Jaw osteosarcoma and pregnancy: a rare coexistence

Santos, Thaís Aguiar; Américo, Márcia Gimenes; Priante, Antonio Vitor Martins; Oliveira, Maria Fernanda de; Anbinder, Ana Lia

doi:10.4322/acr.2021.359

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Sumário

Clinical Case Report and Review • Autops. Case Rep. 12 • 2022 • https://doi.org/10.4322/acr.2021.359 copy

Jaw osteosarcoma and pregnancy: a rare coexistence

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Osteosarcoma of the jaw represents less than 1% of all head and neck malignancies. This malignancy in pregnant women occurs in one per 1000 deliveries. We report a case of a 29-year-old woman, in the 33rd week of gestation, who presented with an expansive tumor destroying the maxillary alveolar bone, histologically composed of pleomorphic, round, spindle, or epithelioid cells and osteoid/chondroid matrix. Upon final diagnosis of osteosarcoma, the lesion was excised. To the best of our knowledge, only 10 cases of jaw osteosarcoma in pregnant women have been reported to date in the English language literature. The use of ancillary examinations, malignancy diagnosis, and cancer treatment can be challenging during pregnancy. Knowledge about jaw osteosarcoma in pregnancy can increase healthcare providers’ awareness, avoid delays and misdiagnosis and potentially improve maternal and neonatal outcomes.

Keywords
Osteosarcoma; Pregnancy; Bone Neoplasms

Ref	Age	Site	Trimester of pregnancy when osteosarcoma was diagnosed		Treatment	Delivery and condition of the babies
10	NA	Mandible	3rd	NA	Surgery	normal
10	NA	Mandible	2nd	NA	Surgery, radiation therapy	Full term, normal
11	38	Mandible	3rd	Chondroblastic and osteoblastic	Surgery	Full term, cesarian birth, normal
12	28	Mandible	1st	Small cell	Surgery and Chemotherapy	Therapeutic abortion
13	38	Mandible	NA	Chondroblastic	NA	NA
14	22	Maxilla	3rd	Epithelioid	NA	NA
15	25	Mandible	2nd	Pleomorphic	Surgery, Radiation and Chemotherapy	Therapeutic abortion
16	31	Maxilla	3rd	Chondroblastic	Neoadjuvant chemotherapy and Surgery	Pregnancy interrupted in the 33^rd week
17	NA	Mandible	3rd	Chondroblastic	Surgery, radiation therapy	Induced delivery at 35 weeks
18	20	Mandible	1st	Chondroblastic	Surgery, NA	Pregnancy interrupted, NA
Index case	29	Maxilla	3rd	Chondroblastic	Surgery, Radiation and Chemotherapy	Induced delivery, full term, normal

Hospital Universitário da Universidade de São Paulo Hospital Universitário da Universidade de São Paulo, Av. Prof. Lineu Prestes, 2565 - Cidade Universitária, 05508-000 - São Paulo - SP - Brasil, (16) 3307-2068, (16) 3307-2068 - São Paulo - SP - Brazil
E-mail: autopsy.hu@gmail.com

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[1] Authors’ contributions: Thaís Aguiar Santos revised the literature, drafted the paper, revised it critically and approved the final version to be published. Márcia Gimenes Américo, Antonio Vitor Martins Priante and Maria Fernanda de Oliveira performed the clinical examination, initial diagnosis, surgery, patient follow up, revised the paper critically and approved the final version to be published. Ana Lia Anbinder performed the histological diagnosis of the first biopsy, revised all histopathological slides, drafted the paper, revised it critically and approved the final version to be published.