| | Table of contents
Mem. Inst. Oswaldo Cruz vol.117 Rio de Janeiro 2022  Press Release | | | | |
| Editorial | | | | | | · Molecular mechanisms of action of trypanocidal and leishmanicidal drugs with focus on novel chemotherapeutic strategies: creation of a Brazilian multicentre working group
Menna-Barreto, Rubem Figueiredo Sadok; dos Santos, André Luis Souza
| | | | | Review | | | | | | · Significance of a neglected tropical disease: lessons from a paradigmatic case of ‘success in translation’
Morel, Carlos M
| | | | | | · Trypanosoma cruzi genetic diversity: impact on transmission cycles and Chagas disease
Zingales, Bianca; Bartholomeu, Daniella C
| | | | | | · Why do we still have not a vaccine against Chagas disease?
Camargo, Erney Plessmann; Gazzinelli, Ricardo Tostes; Morel, Carlos Médicis; Precioso, Alexander Roberto
| | | | | | · Emerging and reemerging forms of Trypanosoma cruzi transmission
Shikanai Yasuda, Maria Aparecida
| | | | | | · The history of Chagas disease: reflections on science in action
Kropf, Simone Petraglia; Lima, Nísia Trindade
| | | | | | · Different profiles and epidemiological scenarios: past, present and future
Gorla, David E; Xiao-Nong, Zhou; Diotaiuti, Lileia; Khoa, Pham Thi; Waleckx, Etienne; Souza, Rita de Cássia Moreira de; Qin, Liu; Lam, Truong Xuan; Freilij, Hector
| | | | | | · The translational challenge in Chagas disease drug development
Kratz, Jadel M; Gonçalves, Karolina R; Romera, Lavínia MD; Moraes, Carolina Borsoi; Bittencourt-Cunha, Paula; Schenkman, Sergio; Chatelain, Eric; Sosa-Estani, Sergio
| | | | | | · Parasitological, serological and molecular diagnosis of acute and chronic Chagas disease: from field to laboratory
Schijman, Alejandro Gabriel; Alonso-Padilla, Julio; Longhi, Silvia Andrea; Picado, Albert
| | | | | | · Chagas disease in the context of the 2030 agenda: global warming and vectors
Souza, Rita de Cássia Moreira de; Gorla, David E; Chame, Marcia; Jaramillo, Nicolas; Monroy, Carlota; Diotaiuti, Lileia
| | | | | | · The multidimensional comprehension of Chagas disease. Contributions, approaches, challenges and opportunities from and beyond the Information, Education and Communication field
Sanmartino, Mariana; Forsyth, Colin J; Avaria, Andrea; Velarde-Rodriguez, Mar; Gómez i Prat, Jordi; Albajar-Viñas, Pedro
| | | | | | · Prognosis of chronic Chagas heart disease and other pending clinical challenges
Torres, Rosália Morais; Correia, Dalmo; Nunes, Maria do Carmo Pereira; Dutra, Walderez O; Talvani, André; Sousa, Andréa Silvestre; Mendes, Fernanda de Souza Nogueira Sardinha; Scanavacca, Maurício Ibrahim; Pisani, Cristiano; Moreira, Maria da Consolação Vieira; de Souza, Dilma do Socorro Moraes; de Oliveira Junior, Wilson; Martins, Silvia Marinho; Dias, João Carlos Pinto
| | | | | Perspectives | | | | | | · Is the mitochondrion a promising drug target in trypanosomatids?
