Efectividad de las vacunas en la prevención de la muerte por síndrome respiratório agudo grave por covid-19 en Blumenau, Brasil, 2021

Renck, Emanuelle; Zipper, Caroline Beatriz; Fabrino Junior, Marcio Rodrigues; Salgado, Luisa Andrea Torres; Rowe, Adriel; Helena, Ernani Tiaraju de Santa

Emanuelle Renck

collaborated with the study conception and design

analysis and interpretation of the results

drafting and critical reviewing of the manuscript content

Universidade Regional de Blumenau, Departamento de Medicina, Blumenau, SC, Brasil

http://orcid.org/0000-0001-8101-513X

Caroline Beatriz Zipper

collaborated with the study conception and design

analysis and interpretation of the results

drafting and critical reviewing of the manuscript content

Universidade Regional de Blumenau, Departamento de Medicina, Blumenau, SC, Brasil

http://orcid.org/0000-0003-1038-1700

Marcio Rodrigues Fabrino Junior

conception, design and critical reviewing of the manuscript content

approved the final version of the manuscript and declared themselves to be responsible for all aspects of the work

including ensuring its accuracy and integrity

Universidade Regional de Blumenau, Departamento de Medicina, Blumenau, SC, Brasil

Universidade Regional de Blumenau, Programa de Pós-Graduação em Saúde Coletiva, Blumenau, SC, Brazil

http://orcid.org/0000-0002-7611-9775

Luisa Andrea Torres Salgado

collaborated with the study conception and design

analysis and interpretation of the results

drafting and critical reviewing of the manuscript content

approved the final version of the manuscript and declared themselves to be responsible for all aspects of the work

including ensuring its accuracy and integrity

Prefeitura de Blumenau, Secretaria de Promoção da Saúde, Blumenau, SC, Brazil

http://orcid.org/0000-0003-2963-646X

Adriel Rowe

conception, design and critical reviewing of the manuscript content

approved the final version of the manuscript and declared themselves to be responsible for all aspects of the work

including ensuring its accuracy and integrity

Prefeitura de Blumenau, Secretaria de Promoção da Saúde, Blumenau, SC, Brazil

http://orcid.org/0000-0002-6110-460X

Ernani Tiaraju de Santa Helena

collaborated with the study conception and design

analysis and interpretation of the results

drafting and critical reviewing of the manuscript content

Universidade Regional de Blumenau, Departamento de Medicina, Blumenau, SC, Brasil

Universidade Regional de Blumenau, Programa de Pós-Graduação em Saúde Coletiva, Blumenau, SC, Brazil

http://orcid.org/0000-0002-1337-6723

Correspondence: Emanuelle Renck | emanuelle.renck@gmail.com

CONFLICTS OF INTEREST

The authors declare that there is no conflict of interest.

Associate editor:

Paola Barbosa Marchesini

Variables	Total n (%)	Cases n (%)	Controls n (%)	p-value^a
Sex (n = 1,756)
Female	716 (40.8)	179 (45.0)	537 (39.5)
Male	1,040 (59.2)	219 (55.0)	821 (60.5)	0.050
Age group in years (n = 1,756)
20-59	1,034 (58.9)	126 (31.7)	908 (66.9)
60-79	572 (32.6)	189 (47.5)	383 (28.2)
≥ 80	150 (8.5)	83 (20.8)	67 (4.9)	< 0.001
Race/skin color (n = 1 ,723)
White	1,624 (94.3)	373 (94.4)	1,251 (94.2)
Non-White	99 (5.7)	22 (5.6)	77 (5.8)	0.864
Schooling (n = 1,667)
Higher education	327 (19.6)	35 (9.2)	292 (22.7)
High school	500 (30.0)	84 (22.1)	416 (32.3)
Illiterate/elementary education	840 (50.4)	261 (68.7)	579 (45.0)	< 0.001
Grouped neighborhoods (n = 1,748)
Without any plots	378 (21.6)	83 (21.0)	295 (21.8)
Up to 10 agricultural plots	810 (46.4)	165 (41.7)	645 (47.7)
More than 10 agricultural plots	560 (32.0)	148 (37.3)	412 (30.5)	0.029
Presen ce of comorbidities (n = 1,756)
No	555 (31.6)	25 (6.3)	530 (39.0)
Yes	1,201 (68.4)	373 (93.7)	828 (61.0)	< 0.001
Number of comorbidities (n = 1,713)
None	555 (32.4)	25 (6.4)	530 (40.0)
One	468 (27.3)	90 (23.1)	378 (28.6)
Two	413 (24.1)	139 (35.7)	274 (20.7)
Three or more	277 (16.2)	135 (34.7)	142 (10.7)	< 0.001
Influenza vaccine in the last campaign (n = 1,685)
No	993 (58.9)	182 (47.0)	811 (62.5)
Yes	692 (41.1)	205 (53.0)	487 (37.5)	< 0.001
ICU admission^b (n = 1,730)
No	1,054 (60.9)	107 (28.2))	947 (70.1)
Yes	676 (39.1)	272 (71.8)	404 (29.9)	< 0.001
Number of doses of COVID-19 vaccine
One	38.5%	30.2%	40.9%	< 0.001
Two or a single dose	27.3%	18.6%	29.8%	< 0.001

Vaccination schedule (number of doses)	Total (n = 1,756)		Age group (in years)
	Total (n = 1,756)		20 to 59 (n = 1,034)		60 and older (n = 722)
	OR crude (95%CI )	OR adjusted ^a (95%CI)	OR crude (95%CI)	OR adjusted ^a (95%CI)	OR crude (95%CI)	OR ad justed ^a (95%CI)
One	0.62 (0.48;0.79)	0.27 (0.20;0.38)	0.26 (0.15;0.47)	0.23 (0.12;0.43)	0.45 (0.33;0.61)	0.25 (0.17;0.37)
Two or a single dose	0.53 (0.40;0.71)	0.23 (0.16;0.33)	0.09 (0.03;0.28)	0.11 (0.03;0.35)	0.40 (0.29;0.56)	0.22 (0.15;0.34)

[1] Correspondence: Emanuelle Renck | emanuelle.renck@gmail.com

Brasil

Brasil

Efectividad de las vacunas en la prevención de la muerte por síndrome respiratório agudo grave por covid-19 en Blumenau, Brasil, 2021

RESUMEN

Objetivo

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Conclusión