Associação entre polimorfismos de genes do eixo somatotrópico e eficiência reprodutiva de fêmeas bovinas: revisão de literatura

Contribuições do autor

Conceituação: G. S. Cruz; Análise formal: R. M. S. Correa, L. L. Emerick, E. F. Castilho e M. D. N. Rodrigues; Investigação: G. S. Cruz, L. L. Emerick, D. B. Macedo e E. F. Castilho; Metodologia: G. S. Cruz e D. B. Macedo; Gerenciamento do projeto: M. D. N. Rodrigues; Supervisão: M. D. N. Rodrigues; Redação: G. S. Cruz, R. M. S. Correa e D. B. Macedo.

SNP	Região Polimórfica	Subespécie	Novilha/ Vaca	Característica avaliada	Efeito da associação do SNP com a característica avaliada	Referência
GHR/AluI	Região regulatória	Bos taurus taurus	Vaca	Nº serviços/ gestação; IP; IPC	Manteve	Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )
GHR/AluI	Região regulatória	Bos taurus taurus	Vaca	Nº serviços/gestação	Diminuiu	Schneider et al.(²⁴24 Schneider A, Corrêa MN, Butler WR. Association between growth hormone receptor AluI polymorphism and fertility of Holstein cows. Theriogenology. 2013;80(9):1061-1066. Available from: https://pubag.nal.usda.gov/catalog/612321 https://pubag.nal.usda.gov/catalog/61232... )
GHR rs41 639262	Inespecífico	Bos taurus taurus	Vaca	IPC	Diminuiu	Leyva-Corona et al.(²⁶26 Leyva-Corona JC, Reyna-Granados JR, Zamorano-Algandar R, Sanchez-Castro MA, Thomas MG, EnnsRM, Speidel SE, Medrano JF, Rincon G, Luna-Nevarez P. Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate. Tropical Animal Health and Production. 2018;50, 1913–1920. Available from: https://link.springer.com/article/10.1007/s11250-018-1645-0#citeas https://link.springer.com/article/10.100... )
GHR1.1	Região não codificadora 5′	Bos taurus taurus	Vaca	IP	Diminuiu	Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )
GHR2.6	Região não codificadora 5′	Bos taurus taurus	Vaca	IP	Diminuiu	Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )
GHR4.1	Região não codificadora 5′	Bos taurus taurus	Vaca	IP	Diminuiu	Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )
GHR4.2	Região não codificadora 5′	Bos taurus taurus	Vaca	IP	Diminuiu	Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )
GHR6.1	Região não codificadora 5′	Bos taurus taurus	Vaca	IP	Diminuiu	Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )
GHR9.1	Região não codificadora 5′	Bos taurus taurus	Vaca	IP	Diminuiu	Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )
AF126288: g.149	Promotor do Éxon 1ª	Bos taurus taurus	Vaca	IP	Diminuiu	Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )
GHR19.1	Íntron 2-3	Bos taurus taurus	Vaca	IP	Diminuiu	Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )
F279Y	Éxon 8	Bos taurus taurus	Vaca	IP	Diminuiu	Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )
N528T	Éxon 10	Bos taurus taurus	Vaca	IP	Diminuiu	Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )
A536T	Éxon 10	Bos taurus taurus	Vaca	IP	Diminuiu	Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )
H545	Éxon 10	Bos taurus taurus	Vaca	IP	Diminuiu	Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )
S555G	Éxon 10	Bos taurus taurus	Vaca	IP	Diminuiu	Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )
g.914T>A	Éxon 8	Bos taurus taurus	Vaca	IP	Diminuiu	Fedota et al.(²⁸28 Fedota OM, Lysenko NG, Ruban SYu, Kolisnyk OI, Goraychuk IV. The effects of polymorphisms in growth hormone and growth hormone receptor genes on production and reproduction traits in Aberdeen-Angus cattle (Bos taurus L., 1758). Cytology and Genetics. 2017;51(5):352-360. Available from: https://link.springer.com/article/10.3103/S0095452717050024 https://link.springer.com/article/10.310... )
g.257A>G	Promotor do Éxon 10	Bos taurus taurus	Vaca	IP	Diminuiu	Fedota et al.(²⁸28 Fedota OM, Lysenko NG, Ruban SYu, Kolisnyk OI, Goraychuk IV. The effects of polymorphisms in growth hormone and growth hormone receptor genes on production and reproduction traits in Aberdeen-Angus cattle (Bos taurus L., 1758). Cytology and Genetics. 2017;51(5):352-360. Available from: https://link.springer.com/article/10.3103/S0095452717050024 https://link.springer.com/article/10.310... )

