Histopathology and immunohistochemistry of skin and oral mucosa in disseminated histoplasmosis associated with acquired immunodeficiency syndrome (AIDS)

Biopsy specimens of the skin and oral mucosa from twenty-five patients bearing the disseminated form of histoplasmosis (H. capsulatum) associated with AIDS (aquired immunodeficiency syndrome) were studied by histologic and immunohistochemistry techniques. Histologically, the skin lesions showed four different patterns: diffuse macrophage, granulomatous, vasculitic with leucocytoclastic and scarce inflammatory reaction. The cell markers for macrophages, lymphocytes B and T and H. capsulatum revealed CD68, UCHL-1 and L26 associated with variable amounts of fungi.

Skin; Oral mucosa; Histoplasmosis; Disseminated histoplasmosis; AIDS