Primary chemoprophylaxis in the reactivation of Chagas' disease with benznidazole in chronic chagasic patients under immunosuppressive corticosteroid therapy: is there evidence for its recommendation?

There is evidence that trypanosomicide drugs prevent the parasitological reactivation of Chagas' disease in patients under corticosteroid therapy. On the other hand there are few reports of clinical reactivation of this disease associated with the use of these immunosuppressive drugs. Primary chemoprophylaxis with trypanosomicide in this situation should not be recommended before being assessed by a randomized controlled trial.

Chagas' disease; Chemoprophylaxis; Corticosteroids