Acessibilidade / Reportar erro

Further development of the baboon as a model for acute schistosomiasis

Abstract

Baboons develop a syndrome, including eosinophilia and transient fever, after infection with carcariae of Schistosoma mansoni that is consistent with the human syndrome of acute schistosomiasis. Radiotelemetry can be used to follow the course of fever in infected baboons. Individual variations in intensity of disease were noted in baboons. These symptoms and signs were more closely linked to the onset of oviposition by the newly matured worms than they were to the presence of migrating schistosoma or maturing worms. The baboon is concluded to be a suitable and useful model for human acute schistosomiasis mansoni.

Schistosoma mansoni; experimental model; acute stage; baboon


ABSTRACT

Further development of the baboon as a model for acute schistosomiasis

Raymond T. Damian1

Miguel A. de la Rosa1

Daniel J. Murfin1

Clarence A. Rawlings2

Peter J. Weina3

Yang Ping Xue1

University of Georgia, Department of Zoology, Athens, U.S.A

University of Georgia, Department of Small Animal Medicine, Athens, U.S.A

Walter Reed Army Institute of Research, Division of Experimental Therapeutics, Department of Parasitology, Washington, U.S.A

Baboons develop a syndrome, including eosinophilia and transient fever, after infection with carcariae of Schistosoma mansoni that is consistent with the human syndrome of acute schistosomiasis. Radiotelemetry can be used to follow the course of fever in infected baboons. Individual variations in intensity of disease were noted in baboons. These symptoms and signs were more closely linked to the onset of oviposition by the newly matured worms than they were to the presence of migrating schistosoma or maturing worms. The baboon is concluded to be a suitable and useful model for human acute schistosomiasis mansoni.

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

Publication Dates

  • Publication in this collection
    04 June 2009
  • Date of issue
    1992
Instituto Oswaldo Cruz, Ministério da Saúde Av. Brasil, 4365 - Pavilhão Mourisco, Manguinhos, 21040-900 Rio de Janeiro RJ Brazil, Tel.: (55 21) 2562-1222, Fax: (55 21) 2562 1220 - Rio de Janeiro - RJ - Brazil
E-mail: memorias@fiocruz.br