Penicilinoterapia intravenosa em altas doses na neurossifilis: III. Avaliação de anticorpos antitreponêmicos da classe igm no liqüido cefalorraqueano e no soro

Nitrini, Ricardo; Veda, Mirthes; Vaz, Adelaide José; Spina-França, A.

doi:10.1590/S0004-282X1987000300004

Resumos

Anticorpos antitreponêmicos da classe IgM foram pesquisados no soro e no LCR de 9 casos de neurossífilis sintomática, antes e, em diversos momentos, depois do tratamento. Esses anticorpos foram investigados mediante reações de imunofluorescência (IgM-FTA-Abs), hemadsorção em fase sólida e imunoenzimática (ELISA). Os títulos das reações reduziram-se, mas houve persistência da reatividade no soro e no LCR no segundo ano após tratamento.

IgM antibodies against Treponema pallidum were investigated in the serum and in the CSF of 9 patients with symptomatic neurosyphilis, before the treatment and in several occasions after the treatment. Tests used were the FTA-Abs test, the IgM-solid phase hemadsorption test and an IgM-Elisa test. Titers of reactions decreased after treatment but they were still reactive in the blood and in the CSF during the second year after the treatment.

Penicilinoterapia intravenosa em altas doses na neurossifilis. III. Avaliação de anticorpos antitreponêmicos da classe igm no liqüido cefalorraqueano e no soro

High-dose intravenous penicillin G in the treatment of neurosyphilis. III. Evaluation of antitreponemic antibodies of the IgM class in cerebrospinal fluid and serum

Ricardo Nitrini^I; Mirthes Veda^II; Adelaide José Vaz^II; A. Spina-França^I

^IClínica Neurológica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

^IIInstituto Adolfo Lutz, Secretaria de Saúde do Estado de São Paulo

RESUMO

Anticorpos antitreponêmicos da classe IgM foram pesquisados no soro e no LCR de 9 casos de neurossífilis sintomática, antes e, em diversos momentos, depois do tratamento. Esses anticorpos foram investigados mediante reações de imunofluorescência (IgM-FTA-Abs), hemadsorção em fase sólida e imunoenzimática (ELISA). Os títulos das reações reduziram-se, mas houve persistência da reatividade no soro e no LCR no segundo ano após tratamento.

SUMMARY

IgM antibodies against Treponema pallidum were investigated in the serum and in the CSF of 9 patients with symptomatic neurosyphilis, before the treatment and in several occasions after the treatment. Tests used were the FTA-Abs test, the IgM-solid phase hemadsorption test and an IgM-Elisa test. Titers of reactions decreased after treatment but they were still reactive in the blood and in the CSF during the second year after the treatment.

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Clínica Neurológica, FMUSP - Caixa Postal 3461 - 01000 - São Paulo, SP - Brasil.

