The relationship between the development of hepatomegaly, splenomegaly, body weight and mortality rate and the degree of susceptibility of Biomphalaria glabrata and B. tenagophila at which infective cercariae developed was studied. The study utilized Swiss mice, SPF, as definitive hosts and populations of snails genetically selected for character susceptibility as intermediate hosts. Low body weight and smaller viscera were observed in infected mice with cercariae originating from snails that showed a high degree of susceptibility. The higher susceptibility of molluscs infected with S. mansoni corresponded to a lower survival of the infected mice. These results lead to the conclusion that the higher degree of adaptation of the parasite to its intermediate hosts, evidenced by the high indexes of susceptibility, leads to different behaviour on the part of this parasite in its definitive host.
Biomphalaria; Schistosoma mansoni; Hepatomegaly; Splenomegaly
