Description of the first cases of Zika virus fever investigated in municipalities of the Brazilian Northeastern Region, 2015

to confirm Zika virus circulation and discard other etiological agents in an outbreak occurred in the states of Rio Grande do Norte, Maranhão and Paraíba, in May, 2015.

METHODS:

this is a case series descriptive study with residents in Natal-RN, Barra do Corda-MA, São Luis-MA and João Pessoa-PB, with 20 cases in each state, presenting rash, absent or mild fever and one of the following signs/symptoms: conjunctival hyperemia, arthralgia or limb edema; RT-PCR/isolation tests for Zika, enterovirus and respiratory viruses, and serology tests (dengue, rubella and parvovirus B19) were performed.

RESULTS:

the main symptoms were rash (n=60), pruritus (n=54), and arthralgia (n=47); 51 individuals did not present fever; Zika virus was identified in 18 cases (12 in Paraíba, four in Maranhão and two in Rio Grande do Norte), and antibodies to dengue, in 14 cases.

CONCLUSION:

the symptoms were consistent with Zika virus fever; there was laboratory confirmation for Zika and dengue.

Keywords:
Exanthema; Arboviruses; Zika Virus; Zika Virus Infection; Epidemiology, Descriptive

Authorship

Francieli Fontana Sutile Tardetti Fantinato

Ministério da Saúde, Secretaria de Vigilância em Saúde, Brasília-DF, BrasilMinistério da SaúdeBrazilBrasília, DF, BrazilMinistério da Saúde, Secretaria de Vigilância em Saúde, Brasília-DF, Brasil

Emerson Luiz Lima Araújo

Igor Gonçalves Ribeiro

Marcia Regina de Andrade

Anna Livia de Medeiros Dantas

Secretaria de Estado da Saúde Pública do Rio Grande do Norte, Secretaria de Vigilância em Saúde, Natal-RN, BrasilSecretaria de Estado da Saúde Pública do Rio Grande do NorteBrasilNatal, RN, BrasilSecretaria de Estado da Saúde Pública do Rio Grande do Norte, Secretaria de Vigilância em Saúde, Natal-RN, Brasil

Jakeline Maria Trinta Rios

Secretaria de Estado da Saúde do Maranhão, Centro de Informações Estratégicas em Vigilância em Saúde, São Luís-MA, BrasilSecretaria de Estado da Saúde do MaranhãoBrasilSão Luís, MA, BrasilSecretaria de Estado da Saúde do Maranhão, Centro de Informações Estratégicas em Vigilância em Saúde, São Luís-MA, Brasil

Odila Márcia Vinhas da Silva

Secretaria Municipal de Saúde de Barra do Corda, Vigilância Epidemiológica, Barra do Corda-MA, BrasilSecretaria Municipal de Saúde de Barra do CordaBrazilBarra do Corda, MA, BrazilSecretaria Municipal de Saúde de Barra do Corda, Vigilância Epidemiológica, Barra do Corda-MA, Brasil

Maria do Socorro da Silva

Secretaria Municipal de Saúde de São Luís, Coordenação de Vigilância Epidemiológica da Dengue e Chikungunya, São Luís-MA, BrasilSecretaria Municipal de Saúde de São LuísBrazilSão Luís, MA, BrazilSecretaria Municipal de Saúde de São Luís, Coordenação de Vigilância Epidemiológica da Dengue e Chikungunya, São Luís-MA, Brasil

Renata Valeria Nóbrega

Secretaria de Estado da Saúde da Paraíba, Coordenação-Geral de Vigilância em Saúde, João Pessoa-PB, BrasilSecretaria de Estado da Saúde da ParaíbaBrasilJoão Pessoa, PB, BrasilSecretaria de Estado da Saúde da Paraíba, Coordenação-Geral de Vigilância em Saúde, João Pessoa-PB, Brasil

Daniel de Araújo Batista

Secretaria Municipal de Saúde de João Pessoa, Coordenação de Vigilância Epidemiológica, João Pessoa-PB, BrasilSecretaria Municipal de Saúde de João PessoaBrazilJoão Pessoa, PB, BrazilSecretaria Municipal de Saúde de João Pessoa, Coordenação de Vigilância Epidemiológica, João Pessoa-PB, Brasil

Priscila Leal e Leite

Eduardo Saad

Jadher Percio

Elionardo Andrade Resende

Priscila Bochi de Souza

Marcelo Yoshito Wada

All the authors contributed to the study design, development of the questionnaire, collection, analysis and interpretation of data and drafting of the intellectual content of the manuscript.

