ABSTRACT
Objective:
The role of diffusion-weighted MRI in differential diagnostics and predicting the survival of patients with spine metastases was studied.
Methods:
The study included data from MRI and morphological studies of 23 patients with spine metastases.
Results:
The values obtained for the apparent diffusion coefficient (ADC) of tumors were compared with their histological type, cell density and Ki-67 proliferation index. The effect of ADC values on overall patient survival was also assessed. A reliable inverse correlation was established between ADC values and Ki-67 proliferation index for various types of spine metastases (r=-0.753, p=0.017). The dependence of ADC values and overall survival of patients with metastases in the spine is shown.
Conclusion:
The technique of diffusion-weighted MRI can be used as part of a comprehensive assessment in the preoperative planning of surgical treatment, and as a prognostic factor of overall survival for this group of patients. Level of Evidence II. Prognostic retrospective study,
Keywords:
Spine; Neoplasm Metastasis; Diffusion Magnetic Resonance Imaging; Cell Proliferation; Survival
