Evaluation of the maturational auditory process in children with the infection by Zika congenital syndrome

Lucas, Priscila de A; Santos, Walkiria B; Oliveira, Thalita M de; Galera, Marcial F

doi:10.1590/1982-0216/20242629823

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ORIGINAL ARTICLES • Rev. CEFAC 26 (2) • 2024 • https://doi.org/10.1590/1982-0216/20242629823 copy

Evaluation of the maturational auditory process in children with the infection by Zika congenital syndrome

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Purpose:

to analyze the absolute latencies of waves I. III and V and the interpeak intervals I-III. III-V and I-V of the ABR recorded from different age groups of children with congenital zika virus infection and their peers without risk indicators for hearing impairment.

Methods:

84 newborns and infants (N=51 study group and N=33 control group) divided into groups with different post-conceptual ages. with the results of their hearing exams analyzed by age group and compared with their peers without other risk indicators for hearing impairment. The assessment of the auditory pathway was conducted through tympanometry. otoacoustic emissions and auditory brain stem responses.

Results:

only the latency of wave I and the interpeak III-V showed no significant difference between the study and control groups. The absolute latency and interpeak values found in the study group were significantly lower than those found in the control group.

Conclusion:

the maturation of the brain stem in children with ZIKV infection occurred within normal limits. with no retrocochlear disorders until the age of 5 years.

Keywords:
Zika Virus; Evoked Potentials, Auditory, Brain Stem; Hearing; Arbovirus Infections

Absolute latencies and interpeak intervals		Mean	Median	Standard deviation	CV	Min	Max	N	CI	P-value
Latency I	RE	1.58	1.56	0.15	9%	1.33	2.12	84	0.03	0.361
Latency I	LE	1.59	1.61	0.12	8%	1.33	1.88	84	0.03	0.361
Latency III	RE	4.05	4.05	0.40	10%	3.15	5.00	84	0.08	0.448
Latency III	LE	4.04	4.01	0.37	9%	3.33	4.85	84	0.08	0.448
Latency V	RE	6.17	6.26	0.53	9%	5.15	7.18	84	0.11	0.370
Latency V	LE	6.16	6.17	0.51	8%	5.15	7.09	84	0.11	0.370
Interpeak I-III	RE	2.46	2.49	0.34	14%	1.73	3.33	84	0.07	0.356
Interpeak I-III	LE	2.44	2.46	0.35	14%	1.66	3.28	84	0.07	0.356
Interpeak III-V	RE	2.12	2.10	0.26	12%	1.67	2.83	84	0.06	0.869
Interpeak III-V	LE	2.13	2.12	0.28	13%	1.38	3.11	84	0.06	0.869
Interpeak I-V	RE	4.58	4.60	0.48	11%	3.56	5.42	84	0.10	0.123
Interpeak I-V	LE	4.55	4.59	0.48	11%	3.42	5.52	84	0.10	0.123

