Hereditary Breast and Ovarian Cancer Screening Syndrome Profile in Women Diagnosed with Breast Cancer from Paraná State Southwest

Moura, Juliana Batista de; Ghedin, Carla Camila; Takakura, Érika Tomie; Scandolara, Thalita Basso; Rech, Daniel; Panis, Carolina

doi:10.1055/s-0041-1733998

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Sumário

Original Article • Rev. Bras. Ginecol. Obstet. 43 (08) • Aug 2021 • https://doi.org/10.1055/s-0041-1733998 copy

Hereditary Breast and Ovarian Cancer Screening Syndrome Profile in Women Diagnosed with Breast Cancer from Paraná State Southwest

Perfil do rastreamento da síndrome hereditária de câncer de mama e ovário em mulheres diagnosticadas com câncer de mama na região sudoeste do Paraná

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Objective

This study evaluated the risk of the hereditary breast and ovarian cancer (HBOC) syndrome in patients with breast cancer by using the Family History Screening 7 (FHS-7) tool, a validated low-cost questionnaire with high sensitivity able to screen the HBOC risk in the population.

Methods

Women diagnosed with breast cancer (n=101) assisted by the Unified Health System at the 8th Regional Health Municipal Office of the state of Paraná answered the FHS-7, and the results were analyzed using IBM SPSS Statistics for Windows, Version 25.0. software (IBM Corp., Armonk, NY, USA).

Results

The risk of HBOC was 19.80% (n=20). Patients at risk exhibited aggressive tumor characteristics, such as high-grade tumors (30%), presence of angiolymphatic emboli (35%), and premenopausal at diagnosis (50%). Significant associations between the prevalence of high-grade tumors were observed inwomen younger than 50 years at diagnosis with HBOC (p=0.003).

Conclusion

Our findings suggest a possible family inheritance associated with worse clinical features in women with breast cancer in this population, indicating that HBOC investigation can be initially performed with low-cost instruments such as FHS-7.

Keywords:
breast cancer; hereditary breast and ovary cancer syndrome; cancer screening; public health

Questions
1. Do you, or any first-degree relative, have or have had breast cancer?
2. Do you or any first-degree relative have or had bilateral breast cancer?
3. Has any man in your family had breast cancer?
4. Did any woman in your family have breast and ovarian cancer?
5. Has any woman in your family had breast cancer before the age of 50?
6. Do you have two or more relatives with breast and / or ovarian cancer?
7. Do you have two or more relatives with breast and / or bowel cancer?

Parameters	Sporadic cancer	HBOC-risk	Chi-squared test
Molecular receptors status
Absence of estrogen receptors	46% (n = 37)	35% (n = 7)
Absence of progesterone receptors	52% (n = 42)	45% (n = 9)	P > 0.05
Absence of HER2 receptors	12% (n = 10)	20% (n = 4)
Molecular subtypesLuminal A	36% (n = 29)	45% (n = 9)	P > 0.05
Luminal B	33% (n = 27)	25% (n = 5)
Luminal-HER2/HER2	12% (n = 10)	10% (n = 2)
Triple-negative	19% (n = 15)	20% (n = 4)
Histological tumor grade			P > 0.05
Low	40% (n = 32)	45% (n = 9)
Intermediate	42% (n = 34)	25% (n = 5)
High	18% (n = 15)	30% (n = 6)
Angiolymphatic emboli			P > 0.05
Presence	33% (n = 27)	35% (n = 7)
Absence	67% (n = 54)	65% (n = 13)
Age at diagnosis			P > 0.05
Under 50 years	40% (n = 32)	35% (n = 7)
Above 50 years	60% (n = 49)	65% (n = 13)
Body mass index (BMI, kg/m²)			P > 0.05
Eutrophic	36% (n = 29)	50% (n = 10)
Overweight	40% (n = 32)	25% (n = 5)
Obese	24% (n = 19)	25% (n = 5)
Menopause Status at diagnosis			P > 0.05
Yes	52% (n = 42)	50% (n = 10)
No	48% (n = 39)	50% (n = 10)
Lymphnodal involvement			P > 0.05
Yes	24% (n = 19)	25% (n = 5)
No	76% (n = 62)	75% (n = 15)

Federação Brasileira das Sociedades de Ginecologia e Obstetrícia Av. Brigadeiro Luís Antônio, 3421, sala 903 - Jardim Paulista, 01401-001 São Paulo SP - Brasil, Tel. (55 11) 5573-4919 - Rio de Janeiro - RJ - Brazil
E-mail: editorial.office@febrasgo.org.br

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[1] Address for correspondence Carolina Panis, Ph.D., Laboratory of Tumor Biology, State University of West Paraná (UNIOESTE), Rodovia Vitorio Traiano Km2, Bairro Água Branca, CEP 85601-970, Francisco Beltrão-Paraná, Brazil (e-mail: carolpanis@hotmail.com).

HBOC-risk	Beta value	p -value
Molecular subtype x histological grade	0.600	0.005
Age x histological grade	0.621	0.003
Angiolymphatic invasion x lymphnodal metastasis	0.545	0.013
Menopause at diagnosis x lymphnodal metastasis	0.577	0.008
Sporadic cancer	Beta value	p -value
Molecular subtype x histological grade	0.225	0.045
Angiolymphatic invasion x lymphnodal metastasis	0.474	0.000