Manifestaciones sintomáticas de la enfermedad causada por coronavirus (COVID-19) en adultos: revisión sistemática

Sousa Neto, Antonio Rosa de; Carvalho, Ana Raquel Batista de; Oliveira, Erika Morganna Neves de; Magalhães, Rosilane de Lima Brito; Moura, Maria Eliete Batista; Freitas, Daniela Reis Joaquim de

Antonio Rosa de Sousa Neto

Universidade Federal do Piauí (UFPI), Departamento de Enfermagem. Teresina, Piauí, Brasil.

http://orcid.org/0000-0002-0675-0916

Ana Raquel Batista de Carvalho

Universidade Federal do Piauí (UFPI), Departamento de Enfermagem, Programa de Pós-Graduação em Enfermagem. Teresina, Piauí, Brasil.

http://orcid.org/0000-0001-5287-1084

Erika Morganna Neves de Oliveira

Universidade Federal do Piauí (UFPI), Departamento de Enfermagem, Programa de Pós-Graduação em Enfermagem. Teresina, Piauí, Brasil.

http://orcid.org/0000-0001-8588-6290

Rosilane de Lima Brito Magalhães

Universidade Federal do Piauí (UFPI), Departamento de Enfermagem, Programa de Pós-Graduação em Enfermagem. Teresina, Piauí, Brasil.

Universidade Federal do Piauí (UFPI), Colégio Técnico de Teresina. Teresina, Piauí, Brasil.

http://orcid.org/0000-0001-9695-1350

Maria Eliete Batista Moura

Universidade Federal do Piauí (UFPI), Departamento de Enfermagem, Programa de Pós-Graduação em Enfermagem. Teresina, Piauí, Brasil.

http://orcid.org/0000-0003-3095-9506

Daniela Reis Joaquim de Freitas

Universidade Federal do Piauí (UFPI), Departamento de Enfermagem, Programa de Pós-Graduação em Enfermagem. Teresina, Piauí, Brasil.

Universidade Federal do Piauí (UFPI), Departamento de Parasitologia e Microbiologia. Teresina, Piauí, Brasil.

http://orcid.org/0000-0002-5632-0332

Corresponding author
Antonio Rosa de Sousa Neto E-mail: antonioneto@ufpi.edu.br

Authorship contributions

Conceptualization: Antonio Rosa de Sousa Neto. Methodology: Antonio Rosa de Sousa Neto, Daniela Reis Joaquim de Freitas. Supervision: Daniela Reis Joaquim de Freitas. Writing - original draft: Antonio Rosa de Sousa Neto, Ana Raquel Batista de Carvalho, Erika Morganna Neves de Oliveira. Writing - proofreading and editing: Daniela Reis Joaquim de Freitas, Rosilane de Lima Brito Magalhães, Maria Eliete Batista Moura.