Absolute latencies and interpeak intervals			Mean	Median	Standard deviation	CV	Min	Max	N	CI	P-value
Latency I	Range 1	Control	1.61	1.59	0.13	8%	1.42	1.82	22	0.05	0.347
	Range 1	Study	1.64	1.62	0.13	8%	1.33	1.88	44	0.04	0.347
	Range 2	Control	1.58	1.54	0.15	10%	1.36	2.12	32	0.05	0.899
	Range 2	Study	1.59	1.58	0.09	6%	1.44	1.85	32	0.03	0.899
	Range 3	Control	1.50	1.50	0.11	7%	1.37	1.67	12	0.06	0.520
	Range 3	Study	1.53	1.53	0.14	9%	1.33	1.84	26	0.05	0.520
	General	Control	1.58	1.55	0.14	9%	1.36	2.12	66	0.03	0.358
	General	Study	1.60	1.59	0.13	8%	1.33	1.88	102	0.03	0.358
Latency III	Range 1	Control	4.32	4.27	0.25	6%	3.97	4.74	22	0.10	0.703
	Range 1	Study	4.29	4.21	0.35	8%	3.50	5.00	44	0.10	0.703
	Range 2	Control	4.19	4.20	0.23	6%	3.82	4.64	32	0.08	<0.001*
	Range 2	Study	3.89	3.91	0.24	6%	3.48	4.41	32	0.08	<0.001*
	Range 3	Control	3.76	3.77	0.17	5%	3.48	3.98	12	0.10	0.001*
	Range 3	Study	3.53	3.53	0.19	5%	3.15	3.92	26	0.07	0.001*
	General	Control	4.16	4.19	0.30	7%	3.48	4.74	66	0.07	0.002*
	General	Study	3.97	3.95	0.42	10%	3.15	5.00	102	0.08	0.002*
Latency V	Range 1	Control	6.58	6.65	0.35	5%	5.75	7.18	22	0.15	0.559
	Range 1	Study	6.53	6.62	0.38	6%	5.70	7.06	44	0.11	0.559
	Range 2	Control	6.36	6.45	0.31	5%	5.79	6.84	32	0.11	<0.001*
	Range 2	Study	5.96	5.97	0.26	4%	5.45	6.54	32	0.09	<0.001*
	Range 3	Control	5.64	5.61	0.22	4%	5.31	5.94	12	0.13	0.009*
	Range 3	Study	5.45	5.44	0.20	4%	5.15	5.97	26	0.08	0.009*
	General	Control	6.31	6.41	0.45	7%	5.31	7.18	66	0.11	0.004*
	General	Study	6.07	6.06	0.54	9%	5.15	7.06	102	0.10	0.004*
Interpeak I-III	Range 1	Control	2.71	2.64	0.23	8%	2.43	3.14	22	0.09	0.290
	Range 1	Study	2.64	2.56	0.30	11%	2.03	3.33	44	0.09	0.290
	Range 2	Control	2.61	2.55	0.21	8%	2.27	3.15	32	0.07	<0.001*
	Range 2	Study	2.31	2.31	0.22	9%	1.90	2.74	32	0.08	<0.001*
	Range 3	Control	2.26	2.27	0.16	7%	2.08	2.53	12	0.09	<0.001*
	Range 3	Study	1.99	2.02	0.19	9%	1.66	2.37	26	0.07	<0.001*
	General	Control	2.58	2.54	0.26	10%	2.08	3.15	66	0.06	<0.001*
	General	Study	2.37	2.36	0.36	15%	1.66	3.33	102	0.07	<0.001*
Interpeak III-V	Range 1	Control	2.26	2.28	0.25	11%	1.78	2.70	22	0.11	0.975
	Range 1	Study	2.26	2.21	0.28	12%	1.80	3.11	44	0.08	0.975
	Range 2	Control	2.17	2.15	0.26	12%	1.38	2.57	32	0.09	0.054
	Range 2	Study	2.07	2.03	0.14	7%	1.76	2.34	32	0.05	0.054
	Range 3	Control	1.88	1.88	0.16	9%	1.69	2.19	12	0.09	0.720
	Range 3	Study	1.91	1.91	0.20	11%	1.45	2.24	26	0.08	0.720
	General	Control	2.15	2.14	0.27	13%	1.38	2.70	66	0.07	0.391
	General	Study	2.11	2.10	0.27	13%	1.45	3.11	102	0.05	0.391
Interpeak I-V	Range 1	Control	4.98	4.98	0.34	7%	4.21	5.49	22	0.14	0.223
	Range 1	Study	4.86	4.97	0.35	7%	4.10	5.52	44	0.10	0.223
	Range 2	Control	4.78	4.75	0.31	6%	4.22	5.36	32	0.11	<0.001*
	Range 2	Study	4.37	4.43	0.25	6%	3.84	4.81	32	0.09	<0.001*
	Range 3	Control	4.14	4.14	0.20	5%	3.84	4.49	12	0.11	0.002*
	Range 3	Study	3.90	3.85	0.22	6%	3.42	4.39	26	0.08	0.002*
	General	Control	4.73	4.77	0.42	9%	3.84	5.49	66	0.10	<0.001*
	General	Study	4.46	4.44	0.49	11%	3.42	5.52	102	0.10	<0.001*

Absolute latencies and interpeak intervals		Mean	Median	Standard deviation	CV	Min	Max	N	CI	P-value
Latency I	Range 1	1.59	1.54	0.12	8%	1.50	1.88	12	0.07	0.849
	Range 2	1.57	1.54	0.08	5%	1.48	1.70	12	0.05
	Range 3	1.59	1.61	0.14	9%	1.40	1.84	12	0.08
Latency III	Range 1	4.06	4.11	0.24	6%	3.50	4.33	12	0.13	<0.001*
	Range 2	3.69	3.63	0.16	4%	3.48	3.97	12	0.09
	Range 3	3.51	3.48	0.21	6%	3.18	3.92	12	0.12
Latency V	Range 1	6.32	6.35	0.47	8%	5.70	7.03	12	0.27	<0.001*
	Range 2	5.75	5.76	0.22	4%	5.45	5.97	12	0.13
	Range 3	5.37	5.41	0.14	3%	5.15	5.60	12	0.08
Interpeak I-III	Range 1	2.47	2.55	0.17	7%	2.03	2.61	12	0.10	<0.001*
	Range 2	2.12	2.11	0.16	7%	1.90	2.43	12	0.09
	Range 3	1.91	1.88	0.15	8%	1.66	2.19	12	0.09
Interpeak III-V	Range 1	2.22	2.22	0.34	15%	1.80	2.82	12	0.19	0.027*
	Range 2	2.06	2.00	0.14	7%	1.91	2.34	12	0.08
	Range 3	1.84	1.90	0.21	11%	1.45	2.18	12	0.12
Interpeak I-V	Range 1	4.69	4.73	0.45	10%	4.10	5.42	12	0.26	<0.001*
	Range 2	4.18	4.18	0.23	5%	3.84	4.49	12	0.13
	Range 3	3.75	3.80	0.16	4%	3.42	4.00	12	0.09

Absolute latencies and interpeak intervals		Range 1	Range 2
Latency III	Range 2	<0.001*
Latency III	Range 3	<0.001*	0.021*
Latency V	Range 2	0.002*
Latency V	Range 3	<0.001*	<0.001*
Interpeak I-III	Range 2	<0.001*
Interpeak I-III	Range 3	<0.001*	0.006*
Interpeak III-V	Range 2	0.150
Interpeak III-V	Range 3	0.009*	0.022*
Interpeak I-V	Range 2	0.002*
Interpeak I-V	Range 3	<0.001*	<0.001*

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[1] Corresponding author: Priscila de Araújo Lucas, Avenida Bosque da Saúde 841/123 - Bosque da Saúde, Zipcode: 78050-070 - Cuiabá, Mato Grosso, Brazil, E-mail: prilucas@hotmail.com