SNP	Região Polimórfica	Subespécie	Novilha/ Vaca	Característica avaliada	Efeito da associação do SNP com a característica avaliada	Referência
IGF-I/SnaBI	Éxon 1	Bos taurus taurus	Vaca	Nº serviços/ gestação;IP; IPC	Manteve	Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )
IGF-I/SnaBI	Região promotora	Bos taurus taurus	Vaca	Nº serviços/ gestação; IPC	Diminuiu	Silveira et al.(²⁹29 Silva Silveira PA, Butler WR, da Silva TC, Barros CC, Corrêa MN, SchneiderA.Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows. Animal reproduction science. 2019;211:106206. Available from: https://pubmed.ncbi.nlm.nih.gov/31785637/ https://pubmed.ncbi.nlm.nih.gov/31785637... )
Transição T→ C	Éxon 4-5	Bos taurus taurus	Novilha	Nº serviços/ gestação; IPP; IP	Manteve	Abdolmohammadi et al. (³⁰30 Abdolmohammadi A, Zamani P. SNP exploring in the middle and terminal regions of the IGF-1 gene and association with production and reproduction traits in Holstein cattle. Gene. 2014;25;540(1):92-5. Available from: https://pubmed.ncbi.nlm.nih.gov/24530703/ https://pubmed.ncbi.nlm.nih.gov/24530703... )
IGF-I rs109763947	Inespecífico	Bos taurus taurus	Vaca	Nº serviços/gestação	Diminuiu	Leyva-Corona et al.(²⁶26 Leyva-Corona JC, Reyna-Granados JR, Zamorano-Algandar R, Sanchez-Castro MA, Thomas MG, EnnsRM, Speidel SE, Medrano JF, Rincon G, Luna-Nevarez P. Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate. Tropical Animal Health and Production. 2018;50, 1913–1920. Available from: https://link.springer.com/article/10.1007/s11250-018-1645-0#citeas https://link.springer.com/article/10.100... )
IGF-I/SnaBI	Região Promotora	Bos taurus taurus	Vaca	IPC	Manteve	Nicolini et al. (³¹31 Nicolini P, Carriquiry M, Meikle A. A polymorphism in the insulin-like growth factor 1 gene is associated with postpartum resumption of ovarian cyclicity in Holstein-Friesian cows under grazing conditions. Acta Veterinaria Scandinavica. 2013;55(1):11. Published 2013 Feb 14. Available from: https://pubmed.ncbi.nlm.nih.gov/23409757/ https://pubmed.ncbi.nlm.nih.gov/23409757... )

SNP	Região Polimórfica	Subespécie	Novilha/ Vaca	Característica avaliada	Efeito da associação do SNP com a característica avaliada	Referência
STAT5A/BstEII	Éxon 8	Bos taurus taurus	Vaca	Nº serviços/ gestação; IP; IPC	Manteve	Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )
STAT5A/BstEII	Éxon 8	Bos taurus taurus	Vaca	Nº serviços/ gestação; IPC	Diminuiu	Silveira et al.(²⁹29 Silva Silveira PA, Butler WR, da Silva TC, Barros CC, Corrêa MN, SchneiderA.Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows. Animal reproduction science. 2019;211:106206. Available from: https://pubmed.ncbi.nlm.nih.gov/31785637/ https://pubmed.ncbi.nlm.nih.gov/31785637... )
SNP12195	Éxon 8	Bos taurus taurus	Novilha	Nº serviços/ gestação; IPP; IPC	Manteve	Oikonomou et al.(³²32 Oikonomou G, Michailidis G, Kougioumtzis A, Avdi M, Banos G. Effect of polymorphisms at the STAT5A and FGF2 gene loci on reproduction, milk yield and lameness of Holstein cows. Research in Veterinary Science. 2011;91(2):235-239. Available from: https://pubmed.ncbi.nlm.nih.gov/21310447/ https://pubmed.ncbi.nlm.nih.gov/21310447... )
SNP12195	Éxon 8	Bos taurus taurus	Vaca	Nº serviços/ gestação; IPC	Manteve	Michel-Regalado et al.(³³33 Michel-Regalado NG, Ayala-Valdovinos MÁ, Galindo-Garcia J, Duifhuis-Rivera T, Sánchez-Chiprés DR, Valencia-Posadas M. Effect of COQ9 and STAT5A polymorphisms on reproductive performance in a Holstein cow herd in Mexico. Animal Reproduction. 2020;17(3): e20200039. Available from: https://www.animal-reproduction.org/article/doi/10.1590/1984-3143-AR2020-0039 https://www.animal-reproduction.org/arti... )

Autor /Ano	SNPs	IPC / dias
Autor /Ano	SNPs	IA	TE	Efeito da associação do SNPcoma característica avaliada
