Assorted copper pennies on a scar - a case of chromoblastomycosis after knee transplant

A 44-year-old man who had undergone renal transplantation and on immunosuppressants (tacrolimus) presented with asymptomatic thick hyperpigmented lesions over the right knee for one month (Figure 1). He underwent knee transplant surgery 1.5 months back, after which the lesions started and progressively increased in size. Local examination revealed multiple well-defined skin-colored to hyperpigmented verrucous plaques and nodules with superficial crusts over the right knee at the scar site. Skin scraping with 10% potassium hydroxide (KOH) showed multiple round thick-walled brownish budding bodies resembling different morphologies of copper pennies (also known as sclerotic/muriform/medlar bodies) (Figure 2). An incision biopsy of the lesion showed pseudoepitheliomatous hyperplasia with dermal suppurative granulomas and copper penny bodies, suggestive of chromoblastomycosis (Figure 3). After discussion with the treating nephrologist, he was started on treatment with itraconazole 100 mg twice daily along with cryotherapy¹, following which the lesions started to improve, and he is currently undergoing regular follow-up.

FIGURE 1:
Multiple verrucous plaques with crusting over knee transplant surgery scar.

FIGURE 2:
Various morphologies of copper pennies on KOH smear.

FIGURE 3:
Histopathology showing copper penny bodies of chromoblastomycosis (Hematoxylin & Eosin, 400x).

Chromoblastomycosis, a chronic subcutaneous fungal infection, is caused by pigmented fungi such as Phialophora verrucosa, Fonsecaea pedrosoi, Fonsecaea compacta, and Cladophialophora carrionii². Combined histopathological and mycological diagnosis, including a KOH smear, is a highly sensitive approach³. An interesting feature noted in our case was the various unique morphologies of the copper pennies identified on the KOH smear. This highlights that a simple and inexpensive office procedure can allow timely diagnosis and early treatment of this subcutaneous mycosis, thereby preventing subsequent complications.

ACKNOWLEDGMENTS

None.

REFERENCES

• ¹
  Ranawaka RR, Amarasinghe N, Hewage D. Chromoblastomycosis: combined treatment with pulsed itraconazole therapy and liquid nitrogen cryotherapy. Int J Dermatol. 2009;48(4):397-400.
• ²
  Chandran V, Sadanandan SM, Sobhanakumari K. Chromoblastomycosis in kerala, India. Indian Journal of Dermatology, Venereology & Leprology. 2012;78(6).
• ³
  Raj HJ, Majumdar B, Jain A, Maiti PK, Chatterjee G. A clinico-mycological study on suspected cases of chromoblastomycosis: challenges in diagnosis and management. Journal of Clinical and Diagnostic Research: JCDR. 2015;9(12): WC01.

• Financial Support: None.

Publication Dates

• Publication in this collection
  25 July 2022
• Date of issue
  2022

History

• Received
  11 Mar 2022
• Accepted
  06 Apr 2022