Pedra-Rezende, Yasmin; Bombaça, Ana Cristina Souza; Menna-Barreto, Rubem Figueiredo Sadok
| | | | | | · Transforming growth factor-ß as a therapeutic target for the cardiac damage of Chagas disease
Waghabi, Mariana Caldas; Ferreira, Roberto Rodrigues; Abreu, Rayane da Silva; Degrave, Wim; de Souza, Elen Mello; Bailly, Sabine; Feige, Jean-Jacques; de Araújo-Jorge, Tania C
| | | | | | · Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy
Santi, Ana Maria Murta; Murta, Silvane Maria Fonseca
| | | | | | · Past and future of trypanosomatids high-throughput phenotypic screening
Dantas, Rafael Ferreira; Torres-Santos, Eduardo Caio; Silva Jr, Floriano Paes
| | | | | | · Computational approaches towards the discovery and optimisation of cruzain inhibitors
Santos, Viviane Corrêa; Ferreira, Rafaela Salgado
| | | | | | · Repositioning drug strategy against Trypanosoma cruzi: lessons learned from HIV aspartyl peptidase inhibitors
Sangenito, Leandro Stefano; d’Avila-Levy, Claudia Masini; Branquinha, Marta Helena; Santos, André Luis Souza dos
| | | | | | · Perspectives for a new drug candidate for Chagas disease therapy
Soeiro, Maria de Nazaré Correia
| | | | | | · Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress
Monte Neto, Rubens Lima do; Moreira, Paulo Otávio Lourenço; de Sousa, Alessandra Mara; Garcia, Miguel Antonio do Nascimento; Maran, Suellen Rodrigues; Moretti, Nilmar Silvio
| | | | | | · Translational research in Chagas disease: perspectives in nutritional therapy emerging from selenium supplementation studies as a complementary treatment
Araujo-Jorge, Tania C de; Ferreira, Roberto R
| | | | | | · Multi-therapeutic strategy targeting parasite and inflammation-related alterations to improve prognosis of chronic Chagas cardiomyopathy: a hypothesis-based approach*
Lannes-Vieira, Joseli
| | | | | | · Proteolytic inhibitors as alternative medicines to treat trypanosomatid-caused diseases: experience with calpain inhibitors
Ennes-Vidal, Vítor; dos Santos, André Luis Souza; Branquinha, Marta Helena; d’Avila-Levy, Claudia Masini
| | | | | | · Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: mitochondrion as a strategic target
Lazarin-Bidóia, Danielle; Garcia, Francielle Pelegrin; Ueda-Nakamura, Tânia; Silva, Sueli de Oliveira; Nakamura, Celso Vataru
| | | | | | · Host cholesterol influences the activity of sterol biosynthesis inhibitors in Leishmania amazonensis
Andrade-Neto, Valter Viana; Manso, Pedro Paulo de Abreu; Pereira, Miria Gomes; de Cicco, Nuccia Nicole Theodoro; Atella, Georgia Corrêa; Pelajo-Machado, Marcelo; Menna-Barreto, Rubem Figueiredo Sadok; Torres-Santos, Eduardo Caio
| | | | | | · Article-processing charges as a barrier for science in low-to-medium income regions
Rodrigues, Marcio L; Savino, Wilson; Goldenberg, Samuel
| | | | | Research Article | | | | | | · Mapping Yellow fever epidemics as a potential indicator of the historical range of Aedes aegypti in the United States
Fijman, Nicole S; Yee, Donald A
| | | | | | · Accuracy of rapid point-of-care serological tests for leprosy diagnosis: a systematic review and meta-analysis
Romero, Carmen Phang; Castro, Rodolfo; do Brasil, Pedro Emmanuel A; Pereira, Daniella R; Pinheiro, Roberta Olmo; Toscano, Cristiana M; de Oliveira, Maria Regina Fernandes
| | | | | | · Callitrichine gammaherpesvirus 3 and Human alphaherpesvirus 1 in New World Primate negative for yellow fever virus in Rio de Janeiro, Brazil
