Olfactory groove meningioma: correlation between tumoral volume, edena volume, proliferative index and vascular endothelial growth factor

THESES

Olfactory groove meningioma: correlation between tumoral volume, edena volume, proliferative index and vascular endothelial growth factor (Abstract)^*. Thesis. São Paulo, 2005

Manoel Antonio de Paiva Neto^**

OBJECTIVE: The aim of this study is to correlatte demografic (sex and age), radiologic features (tumoral and edema volumes, frontal skullbase invasion) and imunohistochemical expression of Mib-1 and vascular endothelial growth factor (VEGF).

METHOD: There were analysed demografic and radiological features of 22 patients with olfactory groove meningioma. Fifteen paraffin-embebed tumors were studied by imunohistochemical methods for the expression of vascular endothelial growth factor and proliferative index by the Mib-1. Statistical program was used to correlationate demografic and radiological features with the proliferative index and vascular endothelial growth factor expression.

RESULTS: There was a statiscally positive correlation between tumoral and edema volumes. The tumoral and edema volumes were significantly larger in the male sex. There was no correlation betweem Mib-1 , tumoral volume, tumoral edema and frontal skullbase abnormalities. The tumoral volume and the edema volume were larger in patients with vascular endothelial growth factor expression. Two cases with tumor recurrence had proliferative indices higher than the mean index of this study, and hyperostosis of the frontal skullbase.

CONCLUSION: Larger tumors were more susceptible to develop peritumoral edema, also the male gender. The proliferative índex has no correlation with tumoral and edema volumes, but probably it is associated with tumoral recurrence. Vascular endothelial growth factor expression is a important factor in edema formation and growth of this tumors.

Key words: meningioma, olfactory groove, proliferative index, vascular endothelial grwth factor, edema.

*

Meningeoma de goteira olfatória: relação entre volume tumoral, volume de edema, índice proliferativo celular e fator de crescimento endotelial vascular (Resumo). Tese de Mestrado, Universidade Federal de São Paulo – Escola Paulista de Medicina (Área: Neurocirurgia). Orientador: Oswaldo Inácio de Tella Jr.

**

Address: Rua Loefgreen 1654 / 44, 04040-002 São Paulo SP, Brasil.

Publication Dates

• Publication in this collection
  02 Mar 2006
• Date of issue
  Sept 2005