Abstract
INTRODUCTION:
Essential oils can serve as novel sources of antibiotics for multidrug-resistant bacteria.
METHODS:
The multidrug-resistance profile of a Klebsiella aerogenes strain was assessed by PCR and sequencing. The antibacterial activity of Cinnamomum cassia essential oil (CCeo) against K. aerogenes was assessed by broth microdilution and time-kill methods.
RESULTS:
K. aerogenes showed high antibiotic resistance. The genes bla KPC-2, ampC, bla CTX-M-15, bla OXA-1, and bla TEM were present. CCeo exhibited an inhibitory effect with a minimum inhibitory concentration of 17.57 μg/mL.
CONCLUSIONS:
The antibacterial activity of CCeo makes it a potential candidate for treating carbapenem- and polymyxin-resistant K. aerogenes strains.
Keywords:
Drug resistance; Cinnamon oil; Carbapenem-resistant Enterobacterales; Gram-negative bacteria; Klebsiella aerogenes; Polymyxin resistance