/(sici)1096-8652(199812)59:4<267::aid-ajh1>3.0.co;2-w http://doi.org/10.1002/(sici)1096-8652(1...
|
MTHFR and GPilla |
Chi-square test and Student’s t test |
No association (p>0,050) |
Adekile et al.3131. Adekile AD, Kutlar F, Haider MZ, Kutlar A. Frequency of the 677 C-->T mutation of the methylenetetrahydrofolate reductase gene among Kuwaiti sickle cell disease patients. Am J Hematol. 2001;66(4):263-6. http://doi.org/10.1002/ajh.1055 http://doi.org/10.1002/ajh.1055...
|
MTHFR (C677T) |
Not informed |
The frequency of the MTHFR polymorphism (C677T) was the same with or without AVN (21.4%) |