Effectiveness of cinnamon in the reduction of lipid levels in people with diabetes: a randomized clinical trial

Lira Neto, José Cláudio Garcia; Araújo, Márcio Flávio Moura de; Araújo, Antônia Vitória Elayne Carneiro; Figueira, Joana Nágila Ribeiro; Maranhão, Thatiana Araújo; Damasceno, Marta Maria Coelho

doi:10.1590/1983-1447.2023.20230051.en

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Original Article • Rev. Gaúcha Enferm. 44 • 2023 • https://doi.org/10.1590/1983-1447.2023.20230051.en copy

Effectiveness of cinnamon in the reduction of lipid levels in people with diabetes: a randomized clinical trial

Eficacia de la canela en la reducción de los niveles de lípidos en personas con diabetes: un ensayo clínico aleatorizado

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Objective:

To evaluate the effectiveness of cinnamon in reducing lipid levels in people with diabetes.

Method:

Randomized clinical trial of parallel groups, triple-blind, conducted in Basic Health Units in the state of Piauí in 2019. People with Type 2 Diabetes Mellitus, between 18 and 80 years old, using oral antidiabetics, were included, and divided into two groups. The experimental group tested 3g of cinnamon for 90 days.

Results:

140 people participated in the study. From these, the experimental group (n= 71) showed a reduction in mean levels of total cholesterol (p= 0.316 | CI 95% -24.9-8.1), LDL (p= 0.024 | CI 95% -29.3 -2.1) and triglycerides (p= 0.969 | 95% CI -28.6-27.5), and increased HDL (p= 0.001 | 95% CI 4.2-10.2).

Conclusion:

The use of 3g of cinnamon per day, for 90 days, seems to help reduce LDL values and increase HDL levels in patients with diabetes.

Descriptors:
Cinnamomum zeylanicum; Diabetes Mellitus type 2; Lipids; Clinical trial

Biomarker	Experimental Group (n= 71)						Control Group (n= 69)
Biomarker	Start x̅ (±SD)	End x̅ (±SD)	p ¹	MD	CI95%	Conhen’s d²	Start x̅ (±SD)	End x̅ (±SD)	p ¹	MD	CI95%	Conhen’s d²
TC (mg/dL)	205.3±44.8	196.9±42.5	0.316	-8.3	-24.9-8.1	-0.11	207.2±41.1	213.7±49	0.325	6.4	-6.5-19.5	0.11
HDL (mg/dL)	52.7±11.5	60±9.6	<0.001	7.23	4.2-10.2	0.56	51.9±9.1	57.8±10.4	<0.001	5.9	2.9-8.9	0.47
LDL (mg/dL)	120.6±37.8	104.8±39.5	0.024	-15.7	-29.3-2.1	-0.27	116.5±32.3	119.2±41.3	0.631	2.6	-8.4-13.8	0.06
TG (mg/dL)	186.4±96.5	185.9±83	0.969	-0.54	-28.6-27.5	-0.01	201.1±101	251.4±125.1	0.007	50.2	14.5-86	0.33

Variables	EG (n= 71)	CG (n= 69)	p-value*
High TC (≥190 mg/dL),% yes (n)
Initial	60.6 (43)	72.5 (50)	0.16
Final	56.3 (40)	66.7 (46)	0.23
Change of category
No change**	70.4 (50)	76.8 (53)	0.67
Normal, High	12.7 (9)	8.7 (6)
High, Normal (desired)	16.9 (12)	14.5 (10)
Low HDL (≤ 40mg/dL), % yes(n)
Initial	15.5 (11)	11.6 (8)	0.62
Final	1 (1,4)	5.8 (4)	0.20
Change of category
No change**	85.9 (61)	91.3 (63)	0.28
Normal, Low	0.0 (0)	1.4 (1)
Low, Normal (desired)	14.1 (10)	7.2 (5)
High LDL*** (≥100 mg/dL), % yes (n)
Initial	70.4 (50)	65.2 (45)	0.59
Final	52.1 (37)	60.9 (42)	0.31
Change of category
No change**	70.4 (50)	78.3 (54)	0.23
Normal, High	5.6 (4)	8.7 (6)
High, Normal (desired)	23.9 (17)	13.0 (9)
High TG (≥150 mg/dL), % sim (n)
Initial	59.2 (42)	69.6 (48)	0.22
Final	64.8 (46)	84.1 (58)	0.01
Change of category
No change**	77.5 (55)	79.7 (55)	0.41
Normal, High	14.1 (10)	17.4 (12)
High, Normal (desired)	8.5 (6)	2.9 (2)

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[1] Corresponding author:
José Cláudio Garcia Lira Neto E-mail: jclira@live.com