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Short Communications • Rev. Soc. Bras. Med. Trop. 50 (04) • Jul-Aug 2017 • https://doi.org/10.1590/0037-8682-0171-2016   copy

Sporothrix brasiliensis produces the highest levels of oxidative stress in a murine model among the species of the Sporothrix schenckii complex

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION:

We compared indicators of oxidative stress in the tissue of mice infected with strains from Sporothrix schenckii complex.

METHODS:

Mice were inoculated with Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa, Sporothrix mexicana or Sporothrix albicans. The activity of catalase and glutathione were accessed in the liver and spleen.

RESULTS:

Animals infected with S. brasiliensis exhibited splenomegaly and significant decrease in catalase activity, and protein and non-protein thiol content compared to animals infected with the other species.

CONCLUSIONS:

Sporothrix brasiliensis exhibits higher pathogenicity compared to other species of the Sporothrix schenckii complex by increasing oxidative stress in animal tissue.

Key words:
Sporotrichosis; Antioxidant enzymes; Oxidative stress

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