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Synthesis of imidazole derivatives from β-lapachone and related compounds using microwave and supported reagents

New naphthoimidazoles were prepared by reaction, activated by microwave irradiation, between paraformaldehyde, β-lapachone (or related o-quinones) and ammonium acetate supported on montmorillonite k-10, or on basic alumina. Use of the basic support gave the best results, with yields above 80%. This was confirmed for the reaction with β-lapachone and piperonal.

imidazole; microwave; basic alumina; lapachone


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