C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

Cardoso, Anajás da Silva; Cardoso, Renata Oliveira; Carvalho, Danielle Franklin de; Collet, Neusa; Medeiros, Carla Campos Muniz

doi:10.1590/1415-52732014000300002

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Original Articles • Rev. Nutr. 27 (3) • May-Jun 2014 • https://doi.org/10.1590/1415-52732014000300002 copy

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents¹ 1 Article based on the master's thesis of AS CARDOSO intitled "Proteína C-reativa e fatores de risco cardiometabólicos em crianças e adolescentes com excesso de peso". Universidade Estadual da Paraíba; 2012

Proteína C-reativa e fatores de risco cardiometabólicos em crianças e adolescentes sobrepeso ou obesidade

Authorship SCIMAGO INSTITUTIONS RANKINGS

OBJECTIVE:

To investigate the relationship between ultrasensitive C-reactive protein and cardiometabolic risk factors in overweight or obese childrenand adolescents.

METHODS:

Cross-sectional study conducted at the Center for Childhood Obesity in the period from April 2009 to April 2010, involving 185 overweight children and adolescents aged 2 to 18 years. Measures of ultrasensitive C-reactive protein according to age, nutritional status, gender, race, cardiometabolic risk factors (waist circumference, lipid profile, impaired fasting glucose, high blood pressure and presence of insulin resistance) were compared through the Chi-square test and analysis of variance. All analyses were performed using the Statistical Package for the Social Sciences software version 17.0, adopting a significance level of 5%.

RESULTS:

Altered high-density lipoprotein was the most frequent cardiometabolic risk factor, and there was a significant association between altered ultrasensitive C-reactive protein values and severe obesity (p=0.005), high waist circumference (p<0.001), hypertriglyceridemia (p=0.037) and insulin resistance (p=0.002), as well as significantly higher body mass index (p=0.000), waist circumference (p=0.001), insulin (p=0.005) and index of glucose homeostasis values(p=0.005).

CONCLUSION:

High prevalence of altered ultrasensitive C-reactive protein and significant association with severe obesity, waist circumference, hypertriglyceridemia and insulin resistance were observed.

C-reactive protein; Cardiovascular diseases; Obesity; Risk factors

			CRP
Variables
Variables		High			Normal
		High			Normal

	n	%		n		%

Gender						<0.784^*
Male	18	30.0	42			70.0
Female	40	32.0	85			68.0
Age group						<0.388^*
Childhood (2-9 years)	19	27.5	50			72.5
Adolescence (10-18 years)	39	33.6	77			66.4
Nutritional status						<0.005^*
Obesity	55	35.5	100			64.5
Overweight	3	10.0	27			90.0
Income						<0.869^*
=2 MW	31	30.7	70			69.3
>2 MW	22	31.9	47			68.1
WC						<0.001^*
High	56	38.1	91			61.9
Normal	2	5.3	36			94.7
SBP						<0.099^*
SBP =P90	27	38.6	43			61.4
SBP <P90	31	27.0	84			73.0
DBP						<0.919^*
DBP =P90	37	31.1	82			68.9
DBP <P90	21	38.1	45			68.2
TG						<0.037^*
High	29	40.3	43			59.7
Normal	29	25.7	84			74.3
HDL-c						<0.277^*
Reduced	50	33.1	101			66.9
Normal	8	23.5	26			76.5
LDL-c						<0.571^*
High	10	35.7	18			64.3
Normal	47	30.3	108			69.7
TC						<0.659^*
High	22	29.3	53			70.7
Normal	35	32.4	73			67.6
Blood glucose						<1.00^*0
High	1	33.3	2			66.7
Normal	57	31.3	125			68.7
Insulin resistance						<0.002
Present	34	43.6	44			56.4
Absent	23	21.9	82			78.1

			CRP			p
Variables
Variables		High			Normal
		High			Normal

	Mean	SD		Mean	SD

Age (years)	11.48	3.48	011.09		03.78	<0.508
WC (cm)	90.48	12.71	083.61		12.24	<0.001
BMI (kg/m²)	29.38	4.85	026.25		04.02	<0.001
TG (mg/dL)	149.88	78.69	121.53		60.27	<0.008
SBP(mmHg)	111.04	11.02	106.24		11.73	<0.009
DBP (mmHg)	72.94	9.39	072.02		09.80	<0.551
Blood glucose (mg/dL)	82.10	8.27	080.85		07.42	<0.306
Insulin (mg/dL)	14.88	9.53	011.14		07.69	<0.005
HOMA-IR	3.04	1.98	002.26		01.58	<0.005
TC	163.49	39.76	164.06		35.70	<0.923
LDL-c	97.22	30.45	100.40		29.81	<0.505
HDL-c	35.83	7.41	039.30		08.52	<0.008

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[1] CONTRIBUTORS AS CARDOSO participation in project design, data analysis and final review of the manuscript. RO OLIVEIRA formatting and final review of the manuscript. DF CARVALHO final review of the manuscript. N COLLET final review of the manuscript. CCM MEDEIROS participation in project design, data analysis and final review of the manuscript.