Arq Neuropsiquiatr. 2019;77(7):509-520
Consensus of the Brazilian Headache Society on the treatment of chronic migraine
DOI: http://dx.doi.org/10.1590/0004-282x20190078
The table 5:
Table 5 Oral drugs evaluated in the treatment of chronic migraine in adults: evidence of efficacy, class of recommendation, recommended doses and risk categories regarding use during pregnancy and lactation.
| Drug | Evidence | Recommendation | Dose (mg/day) | Risk during pregnancy* | Risk during lactation** † | References |
|---|---|---|---|---|---|---|
| Neuromodulators | ||||||
| Topiramate | I | A | 50-200 | D | L3 | 62, 64-66, 70 |
| Valproate | II | B | 500-2000 | X | L2 | 71 |
| Gabapentin | II | B | 900-1800 | C | L2 | 72 |
| Pregabalin | III | C | 125-450 | C | L2 | 73 |
| Zonisamide | III | C | 50-200 | D | L5 | 74 |
| Beta-blockers | ||||||
| Atenolol | III | C | 50-200 | C | L3 | 75 |
| Tricyclics | ||||||
| Amitriptyline | II | C | 50-100 | C | L2 | 76 |
| Calcium channel blockers | ||||||
| Flunarizine | III | C | 10 | C | L5 | 77 |
| Miscellaneous | ||||||
| Tizanidine | II | B | fev/24 | C | L3 | 78 |
Should be:
Table 5 Oral drugs evaluated in the treatment of chronic migraine in adults: evidence of efficacy, class of recommendation, recommended doses and risk categories regarding use during pregnancy and lactation.
| Drug | Evidence | Recommendation | Dose (mg/day) | Risk during pregnancy* | Risk during lactation** † | References |
|---|---|---|---|---|---|---|
| Neuromodulators | ||||||
| Topiramate | I | A | 50-200 | D | L3 | 62, 64-66, 70 |
| Valproate | II | B | 500-2000 | X | L2 | 71 |
| Gabapentin | II | B | 900-1800 | C | L2 | 72 |
| Pregabalin | III | C | 125-450 | C | L2 | 73 |
| Zonisamide | III | C | 50-200 | D | L5 | 74 |
| Beta-blockers | ||||||
| Atenolol | III | C | 50-200 | C | L3 | 75 |
| Tricyclics | ||||||
| Amitriptyline | II | C | 50-100 | C | L2 | 76 |
| Calcium channel blockers | ||||||
| Flunarizine | III | C | 10 | C | L5 | 77 |
| Miscellaneous | ||||||
| Tizanidine | II | B | 2-24 | C | L3 | 78 |
Publication Dates
-
Publication in this collection
24 Oct 2019 -
Date of issue
Oct 2019