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	GHR/AluI	111	-	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	GHR/AluI	105	-	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	GHR/AluI	112	-	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	GHR/AluI	132	232	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	GHR/AluI	118	231	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	GHR/AluI	133	235	Manteve
Leyva-Corona et al.(²⁶26 Leyva-Corona JC, Reyna-Granados JR, Zamorano-Algandar R, Sanchez-Castro MA, Thomas MG, EnnsRM, Speidel SE, Medrano JF, Rincon G, Luna-Nevarez P. Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate. Tropical Animal Health and Production. 2018;50, 1913–1920. Available from: https://link.springer.com/article/10.1007/s11250-018-1645-0#citeas https://link.springer.com/article/10.100... )	GHR rs41639262	133	-	Diminuiu
Leyva-Corona et al.(²⁶26 Leyva-Corona JC, Reyna-Granados JR, Zamorano-Algandar R, Sanchez-Castro MA, Thomas MG, EnnsRM, Speidel SE, Medrano JF, Rincon G, Luna-Nevarez P. Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate. Tropical Animal Health and Production. 2018;50, 1913–1920. Available from: https://link.springer.com/article/10.1007/s11250-018-1645-0#citeas https://link.springer.com/article/10.100... )	GHR rs41639262	133	-	Diminuiu
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	IGF-I/SnaBI	109	-	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	IGF-I/SnaBI	109	-	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	IGF-I/SnaBI	112	-	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	IGF-I/SnaBI	131	235	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	IGF-I/SnaBI	151	221	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	IGF-I/SnaBI	130	239	Manteve
Silveira et al.3	IGF-I/SnaBI	78	-	Diminuiu
Silveira et al.3	IGF-I/SnaBI	97	-	Diminuiu
Silveira et al.(²⁹29 Silva Silveira PA, Butler WR, da Silva TC, Barros CC, Corrêa MN, SchneiderA.Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows. Animal reproduction science. 2019;211:106206. Available from: https://pubmed.ncbi.nlm.nih.gov/31785637/ https://pubmed.ncbi.nlm.nih.gov/31785637... )	IGF-I/SnaBI	109	-	Diminuiu
Nicolini et al.(³¹31 Nicolini P, Carriquiry M, Meikle A. A polymorphism in the insulin-like growth factor 1 gene is associated with postpartum resumption of ovarian cyclicity in Holstein-Friesian cows under grazing conditions. Acta Veterinaria Scandinavica. 2013;55(1):11. Published 2013 Feb 14. Available from: https://pubmed.ncbi.nlm.nih.gov/23409757/ https://pubmed.ncbi.nlm.nih.gov/23409757... )	IGF-I/SnaBI	91	-	Manteve
Nicolini et al.(³¹31 Nicolini P, Carriquiry M, Meikle A. A polymorphism in the insulin-like growth factor 1 gene is associated with postpartum resumption of ovarian cyclicity in Holstein-Friesian cows under grazing conditions. Acta Veterinaria Scandinavica. 2013;55(1):11. Published 2013 Feb 14. Available from: https://pubmed.ncbi.nlm.nih.gov/23409757/ https://pubmed.ncbi.nlm.nih.gov/23409757... )	IGF-I/SnaBI	92	-	Manteve
Nicolini et al.(³¹31 Nicolini P, Carriquiry M, Meikle A. A polymorphism in the insulin-like growth factor 1 gene is associated with postpartum resumption of ovarian cyclicity in Holstein-Friesian cows under grazing conditions. Acta Veterinaria Scandinavica. 2013;55(1):11. Published 2013 Feb 14. Available from: https://pubmed.ncbi.nlm.nih.gov/23409757/ https://pubmed.ncbi.nlm.nih.gov/23409757... )	IGF-I/SnaBI	87	-	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	STAT5A/BstEII	113	-	Diminuiu
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	STAT5A/BstEII	111	-	Diminuiu
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	STAT5A/BstEII	108	-	Diminuiu
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	STAT5A/B stEII	138	239	Diminuiu
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	STAT5A/BstEII	141	238	Diminuiu
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	STAT5A/BstEII	122	228	Diminuiu
Silveira et al.(²⁹29 Silva Silveira PA, Butler WR, da Silva TC, Barros CC, Corrêa MN, SchneiderA.Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows. Animal reproduction science. 2019;211:106206. Available from: https://pubmed.ncbi.nlm.nih.gov/31785637/ https://pubmed.ncbi.nlm.nih.gov/31785637... )	STAT5A/BstEII	94	-	Diminuiu
