Abstract
A histological, morphometric and immunocytochemical study of schistosomal periovular granulomas in the liver and intestines of mice revealed that intestinal granulomas are smaller and contain less collagen than those in the liver. After curative treatment intestinal granulomas undergo a relatively more rapid resorption, although the general pattern of collagen degradation apparently does not differ from that observed in the liver. Tendency to form scattered, usually isolated granulomas that are only mildly fibrogenic, coupled with a well-balanced process of resorption appear as the explanation why intestinal fibrosis is not an outstanding feature of schistosomiasis as it is in the liver.
schistosomiasis; intestinal fibrosis; periovular granuloma
Dynamics of fibrosis production and resorption in intestinal schistosomiasis of mice
Rosella de Oliveira Santos1
Aryon A. Barbosa Júnior1
Zilton A. Andrade
FIOCRUZ, Centro de Pesquisas Gonçalo Moniz, Salvador, Brasil
A histological, morphometric and immunocytochemical study of schistosomal periovular granulomas in the liver and intestines of mice revealed that intestinal granulomas are smaller and contain less collagen than those in the liver. After curative treatment intestinal granulomas undergo a relatively more rapid resorption, although the general pattern of collagen degradation apparently does not differ from that observed in the liver. Tendency to form scattered, usually isolated granulomas that are only mildly fibrogenic, coupled with a well-balanced process of resorption appear as the explanation why intestinal fibrosis is not an outstanding feature of schistosomiasis as it is in the liver.
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Publication Dates
-
Publication in this collection
04 June 2009 -
Date of issue
Mar 1992
