Glycemic variability and mortality in oncologic intensive care units

Variabilidade glicêmica e mortalidade em unidades de terapia intensiva oncológicas

Variabilidad glucémica y mortalidad en unidades de cuidados intensivos oncológicos

ABSTRACT

Objective:

This study aimed to investigate the association between glycemic variability and mortality in patients admitted to oncologic intensive care units.

Methods:

A retrospective cohort study was conducted using a convenience sample of 30 medical records of patients over 18 years of age of both sexes. Glycemic variability was measured using the standard deviation and general amplitude. Statistical analysis was performed using the receiver operating characteristic (ROC) curve and the area under the curve (AUC). The significance level (α) was set at 5% with a confidence interval (CI) of 95%.

Results:

The study included 14 male patients (46.67%) with a mean age of 60±15 years. A total of 1503 blood glucose samples were collected. The AUC analysis for the standard deviation did not show a statistically significant result (p=.966; 95% CI=[0.283, 0.726]). In contrast, the general amplitude had a statistically significant association with mortality (p=.049; 95% CI=[0.514, 0.916]).

Conclusions:

This study found that glycemic variability measured by the general amplitude was significantly associated with patient mortality in oncologic intensive care units. These findings suggest that monitoring glycemic variability may be an important factor in the management of critically ill patients in oncologic intensive care units.

Descriptors:
Intensive Care Units; Blood Glucose; Mortality; Neoplasms; Glycemic Control.