Silveira et al.(²⁹29 Silva Silveira PA, Butler WR, da Silva TC, Barros CC, Corrêa MN, SchneiderA.Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows. Animal reproduction science. 2019;211:106206. Available from: https://pubmed.ncbi.nlm.nih.gov/31785637/ https://pubmed.ncbi.nlm.nih.gov/31785637... )	STAT5A/BstEII	102	-	Diminuiu
Silveira et al.(²⁹29 Silva Silveira PA, Butler WR, da Silva TC, Barros CC, Corrêa MN, SchneiderA.Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows. Animal reproduction science. 2019;211:106206. Available from: https://pubmed.ncbi.nlm.nih.gov/31785637/ https://pubmed.ncbi.nlm.nih.gov/31785637... )	STAT5A/BstEII	101	-	Diminuiu
Michel-Regalado et al.(³³33 Michel-Regalado NG, Ayala-Valdovinos MÁ, Galindo-Garcia J, Duifhuis-Rivera T, Sánchez-Chiprés DR, Valencia-Posadas M. Effect of COQ9 and STAT5A polymorphisms on reproductive performance in a Holstein cow herd in Mexico. Animal Reproduction. 2020;17(3): e20200039. Available from: https://www.animal-reproduction.org/article/doi/10.1590/1984-3143-AR2020-0039 https://www.animal-reproduction.org/arti... )	SNP12195	67	-	Manteve
Michel-Regalado et al.(³³33 Michel-Regalado NG, Ayala-Valdovinos MÁ, Galindo-Garcia J, Duifhuis-Rivera T, Sánchez-Chiprés DR, Valencia-Posadas M. Effect of COQ9 and STAT5A polymorphisms on reproductive performance in a Holstein cow herd in Mexico. Animal Reproduction. 2020;17(3): e20200039. Available from: https://www.animal-reproduction.org/article/doi/10.1590/1984-3143-AR2020-0039 https://www.animal-reproduction.org/arti... )	SNP12195	69	-	Manteve
Mi chel-Regalado et al.(³³33 Michel-Regalado NG, Ayala-Valdovinos MÁ, Galindo-Garcia J, Duifhuis-Rivera T, Sánchez-Chiprés DR, Valencia-Posadas M. Effect of COQ9 and STAT5A polymorphisms on reproductive performance in a Holstein cow herd in Mexico. Animal Reproduction. 2020;17(3): e20200039. Available from: https://www.animal-reproduction.org/article/doi/10.1590/1984-3143-AR2020-0039 https://www.animal-reproduction.org/arti... )	SNP12195	74	-	Manteve

Autor / Ano	SNPs	IPP / dias
Abdolmohammadi; Zamani(³⁰30 Abdolmohammadi A, Zamani P. SNP exploring in the middle and terminal regions of the IGF-1 gene and association with production and reproduction traits in Holstein cattle. Gene. 2014;25;540(1):92-5. Available from: https://pubmed.ncbi.nlm.nih.gov/24530703/ https://pubmed.ncbi.nlm.nih.gov/24530703... )	Transição T/C	895,4
Abdolmohammadi; Zamani(³⁰30 Abdolmohammadi A, Zamani P. SNP exploring in the middle and terminal regions of the IGF-1 gene and association with production and reproduction traits in Holstein cattle. Gene. 2014;25;540(1):92-5. Available from: https://pubmed.ncbi.nlm.nih.gov/24530703/ https://pubmed.ncbi.nlm.nih.gov/24530703... )	Transição T/C	889,3
Abdolmohammadi; Zamani(³⁰30 Abdolmohammadi A, Zamani P. SNP exploring in the middle and terminal regions of the IGF-1 gene and association with production and reproduction traits in Holstein cattle. Gene. 2014;25;540(1):92-5. Available from: https://pubmed.ncbi.nlm.nih.gov/24530703/ https://pubmed.ncbi.nlm.nih.gov/24530703... )	Transição T/C	895,4
Abdolmohammadi; Zamani(³⁰30 Abdolmohammadi A, Zamani P. SNP exploring in the middle and terminal regions of the IGF-1 gene and association with production and reproduction traits in Holstein cattle. Gene. 2014;25;540(1):92-5. Available from: https://pubmed.ncbi.nlm.nih.gov/24530703/ https://pubmed.ncbi.nlm.nih.gov/24530703... )	Transição T/C	889,3
Oikonomou et al.(³²32 Oikonomou G, Michailidis G, Kougioumtzis A, Avdi M, Banos G. Effect of polymorphisms at the STAT5A and FGF2 gene loci on reproduction, milk yield and lameness of Holstein cows. Research in Veterinary Science. 2011;91(2):235-239. Available from: https://pubmed.ncbi.nlm.nih.gov/21310447/ https://pubmed.ncbi.nlm.nih.gov/21310447... )	SNP12195	820
