Trends in mortality from Alzheimer’s disease in Brazil, 2000-2019

Paschalidis, Mayara; Konstantyner, Thais Cláudia Roma de Oliveira; Simon, Sharon Sanz; Martins, Camila Bertini

doi:10.1590/S2237-96222023000200002

Mayara Paschalidis

Contributed to the design, planning, analysis, data interpretation, writing and critical review of the content. All authors approved the final version of the manuscript and are responsible for all aspects of the manuscript, including ensuring its accuracy and integrity.

Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil

http://orcid.org/0000-0001-6661-9955

Thais Cláudia Roma de Oliveira Konstantyner

Contributed to the design, planning, analysis, data interpretation, writing and critical review of the content. All authors approved the final version of the manuscript and are responsible for all aspects of the manuscript, including ensuring its accuracy and integrity.

Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil

http://orcid.org/0000-0002-2289-1866

Sharon Sanz Simon

Contributed to data interpretation and critical review of content. All authors approved the final version of the manuscript and are responsible for all aspects of the manuscript, including ensuring its accuracy and integrity.

Columbia University Medical Center, New York, NY, United States

http://orcid.org/0000-0003-2603-6215

Camila Bertini Martins

Contributed to the design, planning, analysis, data interpretation, writing and critical review of the content. All authors approved the final version of the manuscript and are responsible for all aspects of the manuscript, including ensuring its accuracy and integrity.

Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil

http://orcid.org/0000-0002-8252-8815

Correspondence:
Camila Bertini Martins.
E-mail:
cb.martins@unifesp.br

AUTHOR CONTRIBUTIONS

Paschalidis M, Konstantyner TCRO and Martins CB contributed to the design, planning, analysis, data interpretation, writing and critical review of the content. Simon SS contributed to data interpretation and critical review of content. All authors approved the final version of the manuscript and are responsible for all aspects of the manuscript, including ensuring its accuracy and integrity.

CONFLICTS OF INTEREST

The authors declare they have no conflicts of interest.

Associate editor:

Tais Freire Galvão - https://orcid.org/0000-0003-2072-4834

Macro-region	Age group (years)	Total			Female			Male
Macro-region	Age group (years)	Mean	APC (95%CI)	p-value^a	Mean	APC (95%CI)	p-value^a	Mean	APC (95%CI)	p-value^a
North	60-69	16.5	9.1 (5.2;13.1)	< 0.001	17.2	10.1 (7.2;13.2)	< 0.001	16.6	7.2 (3.8;10.7)	< 0.001
	70-79	155.5	12.4 (10.3;14.6)	< 0.001	164.9	11.9 (10.0;13.8)	< 0.001	145.7	13.5 (11.0;16.0)	< 0.001
	≥ 80	992.8	23.3 (15.7;31.5)	< 0.001	1,134.9	19.9 (15.1;24.9)	< 0.001	818.2	24.7 (14.9;35.2)	< 0.001
Northeast	60-69	23.9	9.6 (7.3;11.9)	< 0.001	22.3	9.7 (7.3;12.3)	< 0.001	25.7	9.8 (7.7;12.0)	< 0.001
	70-79	199.7	12.0 (9.1;15.0)	< 0.001	198.1	12.0 (9.5;14.5)	< 0.001	201.8	12.2 (8.9;15.7)	< 0.001
	≥ 80	1,298.9	18.3 (13.4;23.6)	< 0.001	1,422.1	17.3 (12.2;22.6)	< 0.001	1,116.0	20.4 (15.0;26.2)	< 0.001
Midwest	60-69	37.5	5.0 (3.0;7.0)	< 0.001	36.6	4.7 (1.6;7.9)	0.005	38.6	5.7 (3.5;8.0)	< 0.001
	70-79	351.7	10.1 (6.3;14.0)	< 0.001	352.9	9.6 (6.7;12.7)	< 0.001	350.3	11.0 (6.3;15.9)	< 0.001
	≥ 80	2,380.3	16.2 (10.0;22.8)	< 0.001	2,700.2	14.3 (9.8;19.1)	< 0.001	1,979.1	19.6 (10.5;29.5)	< 0.001
Southeast	60-69	44.6	3.0 (1.6;4.5)	< 0.001	42.0	3.0 (1.7;4.3)	< 0.001	47.7	3.0 (1.6;4.4)	< 0.001
	70-79	412.9	6.8 (3.1;10.6)	0.001	403.6	6.6 (2.9;10.4)	0.001	425.4	7.1 (3.1;11.2)	0.001
	≥ 80	2,929.7	8.5 (5.7;11.5)	< 0.001	3,163.6	8.8 (5.6;12.1)	< 0.001	2,524.8	8.0 (5.0;11.1)	< 0.001
South	60-69	54.4	3.3 (1.8;4.8)	< 0.001	50.7	4.0 (2.1;6.0)	< 0.001	58.6	2.4 (1.2;3.5)	< 0.001
	70-79	473.8	8.1 (4.3;12.0)	< 0.001	462.7	8.4 (4.4;12.6)	< 0.001	488.3	7.2 (4.4;10.1)	< 0.001
	≥ 80	3,145.9	9.0 (6.4;11.6)	< 0.001	3,413.2	9.0 (6.4;11.7)	< 0.001	2,690.6	8.7 (6.6;10.8)	< 0.001
Brazil	60-69	38.9	4.3 (2.9;5.8)	< 0.001	36.8	4.5 (2.8;6.1)	< 0.001	41.4	4.2 (3.0;5.4)	< 0.001
	70-79	350.8	8.1 (4.8;11.5)	< 0.001	346.5	8.0 (4.6;11.6)	< 0.001	356.3	8.2 (4.9;11.6)	< 0.001
	≥ 80	2,368.1	11.3 (8.1;14.6)	< 0.001	2,609.1	11.1 (7.7;14.5)	< 0.001	1,985.4	11.7 (8.5;15.0)	< 0.001

[1] Correspondence:
Camila Bertini Martins.
E-mail:
cb.martins@unifesp.br

Brasil

Brasil

Trends in mortality from Alzheimer’s disease in Brazil, 2000-2019

Tendencias de mortalidad por enfermedad de Alzheimer en Brasil, 2000 a 2019

Abstract

Objective:

Methods:

Results:

Conclusion: