Laboratory chemical waste: hazard classification by GHS and transport risk

Giovanni, Cássio; Marques, Fabio Luiz Navarro; Günther, Wanda Maria Risso

doi:10.11606/s1518-8787.2021055003259

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Original Article • Rev. Saúde Pública 55 • 2021 • https://doi.org/10.11606/s1518-8787.2021055003259 copy

Laboratory chemical waste: hazard classification by GHS and transport risk

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

OBJECTIVES:

To identify and evaluate, based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) and the legislation of the Agência Nacional de Transportes Terrestres (ANTT – National Agency for Terrestrial Transport), the hazards arising from chemical waste generated in research laboratories in the health area.

METHODS:

Chemical residues generated in two medical research laboratories of the Faculdade de Medicina da Universidade de São Paulo were inventoried, from November 2017 to April 2019, and classified according to the GHS (hazard statements) and the ANTT transport legislation (risk classes), to determine the dangers coming from the respective substances and mixtures.

RESULTS:

In total, we identified 40 substances or mixtures with classification by the GHS indicating 36 hazard statements, 27 of which related to human health. According to the legislation established by ANTT, we found 16 cases of hazard associated with flammability, 15 cases related to toxicity and 12 cases related to corrosivity.

CONCLUSIONS:

Chemical residues generated in the laboratories studied are diversified in terms of their hazard characteristics, implying the possibility of exposure to severe risks to workers, students and the environment. The correct identification of these residues is a primary factor for reducing exposure to risks.

DESCRIPTORS:
Chemical Waste; Hazardous Waste; Product Labeling; Substances, Products and Materials Transportation

Chemical residue composition	Hazard statements (GHS codes)	Class or subclass of risk and subsidiary risk (ANTT)
Acetone	H225, H319, H336	3
Hydrochloric acid, solution	H290, H314, H331	8
Picric acid	H201, H301, H311, H331	4.1
Beta-mercaptoethanol	H301, H310, H311, H315, H318, H331, H400, H411	6.1
Phenol	H301, H311, H314, H331, H341, H373, H411	6.1
Formaldehyde	H301, H311, H314, H317, H330, H331, H334, H335, H351	3, 8
Empty bottle contaminated by silane	H315	9
Empty jars	It is not possible to determine the hazards, as the contaminating chemical residues had not been specified	9
Methyl methacrylate	H225, H315, H317, H335	3
Methanol	H225, H301, H311, H331, H360, H370	3, 6.1
Mixture of xylenes	H226, H304, H312, H315, H332	3
Mixture: acetone with silane	H225, H319, H336	3
Aqueous solution: hydrogen peroxide and methanol	H225, H301, H311, H331, H360, H370	3, 6.1
Toluene	H225, H304, H315, H336, H361, H373	3

Chemical residue composition	Hazard statements (GHS codes)	Class or subclass of risk and subsidiary risk (ANTT)
Acetic acid	H314, H226	8
Azathioprine	H302, H315, H319, H335, H340, H350, H360, H361, H372	Substance or mixture not classified as hazardous for transport purposes
Dipyrone (Metamizole)	H302, H317, H334, H341, H351, H412	Substance or mixture not classified as hazardous for transport purposes
Class I filter for organic vapors (such as formaldehyde and methylamine), chlorine, chlorine dioxide, hydrofluoric acid, sulfur dioxide, hydrogen sulfide, ammonia and nitrogen dioxide	H331, H411	9
Agarose gel and tips with Sybr Safe® or Gel Red	It has no harmonized classification or risks notified by manufacturers, importers or users of this substance	Substance or mixture not classified as hazardous for transport purposes
Agarose gel and tips contaminated by Sybr Safe ® dye, red Gel or trizol (guanidine phenol isothiocyanate)	H301, H302, H311, H312, H314, H331, H332, H373, H411	6.1, 8
Sodium hydroxide	H290, H314	8
Leflunomide	H301, H315, H319, H335, H360, H361, H372	6.1
Lugol (aqueous solution of iodine and potassium iodide)	H312, H315, H317, H319, H332, H372, H400	8
Sodium mycophenolate	H302, H341, H360, H372, H410	9
Mixture: acetone, silane, formaldehyde, picric acid and acetic acid	H205, H225, H226, H301, H311, H314, H317, H319, H318, H330, H331, H334, H335, H336, H351	3, 8
Mixture: chloroform and phenol	H301, H302, H311, H314, H315, H319, H331, H341, H351, H361, H373, H411	6.1
Mixture: ethanol and formaldehyde	H225, H301, H311, H314, H317, H319, H330, H331, H334, H335, H351, H371	3, 8
Mixture: glutaraldehyde and silane	H226, H301, H314, H317, H330, H334, H335, H400, H411	8, 3
Mixture: methanol, bromophenol blue, glycine and tris (hydroxymethyl) aminomethane (TRIS)	H225, H301, H311, H312, H315, H319, H331, H332, H335, H360, H370	3, 6.1
Mixture: xylenes, ethanol, hydrogen peroxide, hematoxylin, 3,3' - diaminobenzidine and 3-amino-9-ethylcarbazole	H225, H226, H302, H304, H312, H315, H319, H332, H335, H336, 341, H350, H371	3, 6.1, 8
Mixture: xylenes, formaldehyde, ethanol, hydrogen peroxide, Fast Red, 3,3'-diaminobenzidine, 3-amino-9-ethylcarbazole, acetone, silane, picric acid and acetic acid	H225, H226, H301, H302, H304, H311, H312, H314, H315, H317, H319, H330, H331, H332, H334, H335, H341, H350, H351	3, 6.1, 8
Mixture: xylenes, formaldehyde, methanol, ethanol, hydrogen peroxide, acetic acid, Fast Red, 3,3'-diaminobenzidine, 3-amino-9-ethylcarbazole and acetone	H226, H301, H302, H304, H311, H312, H314, H315, H317, H319, H330, H331, H332, H334, H335, H341, H350, H351, H360, H370	3, 6.1, 8
N, n'-methylenebisacrylamide	H301, H302, H317, H318, H332, H340, H351, H360, H361, H372	6.1
Paracetamol	H302, H315, H317, H319, H332, H335, H341, H370, H371, H372, H373, H412	Substance or mixture not classified as hazardous for transport purposes
Prednisone	H312, H315, H319, H332, H360, H361, H373	Substance or mixture not classified as hazardous for transport purposes
Dowex ion exchange resin	H315, H318, H319, H335	Substance or mixture not classified as hazardous for transport purposes
5-bromo-2’-deoxyuridine (BrdU)solution	H315, H319, H335, H340, H341, H361	Substance or mixture not classified as hazardous for transport purposes
Fuchsin solution with phenol	H301, H302, H311, H314, H331, H341, H351, H373, H411	6.1
Buffer with beta-mercaptoethanol	H301, H310, H311, H315, H318, H331, H400, H411	6.1
Buffer with methanol	H225, H301, H311, H331, H360, H370	3, 6.1

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E-mail: revsp@usp.br

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[1] Correspondence: Cássio Giovanni, Rua Sena Madureira, 1.500, 3° andar, Vila Clementino 04021-001 São Paulo, SP, Brasil E-mail: cgiovanni@unifesp.br