EEG-EKG, or when 1 + 1 is more than 2

EEG-EKG o cuando 1 + 1 es más que 2

Although the principles of human electrophysiology were set up by the end of the XIX century, the recording of electrophysiological signals for diagnostic purposes started some decades later. In 1924, Hans Berger discovered the electroencephalography (EEG), while Einthoven was being recognized with the Nobel Prize for the development of the electrocardiogram (EKG). Capturing and recording the spontaneous electrical activity of the cerebral cortex noninvasively from the surface with skin electrodes was developed and widely used thereafter, being epilepsy diagnosis its most frequent application, particularly after the pioneer works of Gibbs & Gibbs.

The inclusion of basic, 2-lead EKG recording in routine EEG studies was initially devoted to help identify some spiky artifacts due to the capture of cardiac signals by cranial electrodes. Gradually, the value of analyzing the covariation of both signals and their clinical correlates aroused the interest of the community of both clinicians and researchers. A sudden and significant increase in the heart rate (HR) during an ictal episode was reported to correlate with an epileptic versus psychogenic nature¹, while the lateralizing value of ictal tachycardia or bradycardia has never been fully demonstrated^2,3.

More recently⁴, ictal bradycardia and asystole have been described in a subset of refractory epilepsy patients, where the recruitment of autonomic networks by the propagating epileptic discharge stops the heart, and the consequent hemodynamic fall shuts down the seizing activity, finally relieving the central autonomic nervous system from its harmful influence and, in most cases, regaining normal cardiac activity and then, consciousness. This phenomenon, diagnosed on the basis of a simple ictal EEG-EKG co-registration, allows for both new diagnostic and therapeutic decisions.

Finally, understanding the covariation and mutual influence of brain and heart activity regained a prominent position in epilepsy research in the context of sudden unexpected death in epilepsy (SUDEP), an increasingly recognized entity.

Technological advances, from a higher number of recording channels in the EEG equipment to digitalization and post-processing software, were hallmarks in the evolution of multimodal recordings. As the awareness of new challenges to be faced is developed, simple, “old” tools should not be forgotten; it may just be the place for one’s ability to pose the proper questions and to review their own beliefs, which may lead to new answers and solutions.

In the following article⁵, the additional relevance of a multidisciplinary approach is highlighted, in this case through a more systematic analysis of EKG derived from the interictal simultaneous EEG-EKG recording in epilepsy patients.

References

• ¹
  Opherk C, Hirsch LJ. Ictal heart rate differentiates epileptic from non-epileptic seizures. Neurology. 2002 Feb;58(4):636-8. https://doi.org/10.1212/wnl.58.4.636
  » https://doi.org/https://doi.org/10.1212/wnl.58.4.636
• ²
  Garcia M, D'Giano C, Estellés S, Leiguarda R, Rabinowicz A. Ictal tachycardia: its discriminating potential between temporal and extratemporal seizure foci. Seizure. 2001 Sep;10(6):415-9. https://doi.org/10.1053/seiz.2000.0529
  » https://doi.org/https://doi.org/10.1053/seiz.2000.0529
• ³
  Britton JW, Ghearing GR, Benarroch EE, Cascino GD. The ictal bradycardia syndrome: localization and lateralization. Epilepsia. 2006 Apr;47(4):737-44. https://doi.org/10.1111/j.1528-1167.2006.00509.x
  » https://doi.org/https://doi.org/10.1111/j.1528-1167.2006.00509.x
• ⁴
  Tényi D, Gyimesi C, Kupó P, Horváth R, Bóné B, Barsi P, et al. Ictal asystole: a systematic review. Epilepsia. 2017 Mar;58(3):356-62. https://doi.org/10.1111/epi.13644
  » https://doi.org/https://doi.org/10.1111/epi.13644
• ⁵
  Onder H, Tezer I, Hekimsoy V, Saygi S. Simultaneous electrocardiogram during routine electroencephalogram: arrhythmia rates through the eyes of the cardiologist. Arq Neuro-Psiquiatr. 2020. In Press.

Publication Dates

• Publication in this collection
  26 Feb 2021
• Date of issue
  Jan 2021

History

• Received
  23 Nov 2020
• Reviewed
  08 Dec 2020
• Accepted
  09 Dec 2020