Decreased uric acid levels in the acute phase of <i>Plasmodium vivax</i> malaria

Gomes, Luciano Teixeira; Bellei, Ananda Karla; Andrade, Denise Inácio de; Gotardo, Priscila Zanini; Nery, Andreia Ferreira; Fontes, Cor Jesus Fernandes

doi:10.1590/0037-8682-0412-2017

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Short Communication • Rev. Soc. Bras. Med. Trop. 52 • 2019 • https://doi.org/10.1590/0037-8682-0412-2017 copy

Decreased uric acid levels in the acute phase of Plasmodium vivax malaria

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION

Uric acid is one of the compounds associated with the inflammatory process in malaria. It acts as an indicator of cellular damage by activating the immune response and inflammatory process.

METHODS:

We measured serum concentrations of uric acid in 60 symptomatic patients before and after treatment for malarial infections caused by Plasmodium vivax.

RESULTS:

Lower serum concentrations of uric acid were found during the acute phase of P. vivax malaria compared to those in its convalescent phase (p < 0.0001).

CONCLUSIONS:

Patients in the acute phase of malaria had lower uric acid levels than those in its convalescent phase.

Keywords:
Malaria; Uric acid; Acute phase; Convalescent phase

Characteristics	Acute phase (n=60)	Convalescent phase (n=60)	P value*
Age (years)	45.0 (29.5-55.0)		-
Median (1^st-3^rd quartile)
Time clinical reevaluation (days)	9.4 (5.7)		-
Mean (standard deviation)
Parasitemia (parasites/µL)	4,000 (1,300-11,500)		-
Median (1^st-3^rd quartile)
Hemoglobin^a (g/dL)	13.2 (11.9-14.3)	13.0 (11.8-14.3)	0.068
Hematocrit^a (%)	38.5 (35.7-42.7)	38.6 (34.8-41.9)	0.447
Total leukocytes^b (leukocytes /µL)	5,150 (4,325-6,305)	6,700 (5732-7,700)	<0.0001*
Total bilirrubin^b (mg/dL)	1.0 (0.6-1.7)	0.5 (0.3-0.6)	<0.0001*
Urea^b (mg/dL)	29.0 (24.3-37.8)	26.0 (21.0-33.0)	0.007
Creatinine^b (mg/dL)	0.9 (0.8-1.1)	0.9 (0.8-1.1)	1.000
Aspartate aminotransferase^b (U/L)	26.0 (20.0-35.0)	22.5 (18.3-31.0)	0.027
Alanine aminotransferase^b (U/L)	31.5 (21.3-44.5)	33.0 (18.3-54.0)	0.248
Axillary temperature^b (°C)	36.6 (36.0-37.7)	36.0 (35.6-36.2)	<0.0001*
Platelets^b (platelets/µL)	104,500 (67,650-175,00)	263,500 (230,000-354,500)	<0.0001*
C reactive protein^b (mg/dL)	73.9 (39.6-112.3)	6.7 (3.9-9.4)	<0.0001*
Total proteins^a (g/dL)	6.7 (0.6)	7.2 (0.5)	<0.0001*
Albumin^b (g/dL)	3.90 (3.60-4.20)	4.10 (3.80-4.30)	0.0006*
Uric acid^a (mg/dL)	4.5 (1.16)	5.2 (1.3)	<0.0001*

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[1] Corresponding author: Luciano Teixeira Gomes. e-mail:luteigo@gmail.com