Eosinofilorraquia em tumor maligno: apresentação de caso

Reis Filho, João Baptista dos; Zukerman, Eliova; Campos, Roberto

doi:10.1590/S0004-282X1985000300014

Resumos

A presença de granulócitos eosinófilos associados a tumores malignos que acometem o sistema nervoso tem sido raramente comunicada. O propósito deste registro é apresentar o caso de um paciente com 47 anos de idade com tumor cerebral maligno (astrocitoma grau III), cujo estudo citológico do LCR revelou quadro inflamatório com presença de elevada percentagem de granulócitos eosinófilos.

It is presented a case of a patient with a cerebral malignant astrocytoma in which the spinal fluid cytomorphology showed numerous eosinophilic granulocytes.

Eosinofilorraquia em tumor maligno: apresentação de caso

CSF eosinophils in malignant tumor: a case report

João Baptista dos Reis Filho^I; Eliova Zukerman^II; Roberto Campos^III

^IProfessor Adjunto Doutor da Escola Paulista de Medicina, Chefe do Setor de LCR e Pesquisador pelo CNPq

^IIProfessor Adjunto e Chefe do Departamento de Neurologia e Neurocirurgia da Escola Paulista de Medicina

^IIIResidente de Neurocirurgia da Escola Paulista de Medicina

RESUMO

A presença de granulócitos eosinófilos associados a tumores malignos que acometem o sistema nervoso tem sido raramente comunicada. O propósito deste registro é apresentar o caso de um paciente com 47 anos de idade com tumor cerebral maligno (astrocitoma grau III), cujo estudo citológico do LCR revelou quadro inflamatório com presença de elevada percentagem de granulócitos eosinófilos.

SUMMARY

It is presented a case of a patient with a cerebral malignant astrocytoma in which the spinal fluid cytomorphology showed numerous eosinophilic granulocytes.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Trabalho realizado no Departamento de Neurologia e Neurocirurgia da Escola Paulista de Medicina.

Disciplina de Neurologia, Escola Paulista de Medicina - Rua Botucatu, 740 - 04023, São Paulo, SP - Brasil.

1. CERVANTES, F.; MONTSERRAT, E. & ROZMAN, C. - Eosinophilic meningitis in Hodgkin's disease. Ann. int. Med. 91:930, 1979.
2. CIEMBRONIEWICZ, J. & KOLAR, O. - Eosinophilic response in glioblastoma tissue culture after addition of autologous lymphocytes. Science 157:1054, 1967.
3. COURTENAY, R.J. & McELWAIN, T.J. - Eosinophilic meningitis in Hodgkin's disease. Brit. J. clin. Pract. 23:382, 1969.
4. DEFENDINI, R.; HUNTER, S.B.; SCHLESINGER, E.B.; LEIFER, E. & ROWLAND, L.P. - Eosinophilic meningitis in a case of disseminated glioblastoma. Arch. Neurol. 38:52, 1981.
5. ESSELIER, A.F. & FORSTER, G. - Eosinophile encephalomeningitiden. Schweiz. med. Wsch. 87:822, 1957.
6. GILBERT, G.J. - CSF eosinophilia following myelography. J. amer. med. Assoc. 244:548, 1980.
7. ISAACSON, N.H. & RAPOPORT, P. - Eosinophilia in malignant tumors: its significance. Ann. int. Med. 25:893, 1946.
8. JAFFE, J.P. & LOPRINZI, C.L. - Basophilic-eosinophilic meningitis in an undifferentiated myeloproliferative disorder. J. amer. med. Assoc. 249:73, 1983.
9. KESSLER, L.A. & CHEEK, W.R. - Eosinophilia of the cerebrospinal fluid of non infectious origin. Neurology 9:371, 1959.
10. KING, D.K.; LOH, K.K.; AYALA, A.G. & GAMBLE, J.F. - Eosinophilic meningitis and lymphomatous meningitis. Ann. int. Med. 82:228, 1975.
11. KOLAR, O. & ZEMAN, W. - Spinal fluid cytomorphology. Arch. Neurol. 18:44, 1968.
12. KUBERSKI, T.; BART, R.D.; BRILEY, J.M. & ROSEN, L. - Recovery of Angiostrongylus cantonesis from cerebrospinal fluid of a child with eosinophilic meningitis. J. clin. Microbiol. 9:629, 1979.
13. LANGE, O. - Sobre as células eosinófilas no líquido cefalorraquiano. Rev. Neurol. Psiquiat. (São Paulo) 1:421, 1935.
14. REIS, J.B.; BEI, A. & REIS-FILHO, J.B. - Líquido Cefalorraquiano. Sarvier, São Paulo, 1980.
15. REIS, J.B.; PIMENTA, A.M. & PUPO, P.P. - Cerebrospinal fluid in the diagnosis of brain cysticercosis. Neurol. Psihiatr. Neurochir. (Roumania) 9:175, 1964.
16. VAILLANT, A.; PEYRIN, A.; CAVALLO, A. & BORDES, F.P. - Reflexions sur les rapports possibles entre les éosinophiles rachidiennes et l'ichtyotoxisme en Nouvelle Caledonie. Bull. Soc. Path. Exotique, 54:1075, 1961.
17. WASSERMAN, S.I.; GOETZL, E.J.; ELLMAN, L. & AUSTEN, K.S. - Tumor-associated eosinophilotactic factor. N. Engl. J. Med. 290:420, 1974.
18. WELLER, P.F. & GOETZL, E.J. - The regulatory and effector roles of eosinophils. Adv. Immunol. 27:339, 1979.

