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Clinical Case Report • Autops. Case Rep. 11 • 2021 • https://doi.org/10.4322/acr.2021.340   copy

Mantle cell lymphoma presenting with lethal atraumatic splenic rupture

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Mantle cell lymphoma is characterized by t(11;14) with CCND1-IGH fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic rupture. We discuss on the implications of variant CCND1 signal patterns as well as the epidemiology and pathophysiology of atraumatic splenic rupture.

Keywords
Lymphoma, Mantle-Cell; Splenic Rupture; Cyclin D; Lymphoma, Malignant

Hospital Universitário da Universidade de São Paulo Hospital Universitário da Universidade de São Paulo, Av. Prof. Lineu Prestes, 2565 - Cidade Universitária, 05508-000 - São Paulo - SP - Brasil, (16) 3307-2068, (16) 3307-2068 - São Paulo - SP - Brazil
E-mail: autopsy.hu@gmail.com
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