Oikonomou et al.(³²32 Oikonomou G, Michailidis G, Kougioumtzis A, Avdi M, Banos G. Effect of polymorphisms at the STAT5A and FGF2 gene loci on reproduction, milk yield and lameness of Holstein cows. Research in Veterinary Science. 2011;91(2):235-239. Available from: https://pubmed.ncbi.nlm.nih.gov/21310447/ https://pubmed.ncbi.nlm.nih.gov/21310447... )	SNP12195	-
Oikonomou et al.(³²32 Oikonomou G, Michailidis G, Kougioumtzis A, Avdi M, Banos G. Effect of polymorphisms at the STAT5A and FGF2 gene loci on reproduction, milk yield and lameness of Holstein cows. Research in Veterinary Science. 2011;91(2):235-239. Available from: https://pubmed.ncbi.nlm.nih.gov/21310447/ https://pubmed.ncbi.nlm.nih.gov/21310447... )	SNP12195	820

Autor / Ano	SNPs	IP / dias	Efeito da associação do SNP com a característica avaliada
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	GHR/Alul	0,65	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	GHR/Alul	0,69	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	GHR/Alul	0,64	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	GHR1.1	0,4	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	GHR1.1	0,4	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	GHR2.6	0,24	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	GHR2.6	0,24	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	GHR4.1	0,19	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	GHR4.1	0,19	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	GHR4.2	0,31	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	GHR4.2	0,31	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	GHR6.1	0,16	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	GHR6.1	0,16	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	GHR9.1	0,42	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	GHR9.1	0,42	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	AF126288:g.149	0,13	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	AF126288:g.149	0,13	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	GHR19.1	0,03	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	GHR19.1	0,03	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	F279Y	0,89	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	F279Y	0,89	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	N528T	0,46	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	N528T	0,46	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	A536T	1,06	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	A536T	1,06	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	H545	0,78	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	H545	0,78	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	S555G	0,54	Manteve
Waters et al.(²⁷27 Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39-49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/ https://pubmed.ncbi.nlm.nih.gov/20528848... )	S555G	0,54	Manteve
Fedota et al.(²⁸28 Fedota OM, Lysenko NG, Ruban SYu, Kolisnyk OI, Goraychuk IV. The effects of polymorphisms in growth hormone and growth hormone receptor genes on production and reproduction traits in Aberdeen-Angus cattle (Bos taurus L., 1758). Cytology and Genetics. 2017;51(5):352-360. Available from: https://link.springer.com/article/10.3103/S0095452717050024 https://link.springer.com/article/10.310... )	g.914T>A	14,3	Diminuiu
Fedota et al.(²⁸28 Fedota OM, Lysenko NG, Ruban SYu, Kolisnyk OI, Goraychuk IV. The effects of polymorphisms in growth hormone and growth hormone receptor genes on production and reproduction traits in Aberdeen-Angus cattle (Bos taurus L., 1758). Cytology and Genetics. 2017;51(5):352-360. Available from: https://link.springer.com/article/10.3103/S0095452717050024 https://link.springer.com/article/10.310... )	g.914T>A	14,5	Diminuiu
Fedota et al.(²⁸28 Fedota OM, Lysenko NG, Ruban SYu, Kolisnyk OI, Goraychuk IV. The effects of polymorphisms in growth hormone and growth hormone receptor genes on production and reproduction traits in Aberdeen-Angus cattle (Bos taurus L., 1758). Cytology and Genetics. 2017;51(5):352-360. Available from: https://link.springer.com/article/10.3103/S0095452717050024 https://link.springer.com/article/10.310... )	g.914T>A	13,6	Diminuiu
