Eficácia clínica e microbiológica da norfloxacina tópica 0,3% no tratamento de infecções oculares externas ^*

Clinical and microbiological effectiveness of topical norfloxacin 0,3% in the treatment of external ocular infections

RESUMO

Foi avaliada a eficácia clínica e microbiológica da norfloxacina a 0,3 % contra 24 cepas de Staphylococcus aureus e 15 cepas de anaeróbios isolados de 27 pacientes portadores de infecção ocular superficial externa.

Comparou-se a eficácia microbiológica da norfloxacina com as da gentamicina, tobramicina, cloranfenicol, ciprofloxacina, ácido nalidíxico, ofloxacina, cefalotina e associação de antibióticos (oftrim), vancomicina e amicacina no pré e pós-tratamento com norfloxacina tópica 0,3%. Obteve-se eficácia clínica com o tratamento tópico em 83,3% dos pacientes portadores de infecção ocular superficial externa por S. aureus.

Nenhum microrganismo anaeróbio foi sensível à norfloxacina.

Palavras-chave:
quinolona; norfloxacina; Staphylococcus aureus; anaeróbios; infecção ocular

SUMMARY

Clinical and microbiological effectiveness of topical norfloxacin 0,3% were evaluated against 23 strains of Staphylococcus aureus and 15 strains of anaerobic bacteria from 27 outpatients with infectious external superficial ocular diseases.

The microbiological effectiveness of norfloxacin was compared with gentamicin, tobramicin, cloranfenicol, cyprofloxacin, nalidixic acid, ofloxacin, cefalotin, antimicrobial association (oftrim), vancomycin and amycacin, before and after the course of topical norfloxacin 0,3%. The clinical effectiveness was achieved in 83,3% of the outpatients with infectious external superficial ocular disease caused by S. aureus.

None of the anaerobial microrganisms was sensitive to norfloxacin.

Key words:
quinolone; norfloxacin; Staphylococcus aureus; anaerobial organisms; ocular infections; antibiogram

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AGRADECIMENTOS

À Merck Sharp & Dohme-Chibret por ceder os colírios de norfloxacina 0,3% (“Chibroxin”).

À Professora Adjunta Maria Regina Fernandes de Toledo, da Disciplina de Microbiologia da Escola Paulista de Medicina, pelas valiosas sugestões na elaboração deste trabalho.

À Dra. Lícia de Queiroz Campos Deveza e Silva, Chefe do Setor de Bactérias Anaeróbias do Hospital São Paulo, por tornar possível a realização da investigação com os anaeróbios.

• *
  Trabalho realizado no Laboratório da Patologia Externa do Departamento de Oftalmologia da Escola Paulista de Medicina e Laboratório Central - Setor de Bactérias Anaeróbias do Hospital São Paulo.

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Datas de Publicação

• Publicação nesta coleção
  Sep-Oct 1991