THESES
Peripheral neuropathy investigation in the early stage of bone marrow transplantation (abstract)* * Dissertação de Mestrado, Universidade Federal do Paraná (Área: Neurologia). Orientador: Lineu César Werneck. ** Address: Avenida Sete de Setembro 4512 apto 91, 80250-210 Curitiba PR, Brasil. Fax 041 244 7991. E-mail: viviane@avalon.com.sul.br
Investigação de neuropatia periférica durante o período recente do transplante de medula óssea (Resumo)
Viviane de Hiroki Flumignan Zétola** * Dissertação de Mestrado, Universidade Federal do Paraná (Área: Neurologia). Orientador: Lineu César Werneck. ** Address: Avenida Sete de Setembro 4512 apto 91, 80250-210 Curitiba PR, Brasil. Fax 041 244 7991. E-mail: viviane@avalon.com.sul.br
Peripheral neuropathy investigation in the early stage of bone marrow transplantation (abstract). Thesis. Curitiba, 1997
Over the last decade, bone marrow transplantation (BMT) has developed into an important treatment method for aplastic anemia and a variety of hematologic and lympho-reticular diseases, solid malignancies, inborn errors of metabolism and deficiency diseases. Unfortunately, the procedure carries a significant risk for neurological complications (59-79%). The peripheral nerve complications, however, are rare and may be secondary to the therapy to avoid rejection. At any rate, it has been postulated that early diagnosis of such complications may lead to drug adjustments or a complete change in the therapeutic scheme. This particular scenario was analysed in patients who were submitted to BMT in order to verify whether the drugs used in the early stage of BMT could induce peripheral neuropathy.
Forty-three patients with several hematological diseases in the early stage of BMT were prospectively studied. All patients underwent a complete neurological examination, vibratory sense perception test, and nerve conduction study both before and after BMT (admission time: approximately 90 days). The following nerves were studied: median, peroneal, posterior tibial (motor), median and sural (sensitive). The nerve conduction study included latency, amplitude and duration, as well as both compound muscle action and sensory nerve action potential, plus nerve conduction velocity. Most patients were in busulphan, cyclophosphamide, cyclosporine A and methotrexate. Serum levels of creatine kinase, creatinine, albumin and glucose were analysed.
Ages varied from 12 to 52 (mean 28.58 years old); 34.9% were female and 65.1 % male patients. The mean disease duration time was 1.33 years. Although the results showed statistical differences between glucose and albumin serum levels, plus non-specific abnormalities in the nerve conduction study, all of these differences were not sufficient to induce or diagnose peripheral nerve injury. Therefore, it was concluded that peripheral neuropathy does not occur in the early stage of BMT in our hospital.
Key words: peripheral neuropathy, nerve conduction study, bone marrow transplantation.
Publication Dates
-
Publication in this collection
18 Oct 2010 -
Date of issue
Sept 1997