Fedota et al.(²⁸28 Fedota OM, Lysenko NG, Ruban SYu, Kolisnyk OI, Goraychuk IV. The effects of polymorphisms in growth hormone and growth hormone receptor genes on production and reproduction traits in Aberdeen-Angus cattle (Bos taurus L., 1758). Cytology and Genetics. 2017;51(5):352-360. Available from: https://link.springer.com/article/10.3103/S0095452717050024 https://link.springer.com/article/10.310... )	g.257A>G	14,1	Diminuiu
Fedota et al.(²⁸28 Fedota OM, Lysenko NG, Ruban SYu, Kolisnyk OI, Goraychuk IV. The effects of polymorphisms in growth hormone and growth hormone receptor genes on production and reproduction traits in Aberdeen-Angus cattle (Bos taurus L., 1758). Cytology and Genetics. 2017;51(5):352-360. Available from: https://link.springer.com/article/10.3103/S0095452717050024 https://link.springer.com/article/10.310... )	g.257A>G	12,7	Diminuiu
Fedota et al.(²⁸28 Fedota OM, Lysenko NG, Ruban SYu, Kolisnyk OI, Goraychuk IV. The effects of polymorphisms in growth hormone and growth hormone receptor genes on production and reproduction traits in Aberdeen-Angus cattle (Bos taurus L., 1758). Cytology and Genetics. 2017;51(5):352-360. Available from: https://link.springer.com/article/10.3103/S0095452717050024 https://link.springer.com/article/10.310... )	g.257A>G	14,7	Diminuiu
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	IGF-I/SnaB1	66,9	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	IGF-I/SnaB1	65,7	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	IGF-I/SnaB 1	64,8	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	STAT5A/BstEII	64	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	STAT5A/BstEII	71	Manteve
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	STAT5A/BstEII	64	Manteve

Autor / Ano	SNPs	Nº Serviçosgestação	Associação
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	GHR/AluI	2,14	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	GHR/AluI	2	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	GHR/AluI	2,25	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	GHR/AluI	2,51	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	GHR/AluI	2,3	Aumentou
Schneider et al.(²⁴24 Schneider A, Corrêa MN, Butler WR. Association between growth hormone receptor AluI polymorphism and fertility of Holstein cows. Theriogenology. 2013;80(9):1061-1066. Available from: https://pubag.nal.usda.gov/catalog/612321 https://pubag.nal.usda.gov/catalog/61232... )	GHR/AluI	2,75	Aumentou
Schneider et al.(²⁴24 Schneider A, Corrêa MN, Butler WR. Association between growth hormone receptor AluI polymorphism and fertility of Holstein cows. Theriogenology. 2013;80(9):1061-1066. Available from: https://pubag.nal.usda.gov/catalog/612321 https://pubag.nal.usda.gov/catalog/61232... )	GHR/AluI	3,4	Aumentou
Schneider et al.(²⁴24 Schneider A, Corrêa MN, Butler WR. Association between growth hormone receptor AluI polymorphism and fertility of Holstein cows. Theriogenology. 2013;80(9):1061-1066. Available from: https://pubag.nal.usda.gov/catalog/612321 https://pubag.nal.usda.gov/catalog/61232... )	GHR/AluI	2,3	Aumentou
Schneider et al.(²⁴24 Schneider A, Corrêa MN, Butler WR. Association between growth hormone receptor AluI polymorphism and fertility of Holstein cows. Theriogenology. 2013;80(9):1061-1066. Available from: https://pubag.nal.usda.gov/catalog/612321 https://pubag.nal.usda.gov/catalog/61232... )	GHR/AluI	2,4	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	IGF-I/SnaBI	2,22	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	IGF-I/SnaBI	2,25	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	IGF-I/SnaBI	2,13	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	IGF-I/SnaBI	3,3	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	IGF-I/SnaBI	3,3	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	IGF-I/SnaBI	2,5	Aumentou