Bonfim, Flávia Freitas de Oliveira; Mares-Guia, Maria Angélica Monteiro de Mello; Horta, Marco Aurélio; Chame, Marcia; Lopes, Amanda de Oliveira; Santos, Rafael; Matias, Carlos Alexandre Rey; Pinto, Marcelo Alves; de Filippis, Ana Maria Bispo; de Paula, Vanessa Salete
| | | | | | · Molecular aspects of Chikungunya virus infections in cancer patients
Familiar-Macedo, Débora; Gama, Bianca Ervatti; Emmel, Vanessa Erichsen; Vera-Lozada, Gabriela; Abdelhay, Eliana; Martins, Ianick Souto; Hassan, Rocio
| | | | | | · Homozygotes NAT2*5B slow acetylators are highly associated with hepatotoxicity induced by anti-tuberculosis drugs
El-Jaick, Kenia Balbi; Ribeiro-Alves, Marcelo; Soares, Marcos Vinícius Guimarães; Araujo, Gabriela Eduardo França de; Pereira, Gabriel Rodrigues Coutinho; Rolla, Valeria Cavalcanti; Mesquita, Joelma Freire De; De Castro, Liane
| | | | | | · Mitochondrial dysfunction on Leishmania (Leishmania) amazonensis induced by ketoconazole: insights into drug mode of action
Nunes, Débora Cristina de Oliveira Silva; Costa, Mônica Soares; Bispo-da-Silva, Luiz Borges; Ferro, Eloísa Amália Vieira; Zóia, Mariana Alves Pereira; Goulart, Luiz Ricardo; Rodrigues, Renata Santos; Rodrigues, Veridiana de Melo; Yoneyama, Kelly Aparecida Geraldo
| | | | | | · First report and genome sequencing of SARS-CoV-2 in a cat (Felis catus) in Colombia
Botero, Yesica; Ramírez, Juan David; Serrano-Coll, Héctor; Aleman, Ader; Ballesteros, Nathalia; Martinez, Caty; Muñoz, Marina; Calderon, Alfonso; Patiño, Luz H; Guzman, Camilo; Castañeda, Sergio; Hererra, Yonairo; Mattar, Salim
| | | | | | · Association of CD209 (DC-SIGN) rs735240 SNV with paucibacillary leprosy in the Brazilian population and its functional effects
Germano, Giovanna Valle; Braga, André Flores; Camargo, Rodrigo Mendes de; Ballalai, Priscila Betoni; Bezerra, Ohanna Cavalcanti; Manta, Fernanda Saloum de Neves; Belone, Andréa de Faria Fernandes; Soares, Cleverson Teixeira; Das, Pranab Kumar; Moraes, Milton Ozório; Latini, Ana Carla Pereira; Brito de Souza, Vânia Niéto
| | | | | | · The scientific publication of the Memórias do Instituto Oswaldo Cruz (1909-2020): a history of contribution to the biomedical sciences
Mota, Fabio Batista; Braga, Luiza Amara Maciel; Cabral, Bernardo Pereira; Lopes, Renato Matos; Alves, Luiz Anastácio
| | | | | | · CCR6 expression reduces mouse survival upon malarial challenge with Plasmodium berghei NK65 strain
Silveira, Eduardo Lani Volpe da; Rai, Urvashi; Bonezi, Vivian; Zárate-Bladés, Carlos Rodrigo; Claser, Carla
| | | | | | · Binding of the extracellular matrix laminin-1 to Clostridioides difficile strains
Santos, Mayara Gil de Castro; Trindade, Camilla Nunes dos Reis; Vommaro, Rossiane Cláudia; Domingues, Regina Maria Calvalcanti Pilotto; Ferreira, Eliane de Oliveira
| | | | | | · Molecular detection of omicron SARS-CoV-2 variant is achieved by RT-LAMP despite genomic mutations
Almeida, Letícia Trindade; Gonçalves, Amanda Bonoto; Franco-Luiz, Ana Paula Moreira; Silva, Thais Bárbara de Souza; Alves, Pedro Augusto; Monte-Neto, Rubens Lima do
| | | | | | · Prevalence and force of Plasmodium vivax blood-stage infection and associated clinical malaria burden in the Brazilian Amazon
Monteiro, Wuelton; Karl, Stephan; Kuehn, Andrea; Almeida, Anne; White, Michael; Vitor-Silva, Sheila; Melo, Gisely; Brito-Sousa, Jose Diego; Baia-da-Silva, Djane Clarys; Silva-Neto, Alexandre Vilhena; Sampaio, Vanderson; Bassat, Quique; Felger, Ingrid; Mueller, Ivo; Lacerda, Marcus