Associate editor

Dagmar Elaine Kaiser

Editor-in-chief

Maria da Graça Oliveira Crossetti

Order	Author/ Year/Country	Periodical/ Database	Title/ Publication language	Type of study/ Level of Evidence	No. and average age of participants
A1 17 17. Du W, Yu J, Wang H, Zhang X, Zhang S, Li Q, et al. Clinical characteristics of COVID-19 in children compared with adults in Shandong Province, China. Infection. 2020;48:445-52. doi: https://doi.org/10.1007/s15010-020-01427-2 https://doi.org/10.1007/s15010-020-01427...	Du W et al., 202017. Du W, Yu J, Wang H, Zhang X, Zhang S, Li Q, et al. Clinical characteristics of COVID-19 in children compared with adults in Shandong Province, China. Infection. 2020;48:445-52. doi: https://doi.org/10.1007/s15010-020-01427-2 https://doi.org/10.1007/s15010-020-01427... , China	Infection/ PubMed	Clinical characteristics of COVID-19 in children compared with adults in Shandong Province, China/ Inglês	Retrospective Cross-Sectional Study / Low	53 (41,47)
A2 18 18. Li R, Tian J, Yang F, Lv L, Yu J, Sun G, et al. Clinical characteristics of 225 patients with COVID-19 in a tertiary Hospital near Wuhan, China. J Clin Virol. 2020;127:104363. doi: https://doi.org/10.1016/j.jcv.2020.104363 https://doi.org/10.1016/j.jcv.2020.10436...	Li R et al., 202035. Li X, Zai J, Wang X, Li Y. Potential of large "first generation" human-to-human transmission of 2019-nCoV. J Med Virol. 2020;92(4):448-54. doi: https://doi.org/10.1002/jmv.25693 https://doi.org/10.1002/jmv.25693... , China	J Clin Virol/ PubMed	Clinical characteristics of 225 patients with COVID-19 in a tertiary Hospital near Wuhan, China/ Inglês	Retrospective Cross-Sectional Study / Moderate	225 (50 ± 14)
A3 19 19. Sun C, Zhang XB, Dai Y, Xu XZ, Zhao J. [Clinical analysis of 150 cases of 2019 novel coronavirus infection in Nanyang City, Henan Province]. Zhonghua Jie He He Hu Xi Za Zhi. 2020;43(6):503-8. Chinese. doi: http://doi.org/10.3760/cma.j.cn112147-20200224-00168 http://doi.org/10.3760/cma.j.cn112147-20...	Sun C et al., 202019. Sun C, Zhang XB, Dai Y, Xu XZ, Zhao J. [Clinical analysis of 150 cases of 2019 novel coronavirus infection in Nanyang City, Henan Province]. Zhonghua Jie He He Hu Xi Za Zhi. 2020;43(6):503-8. Chinese. doi: http://doi.org/10.3760/cma.j.cn112147-20200224-00168 http://doi.org/10.3760/cma.j.cn112147-20... , China	Zhonghua Jie He He Hu Xi Za Zhi/ PubMed	Clinical analysis of 150 cases of 2019 novel coronavirus infection in Nanyang City, Henan Province/ Chinês	Retrospective Cross-Sectional Study / Moderate	150 (45 ± 16)
A4 20 20. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020;77(6):683-90. doi: https://doi.org/10.1001/jamaneurol.2020.1127 https://doi.org/10.1001/jamaneurol.2020....	Mao L et al. 202020. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020;77(6):683-90. doi: https://doi.org/10.1001/jamaneurol.2020.1127 https://doi.org/10.1001/jamaneurol.2020.... , China	JAMA Neurol/ PubMed	Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China/ Inglês	Retrospective Cross-Sectional Study / Moderate	214 (52,7 ± 15,5)