Silveira et al.(²⁹29 Silva Silveira PA, Butler WR, da Silva TC, Barros CC, Corrêa MN, SchneiderA.Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows. Animal reproduction science. 2019;211:106206. Available from: https://pubmed.ncbi.nlm.nih.gov/31785637/ https://pubmed.ncbi.nlm.nih.gov/31785637... )	IGF-I/SnaBI	1,4	Diminuiu
Silveira et al.(²⁹29 Silva Silveira PA, Butler WR, da Silva TC, Barros CC, Corrêa MN, SchneiderA.Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows. Animal reproduction science. 2019;211:106206. Available from: https://pubmed.ncbi.nlm.nih.gov/31785637/ https://pubmed.ncbi.nlm.nih.gov/31785637... )	IGF-I/SnaBI	2,7	Aumentou
Silveira et al.(²⁹29 Silva Silveira PA, Butler WR, da Silva TC, Barros CC, Corrêa MN, SchneiderA.Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows. Animal reproduction science. 2019;211:106206. Available from: https://pubmed.ncbi.nlm.nih.gov/31785637/ https://pubmed.ncbi.nlm.nih.gov/31785637... )	IGF-I/SnaBI	2,8	Aumentou
Abdolmohammadi; Zamani(³⁰30 Abdolmohammadi A, Zamani P. SNP exploring in the middle and terminal regions of the IGF-1 gene and association with production and reproduction traits in Holstein cattle. Gene. 2014;25;540(1):92-5. Available from: https://pubmed.ncbi.nlm.nih.gov/24530703/ https://pubmed.ncbi.nlm.nih.gov/24530703... )	Transição T/C	1,49	Diminuiu
Abdolmohammadi; Zamani(³⁰30 Abdolmohammadi A, Zamani P. SNP exploring in the middle and terminal regions of the IGF-1 gene and association with production and reproduction traits in Holstein cattle. Gene. 2014;25;540(1):92-5. Available from: https://pubmed.ncbi.nlm.nih.gov/24530703/ https://pubmed.ncbi.nlm.nih.gov/24530703... )	Transição T/C	1,35	Diminuiu
Abdolmohammadi; Zamani(³⁰30 Abdolmohammadi A, Zamani P. SNP exploring in the middle and terminal regions of the IGF-1 gene and association with production and reproduction traits in Holstein cattle. Gene. 2014;25;540(1):92-5. Available from: https://pubmed.ncbi.nlm.nih.gov/24530703/ https://pubmed.ncbi.nlm.nih.gov/24530703... )	Transição T/C	3,11	Aumentou
Abdolmohammadi; Zamani(³⁰30 Abdolmohammadi A, Zamani P. SNP exploring in the middle and terminal regions of the IGF-1 gene and association with production and reproduction traits in Holstein cattle. Gene. 2014;25;540(1):92-5. Available from: https://pubmed.ncbi.nlm.nih.gov/24530703/ https://pubmed.ncbi.nlm.nih.gov/24530703... )	Transição T/C	2,82	Aumentou
Leyva-Corona et al.(²⁶26 Leyva-Corona JC, Reyna-Granados JR, Zamorano-Algandar R, Sanchez-Castro MA, Thomas MG, EnnsRM, Speidel SE, Medrano JF, Rincon G, Luna-Nevarez P. Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate. Tropical Animal Health and Production. 2018;50, 1913–1920. Available from: https://link.springer.com/article/10.1007/s11250-018-1645-0#citeas https://link.springer.com/article/10.100... )	IGF-I rs 109763947	1,9	Aumentou
Leyva-Corona et al.(²⁶26 Leyva-Corona JC, Reyna-Granados JR, Zamorano-Algandar R, Sanchez-Castro MA, Thomas MG, EnnsRM, Speidel SE, Medrano JF, Rincon G, Luna-Nevarez P. Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate. Tropical Animal Health and Production. 2018;50, 1913–1920. Available from: https://link.springer.com/article/10.1007/s11250-018-1645-0#citeas https://link.springer.com/article/10.100... )	IGF-I rs 109763947	0	-
Leyva-Corona et al.(²⁶26 Leyva-Corona JC, Reyna-Granados JR, Zamorano-Algandar R, Sanchez-Castro MA, Thomas MG, EnnsRM, Speidel SE, Medrano JF, Rincon G, Luna-Nevarez P. Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate. Tropical Animal Health and Production. 2018;50, 1913–1920. Available from: https://link.springer.com/article/10.1007/s11250-018-1645-0#citeas https://link.springer.com/article/10.100... )	IGF-I rs 109763947	1,9	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	STAT5A/BstEII	2,16	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	STAT5A/BstEII	2,24	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	STAT5A/BstEII	2,18	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	STAT5A/BstEII	2,7	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	STAT5A/BstEII	2,8	Aumentou
