Abstract
Cucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12µg/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).
antitumor; Wilbrandia verticillata; cytotoxicity; Walker carcinosarcoma
Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity
V. S. N. Rao1
F. R. C. Almeida1
A. P. Moraes1
J. V. Silva1
S. C. Nascimento2
M. O. Moraes1
UFC, Departamento de Fisiologia e Farmacologia, Labortório de Pesquisas Antineoplásticas, Fortaleza, Brasil
Universidade Federal de Pernambuco, Departamento de Antibióticos, Recife, Brasil
Cucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12µg/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).
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Publication Dates
-
Publication in this collection
24 June 2009 -
Date of issue
1991