A5 21 21. Peng L, Liu KY, Xue F, Miao YF, Tu PA, Zhou C. Improved early recognition of coronavirus disease-2019 (COVID-19): single-center data from a Shanghai screening hospital. Arch Iran Med. 2020;23(4):272-6. doi: https://doi.org/10.34172/aim.2020.10 https://doi.org/10.34172/aim.2020.10...	Peng L et al. 202021. Peng L, Liu KY, Xue F, Miao YF, Tu PA, Zhou C. Improved early recognition of coronavirus disease-2019 (COVID-19): single-center data from a Shanghai screening hospital. Arch Iran Med. 2020;23(4):272-6. doi: https://doi.org/10.34172/aim.2020.10 https://doi.org/10.34172/aim.2020.10... , China	Arch Iran Med/ PubMed e Web of Science	Improved Early Recognition of Coronavirus Disease-2019 (COVID-19): Single-Center Data from a Shanghai Screening Hospital/ Inglês	Retrospective Cross-Sectional Study / Very low	11 (40,73 ± 11,32)
A6 22 22. Wang X, Fang J, Zhu Y, Chen L, Ding F, Zhou R, et al. Clinical characteristics of non-critically ill patients with novel coronavirus infection (COVID-19) in a Fangcang Hospital. Clin Microbiol Infect. 2020;26(8):1063-8. doi: https://doi.org/10.1016/j.cmi.2020.03.032 https://doi.org/10.1016/j.cmi.2020.03.03...	Wang X et al. 202022. Wang X, Fang J, Zhu Y, Chen L, Ding F, Zhou R, et al. Clinical characteristics of non-critically ill patients with novel coronavirus infection (COVID-19) in a Fangcang Hospital. Clin Microbiol Infect. 2020;26(8):1063-8. doi: https://doi.org/10.1016/j.cmi.2020.03.032 https://doi.org/10.1016/j.cmi.2020.03.03... , China	Clin Microbiol Infect/ PubMed e Scopus	Clinical characteristics of non-critically ill patients with novel coronavirus infection (COVID-19) in a Fangcang Hospital/ Inglês	Retrospective Cross-sectional study/ Moderate	1012 (50)
A7 23 23. Liu M, He P, Liu HG, Wang XJ, Li FJ, Chen S, et al. [Clinical characteristics of 30 medical workers infected with new coronavirus pneumonia]. Zhonghua Jie He He Hu Xi Za Zhi. 2020; 43(3):209-14. Chinese. doi: https://doi.org/10.3760/cma.j.issn.1001-0939.2020.03.014 https://doi.org/10.3760/cma.j.issn.1001-...	Liu M et al. 202035. Li X, Zai J, Wang X, Li Y. Potential of large "first generation" human-to-human transmission of 2019-nCoV. J Med Virol. 2020;92(4):448-54. doi: https://doi.org/10.1002/jmv.25693 https://doi.org/10.1002/jmv.25693... , China	Zhonghua Jie He He Hu Xi Za Zhi/ PubMed	Clinical characteristics of 30 medical workers infected with new coronavirus pneumonia/ Chinês	Retrospective Cross-Sectional Study / Low	30 (35 ± 8)
A8 24 24. Wu J, Liu J, Zhao X, Liu C, Wang W, Wang D, et al. Clinical characteristics of imported cases of COVID-19 in Jiangsu Province: a multicenter descriptive study. Clin Infect Dis. 2020;71(15):706-12. doi: https://doi.org/10.1093/cid/ciaa199 https://doi.org/10.1093/cid/ciaa199...	Wu J et al. 202026. Wu J, Wu X, Zeng W, Guo D, Fang Z, Chen L, et al. Chest CT findings in patients with coronavirus disease 2019 and its relationship with clinical features. Invest Radiol. 2020;55(5):257-61. doi: https://doi.org/10.1097/RLI.0000000000000670 https://doi.org/10.1097/RLI.000000000000... , China	Clin Infect Dis/ PubMed	Clinical Characteristics of Imported Cases of COVID-19 in Jiangsu Province: A Multicenter Descriptive Study/ Inglês	Retrospective Cross-Sectional Study / Moderate	80 (46,10 ± 15,42)
