Biological activities: anti-infectious, antioxidant and healing of the vegetable species Jatropha multifida

Vieira, Daniglayse Santos; Oliveira, Fabianny Torres de; Suarez, Jorge Andrés Garcia; Silva, Davi Porfírio da; Bernardo, Thais Honório Lins; Bastos, Maria Lysete de Assis

doi:10.1590/0034-7167-2020-0451

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REVIEW • Rev. Bras. Enferm. 74 (2) • 2021 • https://doi.org/10.1590/0034-7167-2020-0451 copy

Biological activities: anti-infectious, antioxidant and healing of the vegetable species Jatropha multifida

Actividades biológicas: antiinfecciosas, antioxidantes y cicatrizantes de la especie vegetal Jatropha multifida

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Objective:

to investigate the biological activities of interest to the health of Jatropha multifida plant species in published scientific literature.

Methods:

this is an integrative review, with searches between May and June 2019, using the descriptors, combined through the Boolean operator AND, Jatropha multifida, anti-infective agents, wound healing, cytotoxicity and antioxidants, in LILACS, BDENF, MEDLINE, SciFinder, Web of Science and Scopus databases and in the virtual libraries SciELO and ScienceDirect.

Results:

twelve publications were retrieved that showed nine biological activities. The antioxidant activity was reported in 04 (33.33%) studies; antimicrobial and anticancer, addressed by 03 (25%) and 02 (16.66%); anti-inflammatory, anti-melanin deposition, healing, antiophidic, purgative and anti-influenza, seen in 01 (8.33%) each.

Final considerations:

although scarce, the published scientific production highlights the biological potential of J. multifida and supports the need for further studies.

Descriptors:
Medicinal Plants; Anti-Infectives; Wound Healing; Anti-Inflammatories; Antioxidants

