Conditions associated with adherence to HIV post-sexual exposure prophylaxis

Cross-sectional study conducted in two health care services specializing in HIV/AIDS in São Paulo city. Interviewees included men and women who were eighteen or older, sought care due to consensual sexual relation, and had a recommendation for prophylaxis. The questionnaires which compose the social reproduction index and adherence to prophylaxis were used as parameters. Non-parametric Kruskal-Wallis and Mann-Whitney tests and summation of the employed instrument through programs Excel® and Statistical Package for the Social Sciences® were performed. Ethical principles have been respected.

Results:

Forty-nine users have been identified; their mean age was 34.7 and they were predominantly men (95.9%). Out of these, 83.6% were men who have sex with men. The conditions which correlated with adherence (p<0.05) were taking post-sexual exposure prophylaxis prior to that appointment and continuing to take the medication.

Conclusion:

Health professionals are responsible for establishing rapport with service users, especially during the first appointment, to contribute to adherence interventions plans.

DESCRIPTORS
HIV; Medication Adherence; Post-Exposure Prophylaxis; Public Health Nursing

Variable	Total
Variable	N	%
Sexual relation
Men who have sex only with men	30	61.2
Men who have sex with both men and women	11	22.4
Men who have sex only with women	6	12.3
Women who have sex only with men	2	4.1
Had prior knowledge of PEP
Yes	37	75.5
No	12	24.5
Had used PEP previously
Yes	22	44.9
No	27	55.1

Variable	Adherence score^* * The values of this instrument range from 18 to 90.
Variable	Minimum	Mean (SD)	Maximum	p ^* ***** Tests performed: Wilcoxon-Mann-Whitney (variables: gender, years of education, previous use of PEP, and suspension of medication use) and Kruskal-Wallis (variables: marital status, skin color, religion, social group). The values p<0.05 were statistically significant.
Marital status
Single	49	75.2 (7.8)	88	0.510
Married	76	77.7 (2.8)	82
Divorced	77	77.0^ Standard deviation does not apply (size 1 sample).	77
Domestic partnership	85	85.0^ Standard deviation does not apply (size 1 sample).	85
Skin color
White	49	76.8 (7.8)	88	0.799
Brown	58	74.7 (7.1)	86
Black	61	74.2 (7.9)	84
Asian	76	76.0^ Standard deviation does not apply (size 1 sample).	76
Years of education
4-7	76	78.0 (2.6)	81	0.586
≥8	49	75.5 (7.6)	88	0.586
Religion
Catholic	49	72.4 (10.1)	83	0.544
Evangelical	58	72.2 (9.5)	78
Other	65	76.0 (6.5)	86
None	68	78.0 (5.3)	88
Social group
GI	49	75.6 (7.8)	86	0.464
GII	58	76.5 (7.9)	88
GIII	73	76.6 (2.0)	78
GIV	61	61.0^ Standard deviation does not apply (size 1 sample).	61
Have used PEP previously
Yes	58	73.1 (6.4)	86	0.007
No	49	77.8 (7.6)	88	0.007
Have stopped taking the medication
Yes	46	58.6 (8.4)	69	0.043
No	57	67.0 (3.8)	74

Universidade de São Paulo, Escola de Enfermagem Av. Dr. Enéas de Carvalho Aguiar, 419 , 05403-000 São Paulo - SP/ Brasil, Tel./Fax: (55 11) 3061-7553, - São Paulo - SP - Brazil
E-mail: reeusp@usp.br

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[1] Corresponding author: Marcos Morais Santos Silva, Av. Dr. Enéas de Carvalho Aguiar, 419, Cerqueira César, CEP 05403-000 - São Paulo, SP, Brazil. marcosmoss30@gmail.com