| | | | | | · Chagas disease affects the human placental barrier’s turnover dynamics during pregnancy
Mezzano, Luciana; Morán, Joana Paola; Moreira-Espinoza, María José; Triquell, María Fernanda; Mezzano, Julieta; Díaz-Luján, Cintia María; Fretes, Ricardo Emilio
| | | | | | · Toxoplasma gondii in the faeces of wild felids from the Atlantic Forest, Brazil
Bolais, Paula F; Galal, Lokman; Cronemberger, Cecília; Pereira, Fabiane de Aguiar; Barbosa, Alynne da Silva; Dib, Laís Verdan; Amendoeira, Maria Regina Reis; Dardé, Marie-Laure; Mercier, Aurélien
| | | | | Article Commentary | | | | | | · Morel paper is a passionate plea for the concept of “translation” with translational research (TR) as a flag
Jannin, Jean
| | | | | | · Waiting for a success story in prevention, control and treatment of Chagas disease in non-endemic countries
Bartoloni, Alessandro
| | | | | | · Peeking into the mysterious world of Trypanosoma cruzi and Chagas disease
Macedo, Andréa M; Pena, Sérgio DJ
| | | | | | · Trypanosoma cruzi and Chagas disease: diversity, progress and challenges
Miles, Michael A
| | | | | | · A safe, effective, and reliable vaccine against Chagas disease should be described!
Silva, João S
| | | | | | · Brazilian immunology in Caxambu: beyond vaccination, a tribute to the pioneers of basic research in Chagas disease
Scharfstein, Julio
| | | | | | · The challenges for targeting Chagas disease for elimination as a public health problem
Werneck, Guilherme Loureiro
| | | | | | · Chagas disease challenge - New techniques for diagnosis and treatment address to control in endemic areas
Marins, José Ricardo Pio
| | | | | | · Chagas disease and its historicity
Gomes, Ana Carolina Vimieiro
| | | | | | · A note on the the discovery of Chagas' disease
de Avila-Pires, Fernando Dias
| | | | | | · Reflections on Chagas disease in the Amazon
Aguilar, V H Marcelo
| | | | | | · Challenges for fighting Chagas disease in the 21st century
Freitas, Laís Picinini; Lana, Raquel Martins; Cruz, Oswaldo Gonçalves
| | | | | | · Chagas disease treatment: a 120-year-old challenge to public health
Goldenberg, Samuel
| | | | | | · Comment on “The translational challenge in Chagas disease drug development” by Kratz et al.
De Rycker, Manu
| | | | | | · Air in the tires: towards an achievable, efficacious and timely diagnosis for Chagas disease
Angheben, Andrea
| | | | | | · Revisiting Chagas' disease diagnostic strategies in light of different scenarios of Trypanosoma cruzi infection
Britto, Constança Carvalho
| | | | | | · How is global change affecting Chagas disease landscapes?
Gürtler, Ricardo E
| | | | | | · Chagas disease (American trypanosomiasis) in the context of the 2030 agenda. Insights into global warming and vector control
Jurberg, José
| | | | | | · Reflections how IEC can empower and integrate stakeholders to denormalise Chagas disease and drive care and prevention policy: healthcare system governance at the heart of Chagas disease neglect
Ramsey, Janine M
| | | | | | · Reflections, suggestions for putting into practice the principles of information, education and communication - IEC on Chagas disease in a community context
Anselmi, Mariella
| | | | | | · Pathophysiology and new targets for therapeutic options in Chagas heart disease
Ferreira, João Marcos B Barbosa
| | | | | | · The challenge of risk assessment in the riddle of Chagas heart disease
Marin-Neto, José Antonio; Rassi Jr, Anis
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