Nº	Title	Language/Article origin	Type of study/Level of evidence	Journal/Year/CAPES Qualis
1	Cytotoxic macrocyclic diterpenoids of Jatropha multifida⁽²³23 Zhang Jun-Sheng , Yao Z, Shen L, Abrar A, Gui-Hua T, Sheng Y. Cytotoxic macrocyclic diterpenoids from Jatropha multifida. 2018;80:511-18. https://doi.org/10.1016/j.bioorg.2018.06.025 https://doi.org/10.1016/j.bioorg.2018.06... ⁾	English/China	Experimental/VI	Bioorg Chem 2018/A1
2	The importance of cyclic structure for Labaditin on its antimicrobial activity against Staphylococcus aureus⁽²⁴24 Barbosa SC, Nobre TM, Volpati D, Ciancaglini P, Cilli EM, Lorenzón EM, et al. The importance of cyclic structure for Labaditinon its antimicrobial activity against Staphylococcus aureus. Colloids Surfaces B: Biointerfaces. 2016;148:453-59. https://doi.org/10.2016/j.colsurfb.2016.09.017 https://doi.org/10.2016/j.colsurfb.2016.... ⁾	English/Brazil and Sweden	Experimental/VI	Colloids Surfaces B: Biointerfaces/2016/A1
3	Phytochemical screening, proximate analysis and free radical scavenging activity of the roots extract of Jatropha multifida⁽²⁵25 Ahomafor JE, Erharuyi O, Falodun A Okeri HA. Phytochemical screening, proximate analysis and free radical scavenging activity of the roots extract of jatropha multifida World J Pharmaceutical Res. https://doi.org/10.20959/wjpr201610-6802 https://doi.org/10.20959/wjpr201610-6802... ⁾	English/Nigeria	Experimental/VI	World J pharmaceutical Res/2016/B5
4	Antimicrobial, anti-inflammatory and antioxidant activities of Jatropha multifida L. (Euphorbiaceae)⁽²⁶26 Anani K, Adjrah Y, Améyapoh Y, Karou SD, Agbonon A, de Souza C, Gbeassor M. Antimicrobial, Anti-inflammatory and Antioxidant Activities of Jatropha multifida L. (Euphorbiaceae). Pharmacog Res. 2016;8(2):142-46. https://doi.org/10.4103/0974-8490.172657 https://doi.org/10.4103/0974-8490.172657... ⁾	English/Togo	Experimental/VI	Pharmacog Res./2016/B4
5	Diterpenoids with thioredoxin reductase inhibitory activities from Jatropha multifida⁽²⁷27 Jian-Yong Zhu, Chun-Yang Zhang, Jing-Jing Dai, Khalid Rahman, Hong Zhang. Diterpenoids with thioredoxin reductase inhibitory activities from Jatropha multifida. J Nat Prod Res. 2017;31(23):2753-58. https://doi.org/10.1080/14786419.2017.1297441 https://doi.org/10.1080/14786419.2017.12... ⁾	English/China/UK	Experimental/VI	Nat. Prod. Res/2017/B1
6	Anti-melanin deposition activity and active constituents of Jatropha multifida stems⁽²⁸28 Woo SY, Wong CP, Win NN, Lae KZW, Woo W, Elsabbagh AS, et al. Anti-melanin deposition activity and active constituents of Jatropha multifida stems. J Nat Med. 2019;73:805-13. https://doi.org/10.1007/s11418-019-01314-7 https://doi.org/10.1007/s11418-019-01314... ⁾	English/Japan	Experimental/VI	J Nat Med./2019/A1
7	Modification of polyethylene oxide-polyethylene glycol dimethacrylate hydrogel film by the addition of Jatropha multifida sap for wound dressing application⁽²⁹29 Haryanto F, Hardiningrum D, Swantomo D. Modification of polyethylene oxide-polyethyleneglycol dimethacrylate hydrogel film by the addition of Jatropha multifida sap for wound dressing application. AIP Conference Proceedings 2019;2085(1):020061. https://doi.org/10.1063/1.5095039 https://doi.org/10.1063/1.5095039... ⁾	English/Indonesia	Experimental/VI	AIP conference proceedings/2019/B2
8	Total flavonoid content and formulation of antioxidant cream stem from jatropha multifida⁽³⁰30 Franyoto YD, Kusmita L, Mutmainah, Agrena RD. Total flavonoid content and formulation antioxidant cream stem of jatropha multifida L. IOP Conf. Series: J Phys Conf Series. 2018;012130. https://doi.org/10.1088/1742-6596/1025/1/012130 https://doi.org/10.1088/1742-6596/1025/1... ⁾	English/Indonesia	Experimental/VI	J Physics: conference series/2018/B1
9	Antimicrobial, antioxidant and cytotoxicity potential of Manihot multifida (L.) Crantz (Euphorbiaceae)⁽³¹31 Fabri LR, Sá DS, Perreira APO, Scio E, Pimenta DS, Chedier LM. Antimicrobial, antioxidant and cytotoxicity potential of Manihot multifida (L.) Crantz (Euphorbiaceae). An Acad Bras Ciênc. 2015;87(1):303-11. https://doi.org/10.1590/0001-3765201520130251 https://doi.org/10.1590/0001-37652015201... ⁾	English/Brazil	Experimental/VI	An. Acad. Bras. Ciênc.,/2015/B1
10	Ethnopharmacological survey on medicinal plants used in snakebite treatments in Western and Sabaragamuwa provinces in Sri Lanka⁽³²32 Dharmadasa RM, Akalanka GC, Muthukumarana PRM, Wijesekara RGS. Ethnopharmacological survey on medicinal plants used in snakebite treatments in Western and Sabara gamuwa provinces in Sri Lanka. J Ethnopharmacol. 2015;179:110-27. https://doi.org/10.1016/j.jep.2015.12.041 https://doi.org/10.1016/j.jep.2015.12.04... ⁾	English/Sri Lanka	Etnobotânico/IV	J. Ethnopharmacol/2015/A2
11	A comprehensive review of ethnopharmacologically important medicinal plant species from Mauritius⁽³³33 Suroowana S, Pynee KB, Mahomoodally MF. A comprehensive review of ethnopharmacologically important medicinal plant species from Mauritius. South African J Bot. 2019;122:189-13. https://doi.org/10.1016/j.sajb.2019.03.024 https://doi.org/10.1016/j.sajb.2019.03.0... ⁾	English/Mauritius island	Etnobotânico/IV	South African Journal of Botany/2019/B1
12	Anti-influenza virus activity of extracts from the stem of Jatropha multifida Linn. Collected in Myanmar⁽³⁴34 Shoji M, Woo S, Masuda A, Win NN, Ngwe H, Takahashi E, et al. Anti-influenza vírus activity of extracts from the stems of Jatropha multifida Linn. collected in Myanmar. BMC Complement Altern Med. 2017;96. https://doi.org/10.1186/s12906-017-1612-8 https://doi.org/10.1186/s12906-017-1612-... ⁾	English/Japan	Experimental/VI	Complement Altern Med./2017/B2