1. FRISCH-NIGGEMEYER, W. - Simple and rapid chromatographic separation of IgM using microcolumns and stained sera. J. virol. Method. 5:135, 1982.
2. GIBOWSKI, M. & MACHONKO, T. - Immunoglobulins in the cerebrospinal fluid of patients with late syphilis. Brit. J. vener. Dis. 57:20, 1981.
3. GIMÉNEZ-ROLDAN, S. & MARIN, M. - Tabetic lightning pains: high-dose intravenous penicillin versus carbamazepine therapy. Eur. Neurol. 20:424, 1981.
4. LEFÈVRE, J.C.; PRÈRE, M.F. ; ABRAL, M. & LARENG, M.B. - Apport du FTA-Abs quantitatif aux différents stades de la syphilis avant et après traitaient. Ann. Dermatol. Venereol. 110:425, 1983.
5. LUGER, A. - Diagnostic de la syphilis. Bull. Org. mond. Santé 60:17, 1982.
6. LUGER, A.; SCHMIDT, B. & SPENDLJNGWIMMER, I. - Quantitative evaluation of the FTA-ABS-IgM and VDRL test in treated and untreated syphilis. Brit. J. vener. Dis. 53:287, 1977.
7. LUGER, A.; SCHMIDT, B.L.; STEYRER, K. & SHONWALD, E. - Diagnosis of neurosyphilis by examination of the cerebrospinal fluid. Brit. J. vener. Dis. 57:232, 1981.
8. MANCINI, G.; CARBONARA, A.O. & HEREMAMS, I.F. - Immunochemical quantitations of antigens by single radial immunodiffusion. Immunochemistry 2:235, 1965.
9. MERLIN, S.; ANDRE, J.; ALACOQUE, B. & PARIS-HAMELIN, A. - Importance of specific IgM antibodies in 116 patients with various stages of syphilis. Genitourin. Med. 61:82, 1985.
10. MICHEL, D.; BLANC, A.; LAURENT, B.; FOYATIER, N. & PORTFAIX, M. - Étude biologique, psicométrique et tomodensimétrique de la neurosyphilis traitée. Rev. neurol. (Paris) 139:737, 1983.
11. MÜLLER, F. & LINDENSCHMIDT, E.G. - Demonstration of specific 19S(IgM) antibodies in untreated syphilis. Brit. J. vener. Dis. 58:12, 1982.
12. MÜLLER, F. & MOSKOSFHIDIS, M. - Evaluation of an enzyme immunoassay for IgM antibodies of Treponema pallidum in syphilis in man. Brit. J. vener. Dis. 60:288, 1984.
13. NITRINI, R.& SPINA-FRANCA, A. - Penicilinoteria intravenosa em altas doses na neurossífilis : estudo de 62 casos. II. Avaliação do liqüido cefalorraqueano. Arq. Neuro-Psiquiat. (São Paulo) 45:231, 1987.
14. O'NEILL, P. & NICOL, C.S. - IgM antitreponemal antibody in treated syphilis. Brit. J. vener. Dis. 48:460, 1972.
15. OXELIUS, V.A. ; RORSMAN, H. & LAURELL, A.B. - Immunoglobulins of cerebrospinal fluid in syphilis. Brit. J. vener. Dis. 45:121, 1969.
16. PEDERSEN, N.S.; PETERSEN, C.S. & AXELSEN, N.H. - Enzyme-linked immunoglobulin M antibody against the Reiter treponema flagellum in syphilis. J. clin. Microbiol. 16:608, 1982.
17. SCHMIDT, B. & BOLTZMANN, L. - The IgM-FTA-ABS test in the serum diagnosis of syphilis. World Health Organization, Geneva, 1979.
18. SCHMIDT, B.L. - Solid-phase hemadsorption: a method for rapid detection of Treponema pallidum specific IgM. Sex. Transm. Dis. 7:53, 1980.
19. SHANNON, R. & BOOTH, S.D. - The pattern of immunological responses at various stages of syphilis. Brit. J. vener. Dis. 53:281, 1977.
20. WILKINSON, A.E. & RODIN, P. - IgM-FTA test In syphilis in adults: its relation to clinical findings. Brit. J. vener. Dis. 52:219, 1976.

Datas de Publicação

Publicação nesta coleção
22 Jun 2011
Data do Fascículo
Set 1987

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. FRISCH-NIGGEMEYER, W. - Simple and rapid chromatographic separation of IgM using microcolumns and stained sera. J. virol. Method. 5:135, 1982.

[2] 2. GIBOWSKI, M. & MACHONKO, T. - Immunoglobulins in the cerebrospinal fluid of patients with late syphilis. Brit. J. vener. Dis. 57:20, 1981.

[3] 3. GIMÉNEZ-ROLDAN, S. & MARIN, M. - Tabetic lightning pains: high-dose intravenous penicillin versus carbamazepine therapy. Eur. Neurol. 20:424, 1981.

[4] 4. LEFÈVRE, J.C.; PRÈRE, M.F. ; ABRAL, M. & LARENG, M.B. - Apport du FTA-Abs quantitatif aux différents stades de la syphilis avant et après traitaient. Ann. Dermatol. Venereol. 110:425, 1983.

