Polineuropatia devida ao óxido de etileno registro de caso com estudo clínico, eletrofisiológico e histopatológico

Freitas, Marcos R. G. de; Nascimento, Osvaldo J. M.; Chimelli, Leila

doi:10.1590/S0004-282X1991000400017

Resumos

Os autores referem-se a caso de um jovem que, trabalhando em fábrica de esterilização de artigos médicos e em contato diário com o óxido de etileno, desenvolveu leve polineuropatia sensitivo-motora. Os estudos eletrofisiológicos evidenciaram neuropatia por degeneração axonal. A biópsia do nervo sural mostrou discreta perda de fibras mielínicas e sinais de degeneração e regeneração axonal. Este é o primeiro caso desta afecção descrita em nosso meio.

A man who worked as an operator in a factory of sterilization of heat-sen-sitive materials has been exposed to ethylene oxide for seven years. He developed a mild sensori-motor polyneuropathy. The electromyography and nerve conduction studies showed an axonal degenerative type of neuropathy. The sural nerve biopsy revealed mild loss of myelinated fibers, some fibers with axonial degeneration, some clusters of regeneration and few rows of myelin ovoids in the teased nerve fiber preparation. This is the first report of ethylene-oxide polyneuropathy in Brazil.

CONTENTS CONTEÚDO

Marcos R. G. de Freitas^I; Osvaldo J. M. Nascimento^II; Leila Chimelli^III

^IProfessor Adjunto, Chefe do Serviço de Neurologia - Disciplinas de Neurologia e Neuropatologia, Departamentos de Medicina Clínica e de Patologia, Faculdade de Medicina da Universidade Federal Fluminense

^IIProfessor Adjunto de Neurologia - Disciplinas de Neurologia e Neuropatologia, Departamentos de Medicina Clínica e de Patologia, Faculdade de Medicina da Universidade Federal Fluminense

^IIIProfessor Adjunto de Neuropatologia - Disciplinas de Neurologia e Neuropatologia, Departamentos de Medicina Clínica e de Patologia, Faculdade de Medicina da Universidade Federal Fluminense

RESUMO

Os autores referem-se a caso de um jovem que, trabalhando em fábrica de esterilização de artigos médicos e em contato diário com o óxido de etileno, desenvolveu leve polineuropatia sensitivo-motora. Os estudos eletrofisiológicos evidenciaram neuropatia por degeneração axonal. A biópsia do nervo sural mostrou discreta perda de fibras mielínicas e sinais de degeneração e regeneração axonal. Este é o primeiro caso desta afecção descrita em nosso meio.

SUMMARY

A man who worked as an operator in a factory of sterilization of heat-sen-sitive materials has been exposed to ethylene oxide for seven years. He developed a mild sensori-motor polyneuropathy. The electromyography and nerve conduction studies showed an axonal degenerative type of neuropathy. The sural nerve biopsy revealed mild loss of myelinated fibers, some fibers with axonial degeneration, some clusters of regeneration and few rows of myelin ovoids in the teased nerve fiber preparation. This is the first report of ethylene-oxide polyneuropathy in Brazil.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Dr. Marcos R. G. de Freitas - Departamento de Medicina Clínica, Hospital Universitário Antonio Pedro - Rua Marquês do Paraná 303