Nº	Objective	Biological activity	Main results
1	Identifying the structures of nine new macrocyclic diterpenoids (1-9), Jatromultones AI, along with eight known analogs (10-17) that were isolated from the Jatropha multifidatrunks	Anticancer	New compounds have been elucidated and screened for cytotoxicity against five cancer cell lines, including a drug-resistant cell line. Of these, seven compounds exhibited significant activity. The study provided a new natural compound for the development of anticancer drug.
2	To investigate the mechanism of action at the molecular level for Labaditin (Lo), a 10 amino acid cyclic peptide from Jatropha multifida with known bactericidal activity against Streptococcus mutans.	Bactericide	Lo has been shown to be effective against Staphylococcus aureus. Moreover, it does not require specific metabolic targets, which makes cyclic peptides promising for antibiotics without bacterial resistance.
3	Assessing phytochemical screening, centesimal analysis and scavenging activity of free radicals of ethyl acetate, petroleum ether, chloroform, as well as the crude root extract of Jatropha multifida.	Anti-oxidant	Screening revealed the presence of carbohydrates, reducing sugars, phenolics, flavonoids, glycosides, saponins and steroids. The antioxidant property was more evident in chloroform extracts compared to other fractions.
4	Investigating the antibacterial, anti-inflammatory and antioxidant activities of the ethanolic extract of J. multifida leaves.	Antioxidant anti-inflammatory bactericide	The antibacterial assay showed growth in vitro inhibition of P. aeruginosa and S. aureus in a dose-dependent manner. The anti-inflammatory effect occurred after 3 and 5 h after administration of histamine and carrageenan, respectively. DPPH and FRAP tests showed weak antioxidant activity.
5	Determining the thioredoxin (TrxR) inhibitory activity of Jatropha, which is a potential target for cancer chemotherapy with redox balance and antioxidant functions.	Anticancer	The chemical investigation of J. multifida led to isolation of nine diterpenes (1-9). The results showed that two compounds (6 and 7) had stronger inhibitory activities. Compounds (5 and 9) exhibited moderate activity, while others were inactive.
6	Assessing the anti-melanin deposition activity of J. multifida and to elucidate the mechanisms of action of the isolated compounds.	Anti-melanin deposition	The chloroform stem extract showed anti-melanin deposition activity against induced melanogenesis. Fractionation and purification of the main constituents led to the isolation of two coumarins (1 and 2) and seven known lignoids (3-9). All isolates exhibited anti-melanin deposition activities against the mouse melanoma strain (B16-F10).
7	Adding the J. multifida sap to the hydrogel before crosslinking using electron beam.	Healing	The PEO-PEGDMA crosslinked hydrogel film can be developed with the addition of J. multifida sap with greater tensile strength using electron beam irradiation.
8	Detecting the total flavonoid content and antioxidant activity of the cream formulated from the J. multifida stems.	Anti-oxidant	The results showed that the extracts of J. multifida can be considered as a natural antioxidant and can be useful to heal diseases resulting from oxidative deterioration. A cream was formulated comprising 5% of extract using the fusion method, presenting good results and suggesting potential for the development of cosmetics.
9	Assessing the in vitro antioxidant potential and antimicrobial potential of this species against strains of Gram-positive and Gram-negative bacteria and fungi, known for infections in humans.	Antimicrobial and antioxidant	The antimicrobial activity was evidenced in the extracts (aqueous and hexanic/leaves; methanolic/fruits) with minimum inhibitory concentration (MIC) of 39 to 2,500 µg/mL. The best activity was against C. albicans (ATCC 18804) with MIC of 39 µg/mL. The cytotoxic activity with Artemiasaline was stronger for the methanolic extract of the leaves (CL₅₀ of 15.6 µg/mL).
10	Surveying the types of medicinal plant materials, including the specific plant parts that are available for snakebite treatment.	Antiophidic	341 species of plants belonging to 99 families have been documented. The largest number of plants reported was from Fabaceae family (32 species). A J. multifida has been cited for the treatment of poisonous snake bites in the form of bandages.
11	Highlighting species of medicinal plants that deserve due attention regarding the assessment of their pharmacological potential.	Purgative	J. multifida popularly known as coral tree, has traditionally been reported with purgative use.
12	Assessing the anti-influenza activity of extracts from the stems of Jatropha multifida Linn	Anti-influenza	Aqueous and chlorophoric extract from the stems of J. multifida collected in Myanmar demonstrated stronger inhibition of viral infection for H1N1 influenza.

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[1] Corresponding author: Maria Lysete de Assis Bastos. E-mail: lysetebastos@gmail.com