[5] 5. LUGER, A. - Diagnostic de la syphilis. Bull. Org. mond. Santé 60:17, 1982.

[6] 6. LUGER, A.; SCHMIDT, B. & SPENDLJNGWIMMER, I. - Quantitative evaluation of the FTA-ABS-IgM and VDRL test in treated and untreated syphilis. Brit. J. vener. Dis. 53:287, 1977.

[7] 7. LUGER, A.; SCHMIDT, B.L.; STEYRER, K. & SHONWALD, E. - Diagnosis of neurosyphilis by examination of the cerebrospinal fluid. Brit. J. vener. Dis. 57:232, 1981.

[8] 8. MANCINI, G.; CARBONARA, A.O. & HEREMAMS, I.F. - Immunochemical quantitations of antigens by single radial immunodiffusion. Immunochemistry 2:235, 1965.

[9] 9. MERLIN, S.; ANDRE, J.; ALACOQUE, B. & PARIS-HAMELIN, A. - Importance of specific IgM antibodies in 116 patients with various stages of syphilis. Genitourin. Med. 61:82, 1985.

[10] 10. MICHEL, D.; BLANC, A.; LAURENT, B.; FOYATIER, N. & PORTFAIX, M. - Étude biologique, psicométrique et tomodensimétrique de la neurosyphilis traitée. Rev. neurol. (Paris) 139:737, 1983.

[11] 11. MÜLLER, F. & LINDENSCHMIDT, E.G. - Demonstration of specific 19S(IgM) antibodies in untreated syphilis. Brit. J. vener. Dis. 58:12, 1982.

[12] 12. MÜLLER, F. & MOSKOSFHIDIS, M. - Evaluation of an enzyme immunoassay for IgM antibodies of Treponema pallidum in syphilis in man. Brit. J. vener. Dis. 60:288, 1984.

[13] 13. NITRINI, R.& SPINA-FRANCA, A. - Penicilinoteria intravenosa em altas doses na neurossífilis : estudo de 62 casos. II. Avaliação do liqüido cefalorraqueano. Arq. Neuro-Psiquiat. (São Paulo) 45:231, 1987.

[14] 14. O'NEILL, P. & NICOL, C.S. - IgM antitreponemal antibody in treated syphilis. Brit. J. vener. Dis. 48:460, 1972.

[15] 15. OXELIUS, V.A. ; RORSMAN, H. & LAURELL, A.B. - Immunoglobulins of cerebrospinal fluid in syphilis. Brit. J. vener. Dis. 45:121, 1969.

[16] 16. PEDERSEN, N.S.; PETERSEN, C.S. & AXELSEN, N.H. - Enzyme-linked immunoglobulin M antibody against the Reiter treponema flagellum in syphilis. J. clin. Microbiol. 16:608, 1982.

[17] 17. SCHMIDT, B. & BOLTZMANN, L. - The IgM-FTA-ABS test in the serum diagnosis of syphilis. World Health Organization, Geneva, 1979.

[18] 18. SCHMIDT, B.L. - Solid-phase hemadsorption: a method for rapid detection of Treponema pallidum specific IgM. Sex. Transm. Dis. 7:53, 1980.

[19] 19. SHANNON, R. & BOOTH, S.D. - The pattern of immunological responses at various stages of syphilis. Brit. J. vener. Dis. 53:281, 1977.

[20] 20. WILKINSON, A.E. & RODIN, P. - IgM-FTA test In syphilis in adults: its relation to clinical findings. Brit. J. vener. Dis. 52:219, 1976.

Brasil

Brasil

Penicilinoterapia intravenosa em altas doses na neurossifilis: III. Avaliação de anticorpos antitreponêmicos da classe igm no liqüido cefalorraqueano e no soro

High-dose intravenous penicillin G in the treatment of neurosyphilis: III. Evaluation of antitreponemic antibodies of the IgM class in cerebrospinal fluid and serum

Resumos

Datas de Publicação