Polymorphism in the interleukin-10 gene is associated with overactive bladder phenotype associated with HTLV-1 infection

Braz, Marcos; Oliveira, Joyce Moura; Rêgo, Jamile Leão; Carvalho, Edgar Marcelino de; Santos, Silvane Maria Braga; Castellucci, Léa Cristina

doi:10.1590/0037-8682-0481-2018

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Revista da Sociedade Brasileira de Medicina Tropical

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Sumário

Short Communication • Rev. Soc. Bras. Med. Trop. 52 • May 2019 • https://doi.org/10.1590/0037-8682-0481-2018 copy

Polymorphism in the interleukin-10 gene is associated with overactive bladder phenotype associated with HTLV-1 infection

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION

Human T-cell lymphotropic virus type 1 (HTLV-1)-associated inflammatory diseases are not well understood; however, their clinical manifestations may be influenced by the host genetic background.

METHODS

We genotyped 298 individuals with HTLV-1 and 380 controls for interleukin-10 (IL10) gene variants-rs3024496, rs1800871, rs1800896-and used logistic regression analysis to determine their association with clinical phenotypes.

RESULTS

No association with HTLV-1 infection was observed. However, allele A of rs1800896 (1082bp upstream) was associated with protection against neurological impairment, specifically overactive bladder (OR=0.447, 95% CI 0.28-0.70, p=0.001).

CONCLUSIONS

Our data suggests that IL10 regulation ameliorates neurological damage in HTLV-1 infections.

Keywords:
HTLV-1; SNP rs1800896 (-1082bp A/G); Overactive bladder

Characteristics	Carriers		Overactive bladder		HAM/TSP		Total
	N	%	N	%	N	%	N	%
	164	55.03	63	21.14	71	23.83	298	100
Male*	63	38.4	15	23.8	22	30.9	100	33.5
Age>50 years*	47	74.6	74	46.6	10	45.4	64	64
Age≤50 years*	16	25.4	8	53.3	12	54.5	36	36
Female*	101	61.5	48	76.2	49	69	198	66.4
Age>50 years*	57	56.4	30	62.5	32	65.3	119	60.1
Age≤50 years*	44	43.5	18	37.5	17	34.7	79	39.9
Average age (min-max)	51 (23-76)		54	(29-70)	53	(27-78)	53	(23-78)

IL10 rs1800896 (-1082 bp)	CASES		CONTROLS		TOTAL
	N	%	N	%	N	%
A	379	67,2	398	63	777	65,0
G	185	32,8	234	37	419	35,0
AA	130	46,1	129	40,8	259	43,3
AG	119	42,2	140	44,3	259	43,3
GG	33	11,7	47	14,9	80	13,4
IL10 rs1800871 (-819 bp)
A	196	37,3	231	37,9	427	37,6
G	330	62,7	379	62,1	709	62,4
AA	42	16	43	14,1	85	15,0
AG	112	42,6	145	47,5	257	45,2
GG	109	41,4	117	38,4	226	39,8
IL10 rs3024496 (+4976 bp)
A	321	62,2	372	60,8	693	61,4
G	195	37,8	240	39,2	435	38,6
AA	109	42,2	111	36,3	220	39,0
AG	w103	39,9	150	49,0	253	44,9
GG	46	17,8	45	14,7	91	16,1

Cases Vs. Controls
IL-10_rs1800896	OR	CI (95%)	P
A	1,194	0,94-1,50	0,136
G	0,837	0,66-1,05	0,136
A/G X G/G	1,210	0,72-2,01	0,461
A/A X G/G	1,435	0,86-2,38	0,163

IL-10_rs1800871	OR	CI (95%)	P
A	0,975	0,76-1,23	0,836
G	1,025	0,80-1,29	0,836
A/G X G/G	0,829	0,57-1,18	0,306
A/A X G/G	1,048	0,63-1,72	0,853

IL-10_rs3024496	OR	CI (95%)	P
A	1,058	0,83-1,33	0,633
G	0,944	0,74-1,19	0,633
A/G X G/G	0,671	0,41-1,08	0,105
A/A X G/G	0,960	0,58-1,56	0,872
Stratification of individuals by clinical form
(A)
IL-10_rs1800896	OR	CI (95%)	P	P corrected
A	0,447	0,28-0,70	0,001	0,009
G	2,235	1,40-3,54	0,001	0,009
A/G X G/G	0,300	0,12-0,74	0,0001	0,0009
A/A X G/G	0,175	0,06-0,45	0,0001	0,0009
(B)
IL-10_rs1800896	OR	CI (95%)	P	*P corrected*
A	0,987	0,63-1,53	0,956	0,36
G	1,012	0,65-1,57	0,956	0,36
A/G X G/G	0,505	0,18-1,40	0,376	0,16
A/A X G/G	0,669	0,24-1,80	0,376	0,16

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[1] Corresponding author: Léa Cristina Castellucci. e-mail:leacastel@hotmail.com