Datas de Publicação

Publicação nesta coleção
13 Ago 2012
Data do Fascículo
Set 1985

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. CERVANTES, F.; MONTSERRAT, E. & ROZMAN, C. - Eosinophilic meningitis in Hodgkin's disease. Ann. int. Med. 91:930, 1979.

[2] 2. CIEMBRONIEWICZ, J. & KOLAR, O. - Eosinophilic response in glioblastoma tissue culture after addition of autologous lymphocytes. Science 157:1054, 1967.

[3] 3. COURTENAY, R.J. & McELWAIN, T.J. - Eosinophilic meningitis in Hodgkin's disease. Brit. J. clin. Pract. 23:382, 1969.

[4] 4. DEFENDINI, R.; HUNTER, S.B.; SCHLESINGER, E.B.; LEIFER, E. & ROWLAND, L.P. - Eosinophilic meningitis in a case of disseminated glioblastoma. Arch. Neurol. 38:52, 1981.

[5] 5. ESSELIER, A.F. & FORSTER, G. - Eosinophile encephalomeningitiden. Schweiz. med. Wsch. 87:822, 1957.

[6] 6. GILBERT, G.J. - CSF eosinophilia following myelography. J. amer. med. Assoc. 244:548, 1980.

[7] 7. ISAACSON, N.H. & RAPOPORT, P. - Eosinophilia in malignant tumors: its significance. Ann. int. Med. 25:893, 1946.

[8] 8. JAFFE, J.P. & LOPRINZI, C.L. - Basophilic-eosinophilic meningitis in an undifferentiated myeloproliferative disorder. J. amer. med. Assoc. 249:73, 1983.

[9] 9. KESSLER, L.A. & CHEEK, W.R. - Eosinophilia of the cerebrospinal fluid of non infectious origin. Neurology 9:371, 1959.

[10] 10. KING, D.K.; LOH, K.K.; AYALA, A.G. & GAMBLE, J.F. - Eosinophilic meningitis and lymphomatous meningitis. Ann. int. Med. 82:228, 1975.

[11] 11. KOLAR, O. & ZEMAN, W. - Spinal fluid cytomorphology. Arch. Neurol. 18:44, 1968.

[12] 12. KUBERSKI, T.; BART, R.D.; BRILEY, J.M. & ROSEN, L. - Recovery of Angiostrongylus cantonesis from cerebrospinal fluid of a child with eosinophilic meningitis. J. clin. Microbiol. 9:629, 1979.

[13] 13. LANGE, O. - Sobre as células eosinófilas no líquido cefalorraquiano. Rev. Neurol. Psiquiat. (São Paulo) 1:421, 1935.

[14] 14. REIS, J.B.; BEI, A. & REIS-FILHO, J.B. - Líquido Cefalorraquiano. Sarvier, São Paulo, 1980.

[15] 15. REIS, J.B.; PIMENTA, A.M. & PUPO, P.P. - Cerebrospinal fluid in the diagnosis of brain cysticercosis. Neurol. Psihiatr. Neurochir. (Roumania) 9:175, 1964.

[16] 16. VAILLANT, A.; PEYRIN, A.; CAVALLO, A. & BORDES, F.P. - Reflexions sur les rapports possibles entre les éosinophiles rachidiennes et l'ichtyotoxisme en Nouvelle Caledonie. Bull. Soc. Path. Exotique, 54:1075, 1961.

[17] 17. WASSERMAN, S.I.; GOETZL, E.J.; ELLMAN, L. & AUSTEN, K.S. - Tumor-associated eosinophilotactic factor. N. Engl. J. Med. 290:420, 1974.

[18] 18. WELLER, P.F. & GOETZL, E.J. - The regulatory and effector roles of eosinophils. Adv. Immunol. 27:339, 1979.