Acessibilidade / Reportar erro
Short Communication • Rev. Soc. Bras. Med. Trop. 52 • May 2019 • https://doi.org/10.1590/0037-8682-0376-2018   copy

Epidemiological and TNFα polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in North Brazil

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION:

The present study evaluated the epidemiology of cryptococcal meningitis and TNFα gene polymorphisms in patients at a reference hospital in northern Brazil.

METHODS:

Samples from 25 patients infected with Cryptococcus spp. were collected to confirm the infection and to analyze the TNFα gene polymorphisms.

RESULTS:

Cryptococcus neoformans was detected as the predominant etiological agent (100%) in HIV-positive patients. No genetic polymorphic changes were found.

CONCLUSIONS:

No correlation was observed between the analyzed TNFα polymorphisms and cryptococcal meningitis.

Keywords:
Cryptococcal meningitis; Genetic polymorphisms; Cerebrospinal fluid; TNFα

Sociedade Brasileira de Medicina Tropical - SBMT Caixa Postal 118, 38001-970 Uberaba MG Brazil, Tel.: +55 34 3318-5255 / +55 34 3318-5636/ +55 34 3318-5287, http://rsbmt.org.br/ - Uberaba - MG - Brazil
E-mail: rsbmt@uftm.edu.br
Acompanhe os números deste periódico no seu leitor de RSS