Sequential production of motor-action verb subtypes in Parkinson's disease patients

Chávez-Oliveros, Mireya; Flores-Lázaro, Julio César; Meza, Haydee Durán; Ramírez-Burgos, Wendy

doi:10.1590/1980-5764-DN-2022-0027

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Dementia & Neuropsychologia

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Short Communication • Dement. neuropsychol. 17 • 2023 • https://doi.org/10.1590/1980-5764-DN-2022-0027 copy

Sequential production of motor-action verb subtypes in Parkinson's disease patients

PRODUÇÃO SEQUENCIAL DE SUBTIPOS DE VERBOS DE AÇÃO MOTORA EM PACIENTES COM DOENÇA DE PARKINSON

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Motor-action verbs (MAVs) production and comprehension are compromised in patients with Parkinson's disease (PD).

Objectives:

The aim of this study was to characterize the sequential production of three subtypes of MAVs in PD patients: whole body (e.g., run), specific body part (e.g., kick), and instrumental (e.g., saw). This study also aimed to identify the production characteristics for each of the two main phases in fluency performance: selection (initial abundant item production) and retrieval (more paced and scarce production).

Methods:

This study involved a group of 20 nondemented, on-medication PD patients, with an average age of 66.59 years (standard deviation = 4.13), and a comparison group (CG) of 20 normal elderly individuals, matched by years of education and controlled for cognitive performance and depression. Both groups performed a classical verb fluency task. Sequential word-by-word analyses were conducted.

Results:

Significant differences were found at the initial production of whole-body MAVs and the overall production of instrumental verbs (both measures were lower in the PD group). A repeated-measures analysis of variance confirmed the linear CG performance and the quadratic PD performance.

Conclusions:

PD patients present altered production of whole-body and instrumental MAVs. This proposal for the semantic sequential analysis of motor verbs deserves further investigation, as a new methodology for the evaluation of fluency performance in motor-related disease.

Keywords:
Parkinson's Disease; Aging; Executive Functions; Language

		Control (n=20)	PD (n=20)	Mean difference
Age		67.74 (5.79)	66.59 (4.13)	0.762^* * Mean differences by Student's t-test;
School years		8.23 (2.26)	7.74 (2.90)	0.547^* * Mean differences by Student's t-test;
MMSE		27.14 (2.53)	27.67 (2.42)	0.506^* * Mean differences by Student's t-test;
Sex		14/6	13/8
Depression^† † Depression scores are obtained from different scales;		8.72 (4.96)	4.50 (3.97)
Years after dx			10.63 (4.71)
Hoehn and Yahr			2.31 (0.34)
Fluency	Total verbs	14.59 (4.96)	12.53 (4.42)	0.156^* * Mean differences by Student's t-test;
	All motor	8.68 (3.69)	5.48 (3.37)	0.012^* * Mean differences by Student's t-test;
	WBA	2.81 (1.79)	1.95 (1.59)	0.091^‡ ‡ Median differences by Kruskal-Wallis test, all groups presented similar distributions.
	Actions	3.18 (1.81)	2.38 (1.65)	0.223^‡ ‡ Median differences by Kruskal-Wallis test, all groups presented similar distributions.
	Instrum	2.68 (2.23)	1.33 (1.60)	0.050^‡ ‡ Median differences by Kruskal-Wallis test, all groups presented similar distributions.
ANOVA repeated measures	All motor verbs	Linear model	Quadratic model
		F=12.007	F=4.839
		p=0.002	p=0.040
		ETA=0.364	ETA=0.195
Covariable effect	School years	F=22.204	F=12.392
		p=0.000	p=0.002
		ETA=0.539	ETA=0.395
	Depression^† † Depression scores are obtained from different scales;	F=6.737	F=4.40
		p=0.018	p=0.049
		ETA=0.262	ETA=0.188
Years after dx			Not significant
Age		Not significant	Not significant
MMSE score		Not significant	Not significant

	Whole-body actions						Specific actions						Instrumental actions
	CG	f	MC	PDG	f	MC	CG	f	MC	PDG	f	MC	CG	f	MC	PDG	f	MC
1	Run	13	6.15	Walk	7	4.86	Eat	20	3.55	Eat	11	3.55	Bath	5	3.93	Bath	3	3.93
2	Hop	13	6.0	Run	7	6.15	Sing	8	2.59	Talk	4	3.30	Wash	4	4.23	Shake	3	4.50
3	Jump	9	5.65	Hop	4	6.0	Read	7	2.30	Sing	4	2.59	Write	5	3.15	Sweep	2	4.41
4	Walk	8	4.86	Dance	4	6.35	Talk	6	3.30	Drink	2	3.0	Sweep	3	4.50	Mop	1	4.63
5	Dance	4	6.35	Swim	2	6.41	Greet	3	2.70	See	2	2.22	Brush	3	3.44	Ax	1	5.37
6	Swim	4	6.41	Walk	1	5.65	Drink	3	3.0	Breath	2	2.88	Iron	2	4.38	Cut	1	2.43
7	Climb	1	6.11	Exercise	1	5.19	Knead	2	3.83	Read	1	2.30	Cook	2	4.38	Dress	1	4.46
8	Box	1	6.19	Jump	1	5.65	Shout	2	2.52	Kick	1	5.27	Dress	1	4.46	Drive	1	4.11
9	Walk	1	5.19	Slide	1	4.0	Swallow	1	3.33	Cough	1	3.65	Smoke	1	2.58	Mount	1	4.41
10										Step	1	3.70	Shake	1	4.92	Knit	1	4.31
Fl		54			33			57			36			38			21
LE	9			9			13			17			15			16
MCAV			5.87			5.58			3.01			3.24			3.99			4.25

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E-mail: revistadementia@abneuro.org.br | demneuropsy@uol.com.br

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[1] Correspondence: Julio César Flores-Lázaro; Email: juliofnp@gmail.com.