A9 25 25. Xu X, Yu C, Qu J, Zhang L, Jiang S, Huang D, et al. Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2. Eur J Nucl Med Mol Imaging. 2020;47(5):1275-80. doi: https://doi.org/10.1007/s00259-020-04735-9 https://doi.org/10.1007/s00259-020-04735...	Xu X et al. 202025. Xu X, Yu C, Qu J, Zhang L, Jiang S, Huang D, et al. Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2. Eur J Nucl Med Mol Imaging. 2020;47(5):1275-80. doi: https://doi.org/10.1007/s00259-020-04735-9 https://doi.org/10.1007/s00259-020-04735... , China	Eur J Nucl Med Mol Imaging/ PubMed	Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2/ Inglês	Retrospective Cross-Sectional Study / Low	90 (50)
A10 26 26. Wu J, Wu X, Zeng W, Guo D, Fang Z, Chen L, et al. Chest CT findings in patients with coronavirus disease 2019 and its relationship with clinical features. Invest Radiol. 2020;55(5):257-61. doi: https://doi.org/10.1097/RLI.0000000000000670 https://doi.org/10.1097/RLI.000000000000...	Wu J et al. 202026. Wu J, Wu X, Zeng W, Guo D, Fang Z, Chen L, et al. Chest CT findings in patients with coronavirus disease 2019 and its relationship with clinical features. Invest Radiol. 2020;55(5):257-61. doi: https://doi.org/10.1097/RLI.0000000000000670 https://doi.org/10.1097/RLI.000000000000... , China	Invest Radiol/ PubMed e Scopus	Chest CT Findings in Patients With Coronavirus Disease 2019 and Its Relationship With Clinical Features/ Inglês	Retrospective Cross-Sectional Study / Low	80 (44 ± 11)
A11 27 27. Zhang JJ, Dong X, Cao YY, Yuan YD, Yang YB, Yan YQ, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. 2020;75:1730-41. doi: https://doi.org/10.1111/all.14238 https://doi.org/10.1111/all.14238...	Zhang JJ et al. 202027. Zhang JJ, Dong X, Cao YY, Yuan YD, Yang YB, Yan YQ, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. 2020;75:1730-41. doi: https://doi.org/10.1111/all.14238 https://doi.org/10.1111/all.14238... , China	Allergy/ PubMed e Scopus	Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China/ Inglês	Retrospective Cross-Sectional Study / Moderate	140 (57)
A12 28 28. Liu K, Fang YY, Deng Y, Liu W, Wang MF, Ma JP, et al. Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chin Med J (Engl). 2020;133(9):1025-31. doi: https://doi.org/10.1097/CM9.0000000000000744 https://doi.org/10.1097/CM9.000000000000...	Liu K et al. 202035. Li X, Zai J, Wang X, Li Y. Potential of large "first generation" human-to-human transmission of 2019-nCoV. J Med Virol. 2020;92(4):448-54. doi: https://doi.org/10.1002/jmv.25693 https://doi.org/10.1002/jmv.25693... , China	Chin Med J (Engl)/ PubMed	Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province/ Inglês	Retrospective Cross-Sectional Study / Moderate	137 (55 ± 16)
A13 29 29. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-13. doi: https://doi.org/10.1016/S0140-6736(20)30211-7 https://doi.org/10.1016/S0140-6736(20)30...	Chen N et al. 202029. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-13. doi: https://doi.org/10.1016/S0140-6736(20)30211-7 https://doi.org/10.1016/S0140-6736(20)30... , China	Lancet/ PubMed	Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study/ Inglês	Retrospective Cross-Sectional Study / Moderate	99 (55,5 ± 13,1)