Hax et al.(²⁵25 Hax LT, SchneiderA, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267 https://pubag.nal.usda.gov/catalog/52522... )	STAT5A/BstEII	2,4	Aumentou
Silveira et al.(²⁹29 Silva Silveira PA, Butler WR, da Silva TC, Barros CC, Corrêa MN, SchneiderA.Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows. Animal reproduction science. 2019;211:106206. Available from: https://pubmed.ncbi.nlm.nih.gov/31785637/ https://pubmed.ncbi.nlm.nih.gov/31785637... )	STAT5A/BstEII	2,6	Aumentou
Silveira et al.(²⁹29 Silva Silveira PA, Butler WR, da Silva TC, Barros CC, Corrêa MN, SchneiderA.Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows. Animal reproduction science. 2019;211:106206. Available from: https://pubmed.ncbi.nlm.nih.gov/31785637/ https://pubmed.ncbi.nlm.nih.gov/31785637... )	STAT5A/BstEII	2,6	Aumentou
Silveira et al.(²⁹29 Silva Silveira PA, Butler WR, da Silva TC, Barros CC, Corrêa MN, SchneiderA.Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows. Animal reproduction science. 2019;211:106206. Available from: https://pubmed.ncbi.nlm.nih.gov/31785637/ https://pubmed.ncbi.nlm.nih.gov/31785637... )	STAT5A/BstEII	2,5	Aumentou
Oikonomou et al.(³²32 Oikonomou G, Michailidis G, Kougioumtzis A, Avdi M, Banos G. Effect of polymorphisms at the STAT5A and FGF2 gene loci on reproduction, milk yield and lameness of Holstein cows. Research in Veterinary Science. 2011;91(2):235-239. Available from: https://pubmed.ncbi.nlm.nih.gov/21310447/ https://pubmed.ncbi.nlm.nih.gov/21310447... )	SNP12195	0	-
Oikonomou et al.(³²32 Oikonomou G, Michailidis G, Kougioumtzis A, Avdi M, Banos G. Effect of polymorphisms at the STAT5A and FGF2 gene loci on reproduction, milk yield and lameness of Holstein cows. Research in Veterinary Science. 2011;91(2):235-239. Available from: https://pubmed.ncbi.nlm.nih.gov/21310447/ https://pubmed.ncbi.nlm.nih.gov/21310447... )	SNP12195	0	-
Oikonomou et al.(³²32 Oikonomou G, Michailidis G, Kougioumtzis A, Avdi M, Banos G. Effect of polymorphisms at the STAT5A and FGF2 gene loci on reproduction, milk yield and lameness of Holstein cows. Research in Veterinary Science. 2011;91(2):235-239. Available from: https://pubmed.ncbi.nlm.nih.gov/21310447/ https://pubmed.ncbi.nlm.nih.gov/21310447... )	SNP12195	0	-
Michel-Regalado et al.(³³33 Michel-Regalado NG, Ayala-Valdovinos MÁ, Galindo-Garcia J, Duifhuis-Rivera T, Sánchez-Chiprés DR, Valencia-Posadas M. Effect of COQ9 and STAT5A polymorphisms on reproductive performance in a Holstein cow herd in Mexico. Animal Reproduction. 2020;17(3): e20200039. Available from: https://www.animal-reproduction.org/article/doi/10.1590/1984-3143-AR2020-0039 https://www.animal-reproduction.org/arti... )	SNP12195	3,1	Aumentou
Michel-Regalado et al.(³³33 Michel-Regalado NG, Ayala-Valdovinos MÁ, Galindo-Garcia J, Duifhuis-Rivera T, Sánchez-Chiprés DR, Valencia-Posadas M. Effect of COQ9 and STAT5A polymorphisms on reproductive performance in a Holstein cow herd in Mexico. Animal Reproduction. 2020;17(3): e20200039. Available from: https://www.animal-reproduction.org/article/doi/10.1590/1984-3143-AR2020-0039 https://www.animal-reproduction.org/arti... )	SNP12195	2,8	Aumentou
Michel-Regalado et al.(³³33 Michel-Regalado NG, Ayala-Valdovinos MÁ, Galindo-Garcia J, Duifhuis-Rivera T, Sánchez-Chiprés DR, Valencia-Posadas M. Effect of COQ9 and STAT5A polymorphisms on reproductive performance in a Holstein cow herd in Mexico. Animal Reproduction. 2020;17(3): e20200039. Available from: https://www.animal-reproduction.org/article/doi/10.1590/1984-3143-AR2020-0039 https://www.animal-reproduction.org/arti... )	SNP12195	3,3	Aumentou

[1] *Correspondente: nunes.mdnunes@gmail.com

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Associação entre polimorfismos de genes do eixo somatotrópico e eficiência reprodutiva de fêmeas bovinas: revisão de literatura

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