The role of the endothelial dependent relaxing factor in the regulation of cerebral circulation

Salles, Antonio A. F. de

doi:10.1590/S0004-282X1988000100016

Abstracts

It has recently been demonstrated that vessel dilation induced by several physiological agents is dependent on an intact vascular endothelium. In order to explain this endothelium dependence, it has been hypothesized that a still unknown chemical substance, generically named Endothelium Dependent Relaxing Factor (EDRF) is necessary for physiological vasodilation. The role of this EDRF in the cerebrovascular physiology is not yet well understood. In this article the cerebrovascular physiological control is reviewed in relationship with possible EDRF actions. The importance of endothelial lesions in the cerebrovascular responses is discussed.

Recentemente foi descoberto que o endotélio vascular deve estar intacto para que vasos sanguíneos dilatem quando estimulados por agentes fisiológicos. Acredita-se que uma substância química ainda desconhecida, genericamente chamada Fator Relaxante Endotelial (FRE), produzida pelo endotélio, é indispensável para o relaxamento vascular. Neste trabalho é revista a fisiologia circulatória cerebral e possíveis ações do FRE. Discute-se também a importância de lesões endoteliais em relação ao controle circulatório cerebral.

Antonio A. F. de Salles

M.D., Ph.D. - Department of Physiology, Medical College of Virginia

SUMMARY

It has recently been demonstrated that vessel dilation induced by several physiological agents is dependent on an intact vascular endothelium. In order to explain this endothelium dependence, it has been hypothesized that a still unknown chemical substance, generically named Endothelium Dependent Relaxing Factor (EDRF) is necessary for physiological vasodilation. The role of this EDRF in the cerebrovascular physiology is not yet well understood. In this article the cerebrovascular physiological control is reviewed in relationship with possible EDRF actions. The importance of endothelial lesions in the cerebrovascular responses is discussed.

RESUMO

Recentemente foi descoberto que o endotélio vascular deve estar intacto para que vasos sanguíneos dilatem quando estimulados por agentes fisiológicos. Acredita-se que uma substância química ainda desconhecida, genericamente chamada Fator Relaxante Endotelial (FRE), produzida pelo endotélio, é indispensável para o relaxamento vascular. Neste trabalho é revista a fisiologia circulatória cerebral e possíveis ações do FRE. Discute-se também a importância de lesões endoteliais em relação ao controle circulatório cerebral.

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