Order	Main Results
A1 17 17. Du W, Yu J, Wang H, Zhang X, Zhang S, Li Q, et al. Clinical characteristics of COVID-19 in children compared with adults in Shandong Province, China. Infection. 2020;48:445-52. doi: https://doi.org/10.1007/s15010-020-01427-2 https://doi.org/10.1007/s15010-020-01427...	Regarding the clinical type: mild (15.1%), moderate (83%), severe (1.9%), critical (0%). Most common symptoms: fever (60.4%) and normal or dry cough (54.7%). Less common symptoms: sputum or expectoration (37.7%), pharyngalgia (35.8%), fatigue (32.1%), headache (20.8%), anorexia (15.1%), myalgia (13.2%), anxiety or chest pain (11.3%), nausea (5.7%), diarrhea (3.8%), dizziness (3.8%) and vomiting (1.9%).
A2 18 18. Li R, Tian J, Yang F, Lv L, Yu J, Sun G, et al. Clinical characteristics of 225 patients with COVID-19 in a tertiary Hospital near Wuhan, China. J Clin Virol. 2020;127:104363. doi: https://doi.org/10.1016/j.jcv.2020.104363 https://doi.org/10.1016/j.jcv.2020.10436...	Regarding the clinical type: severe (16.44%). Most common symptoms: fever (84.44%) and normal or dry cough (56.44%). Less common symptoms: dyspnea (4.00%), sputum or expectoration, fatigue, chills, headache, anxiety or chest pain and pharyngalgia (3.56% to 22.67%).
A3 19 19. Sun C, Zhang XB, Dai Y, Xu XZ, Zhao J. [Clinical analysis of 150 cases of 2019 novel coronavirus infection in Nanyang City, Henan Province]. Zhonghua Jie He He Hu Xi Za Zhi. 2020;43(6):503-8. Chinese. doi: http://doi.org/10.3760/cma.j.cn112147-20200224-00168 http://doi.org/10.3760/cma.j.cn112147-20...	Regarding the clinical type: mild (4%), moderate (70%), severe (19%), critical (7%). Most common symptoms: fever (95%), normal/dry cough and sputum/expectoration (72%), fatigue (15%), anorexia (13%), asthma and dyspnea (10%). Less common symptoms: myalgia (4%), pharyngalgia (8%), headache (2%) and diarrhea (1%).
A4 20 20. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020;77(6):683-90. doi: https://doi.org/10.1001/jamaneurol.2020.1127 https://doi.org/10.1001/jamaneurol.2020....	Regarding the clinical type: not severe (58.9%) and severe (41.1%). Most common symptoms: fever (61.7%) and normal or dry cough (50.0%). Less common symptoms: anorexia (31.8%), pharyngalgia (14.5%) and abdominal pain (4.7%). neurological manifestations were considered separately: Central Nervous System (CNS). The most common symptoms reported were dizziness (16.8%) and headache (13.1%). Regarding the Peripheral Nervous System (SNP) the most prevalent symptoms were taste disorder (5.6%) and smell disorder (5.1%).
A5 21 21. Peng L, Liu KY, Xue F, Miao YF, Tu PA, Zhou C. Improved early recognition of coronavirus disease-2019 (COVID-19): single-center data from a Shanghai screening hospital. Arch Iran Med. 2020;23(4):272-6. doi: https://doi.org/10.34172/aim.2020.10 https://doi.org/10.34172/aim.2020.10...	No distinction was made as to the type of patient impairment. The most common symptoms were fever (91%), systemic pain (64%), normal or dry cough (55%). A less common symptom reported was pharyngalgia (9%).
A6 22 22. Wang X, Fang J, Zhu Y, Chen L, Ding F, Zhou R, et al. Clinical characteristics of non-critically ill patients with novel coronavirus infection (COVID-19) in a Fangcang Hospital. Clin Microbiol Infect. 2020;26(8):1063-8. doi: https://doi.org/10.1016/j.cmi.2020.03.032 https://doi.org/10.1016/j.cmi.2020.03.03...	No distinction was made as to the type of patient impairment. It was only reported that the 1,012 individuals were not critical patients. Most common symptoms: fever (75.2%) and normal or dry cough (52.4%). Less common symptoms: dyspnea (22.8%), sputum or expectoration (21.7%), chills (18.0%), myalgia (16.8%), headache (15.0%), diarrhea (15.0%), pharyngalgia (14.2%), nasal congestion (6.9%), rhinorrhea or runny nose (5.6%), vomiting (3.6%) and abdominal pain (3.7%).
A7 23 23. Liu M, He P, Liu HG, Wang XJ, Li FJ, Chen S, et al. [Clinical characteristics of 30 medical workers infected with new coronavirus pneumonia]. Zhonghua Jie He He Hu Xi Za Zhi. 2020; 43(3):209-14. Chinese. doi: https://doi.org/10.3760/cma.j.issn.1001-0939.2020.03.014 https://doi.org/10.3760/cma.j.issn.1001-...	Regarding the clinical type: moderate (86.67%) and severe (13.34%). Most common symptoms: normal or dry cough (83.33%), fever (76.67%), fatigue or systemic pain (70%) and headache (53.33%). Less common symptoms: dyspnea (46.67%) and gastrointestinal symptoms like nausea, vomiting or diarrhea (30%).