All the authors have approved the final version of the manuscript and are responsible for all the work aspects, ensuring its accuracy and integrity.

SCIMAGO INSTITUTIONS RANKINGS

Tables

Tables (5)

Thumbnail

Table 1 -
Distribution of exanthematous syndrome cases, according to age group, in the municipalities of Natal-RN^a, Barra do Corda-MA^b, São Luís-MA^b, and João Pessoa-PB^c, May, 2015

Thumbnail

Table 2 -
Distribution of exanthematous syndrome cases, according to its appearance in comparison to the other symptoms, part of the body where it began and type, in the municipalities of Natal-RN^a, Barra do Corda-MA^b, São Luís-MA^b, and João Pessoa-PB^c, May, 2015

Thumbnail

Table 3 -
Characterization of exanthematous syndrome cases, according to signs and symptoms, in the municipalities of Natal-RN^a, Barra do Corda-MA^b, São Luís-MA^b, and João Pessoa-PB^c, May, 2015

Thumbnail

Table 4 -
Distribution of exanthematous syndrome cases, according to part of the body of joint pain, in the municipalities Natal-RN^a, Barra do Corda-MA^b, São Luís-MA^b, and João Pessoa-PB^c, May, 2015

Thumbnail

Table 5 -
Distribution of exanthematous syndrome cases, according to platelets and white blood cells count, in the municipalities of Natal-RN^a and João Pessoa-PB^b, May, 2015

Table 1 - Distribution of exanthematous syndrome cases, according to age group, in the municipalities of Natal-RN^a, Barra do Corda-MA^b, São Luís-MA^b, and João Pessoa-PB^c, May, 2015

a) Rio Grande do Norte State
b) Maranhão State
c) Paraíba State

Table 2 - Distribution of exanthematous syndrome cases, according to its appearance in comparison to the other symptoms, part of the body where it began and type, in the municipalities of Natal-RN^a, Barra do Corda-MA^b, São Luís-MA^b, and João Pessoa-PB^c, May, 2015

a) Rio Grande do Norte State
b) Maranhão State
c) Paraíba State
d) The exanthema may have begun in more than one part of the body

Table 3 - Characterization of exanthematous syndrome cases, according to signs and symptoms, in the municipalities of Natal-RN^a, Barra do Corda-MA^b, São Luís-MA^b, and João Pessoa-PB^c, May, 2015

a) Rio Grande do Norte State
b) Maranhão State
c) Paraíba State
d) Auricular, occipital and cervical lymphadenopathy

Table 4 - Distribution of exanthematous syndrome cases, according to part of the body of joint pain, in the municipalities Natal-RN^a, Barra do Corda-MA^b, São Luís-MA^b, and João Pessoa-PB^c, May, 2015

Note: the individual may had pain in more than one joint
a) Rio Grande do Norte State
b) Maranhão State
c) Paraíba State

Table 5 - Distribution of exanthematous syndrome cases, according to platelets and white blood cells count, in the municipalities of Natal-RN^a and João Pessoa-PB^b, May, 2015

Note: the complete blood count was not performed in Barra do Corda-MA and São Luís-MA.
a) Rio Grande do Norte State
b) Paraíba State

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Secretaria de Vigilância em Saúde e Ambiente - Ministério da Saúde do Brasil SRTVN Quadra 701, Via W5 Norte, Lote D, Edifício P0700, CEP: 70719-040, +55 61 3315-3464, Fax: +55 61 3315-3464 - Brasília - DF - Brazil
E-mail: ress.svs@gmail.com

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Description of the first cases of Zika virus fever investigated in municipalities of the Brazilian Northeastern Region, 2015

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[1] All the authors contributed to the study design, development of the questionnaire, collection, analysis and interpretation of data and drafting of the intellectual content of the manuscript.