Survival analysis of patients with sepsis in Brazil

Patients with sepsis, severe sepsis, and septic shock were followed up and clinical and laboratory data were collected. The sepsis-related organ failure assessment (SOFA) score was calculated. RESULTS: The overall 30-day survival rates of patients with sepsis, severe sepsis, and septic shock were 86.3%, 72.5%, and 20%, respectively. Mortality was related to old age, septic shock, coagulopathy, lactate level, and high SOFA score among other factors.

CONCLUSIONS:

Identification of prognostic variables may reduce sepsis-related mortality.

Keywords:
Sepsis; Severe sepsis; Septic shock; Mortality; Survival

	N	Incidence (%)	15-day survival	Confidence	30-day survival	Confidence	P-value
			rate (%)	interval (%)	rate (%)	interval (%)
Sepsis (without any organ dysfunction)	56	54.90	97.4	94.80-100.00	0.836	76.70-90.50	<0.001
Severe sepsis	36	35.29	82.2	75.50-88.90	0.725	63.80-81.20
Septic shock	10	9.80	30.0	15.50-44.5	0.2	7.40-32.60
Male	42	41.18	85.20	79.60-90.80	68.30	59.10-77.50	<0.708
Female	60	58.82	84.00	78.70-89.30	74.50	67.50-81.50
Age ≤49 years	35	34.31	100.00	100.00	87.00	77.90-96.10	<0.014
Age >49 years	67	65.69	76.80	71.30-82.30	64.70	57.80-71.60
SOFA score ≤2	55	53.92	97.14	94.32-99.95	86.17	79.66-92.68	<0.001
SOFA score >2	47	46.08	68.15	61.04-75.26	57.73	49.48-65.97
Hyperthermia >38.3ºC	15	14.71	92.90	86.00-99.80	82.50	71.00-94.00	<0.591
Hypothermia <35ºC	9	8.82	77.80	63.90-91.70	43.20	22.40-64. 00	<0.035
Tachycardia >90 bpm	79	77.45	83.60	79.00-88.20	69.70	63.20-76.20	<0.632
Tachypnea >20 rpim	68	66.67	83.80	79.10-88.50	68.60	61.60-75.60	<0.352
Leukocytosis >12,000	75	73.53	84.00	79.50-88.50	69.40	62.80-76.00	<0.802
Leukopenia <4,000	4	3.92	83.80	79.80-87.80	70.80	65.8-75.88	<0.382
Recent or increased need of SpO₂ >90%	16	15.69	43.80	30.20-57.40	43.80	30.20-57.40	<0.001
PaO₂/FiO₂ <300	13	12.75	61.50	48.00-75.00	51.30	36.70-65.90	<0.038
Coagulopathy (INR >1.5 or PTT >60 seconds)	4	3.92	25.00	3.35-46.65	25.00	3.35-46.65	<0.001
Lactate >2 mmol/dL	14	13.73	61.90	48.26-75.49	42.42	27.59-57,25	<0.001
Platelet count <100,000	8	7.84	75.00	59.69-90.30	60.00	41.83-78.16	<0.273
SBP <90 or MAP <65 mmHg	18	17.65	57.43	45.12-69.73	57.43	45.12-69.73	<0.034
Drop in BP >40 mmHg	9	8.82	66.66	51.49-82.37	66.66	51.49-82.37	<0.568
Creatinine >2 mg/dL or diuresis <0.5 mL/kg/h	19	18.63	59.23	40.02-71.44	50.77	37.70-63.84	<0.002
Bilirubin >2 mg/dL	7	6.86	68.57	49.94-87.19	0.00	0.00	<0.035
Referred with sepsis from another institution	24	23.53	78.70	70.23-87.18	63.94	51.99-75.90	<0.278

Sociedade Brasileira de Medicina Tropical - SBMT Caixa Postal 118, 38001-970 Uberaba MG Brazil, Tel.: +55 34 3318-5255 / +55 34 3318-5636/ +55 34 3318-5287, http://rsbmt.org.br/ - Uberaba - MG - Brazil
E-mail: rsbmt@uftm.edu.br

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[1] Corresponding author: Eliane Pereira da Silva. e-mail: elilips@hotmail.com