A8 24 24. Wu J, Liu J, Zhao X, Liu C, Wang W, Wang D, et al. Clinical characteristics of imported cases of COVID-19 in Jiangsu Province: a multicenter descriptive study. Clin Infect Dis. 2020;71(15):706-12. doi: https://doi.org/10.1093/cid/ciaa199 https://doi.org/10.1093/cid/ciaa199...	Regarding the clinical type: mild (35.00%), moderate (61.25%), severe (3.75%), critical (0%). Most common symptoms: fever (78.75%) and normal or dry cough (63.75%). Less common symptoms: dyspnea (37.50%), myalgia (22.50%), headache or mental confusion (16.25%), pharyngalgia (13.75%), rhinorrhea, nasal congestion or runny nose (6.10%), anxiety or chest pain (3.75%), diarrhea (1.25), nausea or vomiting (1.25%). The occurrence of more than one symptom (82.50%) was also assessed.
A9 25 25. Xu X, Yu C, Qu J, Zhang L, Jiang S, Huang D, et al. Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2. Eur J Nucl Med Mol Imaging. 2020;47(5):1275-80. doi: https://doi.org/10.1007/s00259-020-04735-9 https://doi.org/10.1007/s00259-020-04735...	No distinction was made as to the type of patient impairment. Most common symptoms: fever (78%) and normal or dry cough (63%). Less common symptoms: sputum or expectoration (12%), fatigue (21%), myalgia (28%), pharyngalgia (26%), chills (7%), headache (4%), diarrhea (6%), nausea (6%) and vomiting (2%). The absence of obvious symptoms (7%) was also assessed.
A10 26 26. Wu J, Wu X, Zeng W, Guo D, Fang Z, Chen L, et al. Chest CT findings in patients with coronavirus disease 2019 and its relationship with clinical features. Invest Radiol. 2020;55(5):257-61. doi: https://doi.org/10.1097/RLI.0000000000000670 https://doi.org/10.1097/RLI.000000000000...	No distinction was made as to the type of patient impairment. Most common symptoms: fever (76%) and normal or dry cough (73%). Less common symptoms: myalgia (16%), sputum or expectoration (14%), pharyngalgia (11%), dizziness or headache (10%), abdominal pain or diarrhea (9%), dyspnea (9%), anxiety or chest pain (6%) and hemoptysis (4%).
A11 27 27. Zhang JJ, Dong X, Cao YY, Yuan YD, Yang YB, Yan YQ, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. 2020;75:1730-41. doi: https://doi.org/10.1111/all.14238 https://doi.org/10.1111/all.14238...	Regarding the clinical type: mild or conventional (58.57%) and severe (41.42). Most common symptoms: fever (91.7%), normal or dry cough (75%) and fatigue (75%). Less common symptoms: anxiety or chest pain, or dyspnea (36.7%), gastrointestinal symptoms (39.6%), including nausea (17.3%), diarrhea (12.9%), anorexia (12%), abdominal pain (5.8%), belching (5.0%) and vomiting (5.0%).
A12 28 28. Liu K, Fang YY, Deng Y, Liu W, Wang MF, Ma JP, et al. Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chin Med J (Engl). 2020;133(9):1025-31. doi: https://doi.org/10.1097/CM9.0000000000000744 https://doi.org/10.1097/CM9.000000000000...	No distinction was made as to the type of patient impairment. Most common symptoms: fever (81.8%), normal or dry cough (48.2%). Less common symptoms: myalgia or fatigue (32.1%), dyspnea (19.0%), headache (9.5%), diarrhea (8.0%), tachycardia (7.3%), hemoptysis (5.1%) and sputum or expectoration (4.4%).
A13 29 29. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-13. doi: https://doi.org/10.1016/S0140-6736(20)30211-7 https://doi.org/10.1016/S0140-6736(20)30...	No distinction was made as to the type of patient impairment. Most common symptoms: fever (83%) and normal or dry cough (82%). Less common symptoms: dyspnea (31%), myalgia (11%), mental confusion (9%), headache (8%), pharyngalgia (5%), rhinorrhea, nasal congestion or runny nose (4%), anxiety or chest pain (2%), diarrhea (2%) and vomiting (1%). The occurrence of more than one symptom (90%) was also assessed.

[1] Corresponding author
Antonio Rosa de Sousa Neto E-mail: antonioneto@ufpi.edu.br

Brasil

Brasil

Manifestaciones sintomáticas de la enfermedad causada por coronavirus (COVID-19) en adultos: revisión sistemática

RESUMEN

Objetivo

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Resultados

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