Nanocomposites used in the treatment of skin lesions: a scoping review

Nanocompuestos utilizados en el tratamiento de lesiones cutáneas: una revisión de alcance

ABSTRACT

Objective:

To map the nanocomposites used in the treatment of skin lesions.

Method:

A scoping review, according to the Joanna Briggs Institute methodology, carried out on eight databases, a list of references and Google Scholar to answer the question: “Which nanocomposites are used as a cover for the treatment of skin lesions?”. Two independent reviewers selected the final sample using inclusion/exclusion criteria using the EndNote^® and Rayyan programs. Data was extracted using an adapted form and reported using the PRISMA checklist extension, and the protocol was registered in the Open Science Framework (OSF).

Results:

21 articles were selected, with nanofibers, nanogels and nanomembranes as the nanocomposites described in wound healing, alone or in association with other therapies: negative pressure and elastic. Silver nanomaterials stand out in accelerating healing due to their antimicrobial and anti-inflammatory action, but caution should be exercised due to the risk of cytotoxicity and microbial resistance.

Conclusion:

Nanocomposites used in wound treatment are effective in accelerating healing and reducing costs, and the addition of bioactives to nanomaterials has added extra properties that contribute to healing.

DESCRIPTORS
Wounds and Injuries; Skin Ulcer; Nanocomposites; Nanogels