24030 Niterói RJ - Brasil.

1. Crystal HA, Schaumburg HH, Grober E, Fuld PA, Lipton RB. Cognitive impairment and sensory loss associated with chronic low-level ethylene oxide exposure. Neurology 1988, 38:567-569.
2. Estrin WJ, Cavalieri SA, Wald P, Beck CE, Jones JR, Cone JE. Evidence of neurologic dysfunction related to long-term ethylene oxide exposure. Arch Neurol 1987, 44:1283-1286.
3. Finelli PF, Morgan TF, Yaar I, Granger CV. Ehtylene oxide-induced polyneuropathy. Arch Neurol 1983, 40:419-421.
4. Gross JA, Haas ML, Swift TR. Ethylene oxide neurotoxicity : report of four cases and review of the literature. Neurology 1979, 29:978-983.
5. Kusuhara S, Kanazawa I, Nakanishi T, Egashira T. Ethylene oxide polyneuropathy. Neurology 1983, 33:377-380.
6. Ohnishi A, Inoue N, Yamamoto T, Murai Y, Hori H, Tanaka I, Koga M, Akiyama T. Ethylene neuropathy in rats: exposure to 250 ppm. J Neurol Sci 1986, 74:215-221.
7. Ohnishi A, Yamamoto T, Murai Y, Hayashid Y, Hori H, Tanaka I. Ethylene oxide causes central- peripheral neuropathy in rats. Arch Env Health 1988, 43:353-356.
8. Schaumburg HH, Spencer PS. Human toxic neuropathy due to industrial agents. In Dick PJ, Thomas PK, Lambert EH, Bunge R (eds) : Peripheral Neuropathy. Ed 2. Philadelphia: Sauders, 1984, p 2115-2132.
9. Schröder JM, Hoheneck M, Deist H. Ethylene oxide polyneuropathy: clinical follow-up study with morphometric and electron microscopic findings in a sural nerve biopsy. J Neurol 1985, 232:83-90.
10. Windebank AJ, Blexrud MD. Residual ethylene oxide in hollow fiber hemodyalysis units is neurotoxic in vitro. Ann Neurol 1989, 26:63-68.

Polineuropatia devida ao óxido de etileno registro de caso com estudo clínico, eletrofisiológico e histopatológico

Ethylene oxide polyneuropathy : a case report with clinical, electrophysiologic and histopatho-logical studies

Datas de Publicação

Publicação nesta coleção
22 Fev 2011
Data do Fascículo
Dez 1991

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Crystal HA, Schaumburg HH, Grober E, Fuld PA, Lipton RB. Cognitive impairment and sensory loss associated with chronic low-level ethylene oxide exposure. Neurology 1988, 38:567-569.

[2] 2. Estrin WJ, Cavalieri SA, Wald P, Beck CE, Jones JR, Cone JE. Evidence of neurologic dysfunction related to long-term ethylene oxide exposure. Arch Neurol 1987, 44:1283-1286.

[3] 3. Finelli PF, Morgan TF, Yaar I, Granger CV. Ehtylene oxide-induced polyneuropathy. Arch Neurol 1983, 40:419-421.

[4] 4. Gross JA, Haas ML, Swift TR. Ethylene oxide neurotoxicity : report of four cases and review of the literature. Neurology 1979, 29:978-983.

[5] 5. Kusuhara S, Kanazawa I, Nakanishi T, Egashira T. Ethylene oxide polyneuropathy. Neurology 1983, 33:377-380.

[6] 6. Ohnishi A, Inoue N, Yamamoto T, Murai Y, Hori H, Tanaka I, Koga M, Akiyama T. Ethylene neuropathy in rats: exposure to 250 ppm. J Neurol Sci 1986, 74:215-221.

[7] 7. Ohnishi A, Yamamoto T, Murai Y, Hayashid Y, Hori H, Tanaka I. Ethylene oxide causes central- peripheral neuropathy in rats. Arch Env Health 1988, 43:353-356.

[8] 8. Schaumburg HH, Spencer PS. Human toxic neuropathy due to industrial agents. In Dick PJ, Thomas PK, Lambert EH, Bunge R (eds) : Peripheral Neuropathy. Ed 2. Philadelphia: Sauders, 1984, p 2115-2132.

[9] 9. Schröder JM, Hoheneck M, Deist H. Ethylene oxide polyneuropathy: clinical follow-up study with morphometric and electron microscopic findings in a sural nerve biopsy. J Neurol 1985, 232:83-90.

[10] 10. Windebank AJ, Blexrud MD. Residual ethylene oxide in hollow fiber hemodyalysis units is neurotoxic in vitro. Ann Neurol 1989, 26:63-68.